| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| William Contreras | C | Atl | 23 | |
| Eric Haase | C (OF,DH) | Det | 28 | |
| Dom Nunez | C | Col | 26 | |
| Matt Olson | 1B (DH) | Oak | 27 | |
| Miguel Sano | 1B (3B,DH) | Min | 28 | |
| Dom Smith | 1B (OF) | NYN | 26 | |
| Andrew Vaughn | 1B (OF,DH) | ChA | 23 | |
| Javier Baez | SS (2B) | NYN | 28 | |
| Jeter Downs | SS | Bos | 23 | |
| Luis Urias | SS (2B,3B) | Mil | 24 | |
| Miguel Andújar | 3B (OF) | NYA | 26 | July 07, 2021:10 Day IL-Strained left wrist |
| Nick Solak | 3B (2B,DH) | Tex | 26 | |
| Abraham Toro | 3B (2B) | Sea | 24 | |
| Andrew Benintendi | OF | KC | 27 | |
| Jasson Dominguez | OF | NYA | 18 | |
| Kyle Lewis | OF | Sea | 26 | June 01, 2021:10 Day IL-Meniscus tear in right knee |
| Rafael Ortega | OF | ChN | 30 | |
| Franmil Reyes | OF (DH) | Cle | 26 | |
| LaMonte Wade Jr | OF (1B) | SF | 27 | |
| Adbert Alzolay | SP (RP) | ChN | 26 | |
| Jake Arrieta | SP | SD | 35 | |
| Aaron Civale | SP | Cle | 26 | |
| Mike Clevinger | SP | SD | 30 | February 18, 2021:60 Day IL-Recovery from right elbow surgery |
| Michael Fiers | SP | Oak | 36 | May 07, 2021:10 Day IL-Right elbow sprain |
| Jack Flaherty | SP | StL | 25 | |
| Triston McKenzie | SP | Cle | 24 | |
| Wily Peralta | SP | Det | 32 | |
| Tarik Skubal | SP (RP) | Det | 24 | |
| Spencer Turnbull | SP | Det | 29 | June 05, 2021:10 Day IL-Strained right forearm |
| Justin Verlander | SP | Hou | 38 | February 27, 2021:60 Day IL-Recovery from right elbow surgery |
| Jake Woodford | SP (RP) | StL | 24 | |
| Amir Garrett | RP | Cin | 29 | |
| James Karinchak | RP | Cle | 26 | |
| Richard RodrÃguez | RP | Atl | 31 |