| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Tucker Barnhart | C | Cin | 30 | |
| Willson Contreras | C | ChN | 29 | |
| Carlos Santana | 1B (DH) | KC | 35 | |
| Spencer Torkelson | 1B | Det | 22 | |
| Luis Arraez | 2B (3B,OF,DH) | Min | 24 | |
| Gavin Lux | 2B (SS,OF) | LAD | 23 | |
| Jurickson Profar | 2B (1B,OF) | SD | 28 | |
| Willi Castro | SS (2B,OF,DH) | Det | 24 | |
| Carlos Correa | SS | Hou | 27 | |
| Ke'Bryan Hayes | 3B | Pit | 24 | |
| Evan Longoria | 3B | SF | 35 | |
| Austin Riley | 3B (1B) | Atl | 24 | |
| Eugenio Suarez | 3B (SS) | Cin | 30 | |
| Jo Adell | OF | LAA | 22 | September 12, 2021:10 Day IL-Left abdominal strain |
| Lorenzo Cain | OF | Mil | 35 | |
| Kole Calhoun | OF (DH) | Ari | 33 | |
| Michael Conforto | OF | NYN | 28 | |
| Jasson Dominguez | OF | NYA | 18 | |
| Austin Hays | OF | Bal | 26 | |
| Bryan Reynolds | OF | Pit | 26 | |
| Myles Straw | OF | Cle | 26 | |
| Nelson Cruz | DH | TB | 41 | |
| Josh Fleming | SP (RP) | TB | 26 | |
| Zack Greinke | SP | Hou | 37 | September 21, 2021:10 Day IL-Neck soreness |
| Vladimir Gutierrez | SP | Cin | 26 | |
| Elieser Hernandez | SP | Mia | 26 | |
| Clayton Kershaw | SP | LAD | 33 | |
| Triston McKenzie | SP | Cle | 24 | |
| Wade Miley | SP | Cin | 34 | September 22, 2021:10 Day IL-Neck strain |
| Frankie Montas | SP | Oak | 28 | |
| Mike Soroka | SP | Atl | 24 | March 31, 2021:15 Day IL-Achilles |
| Jake Woodford | SP (RP) | StL | 24 | |
| Aroldis Chapman | RP | NYA | 33 | |
| Raisel Iglesias | RP | LAA | 31 |