| Name | Pos | Team | Age | Injured List |
|---|---|---|---|---|
| Mitch Garver | C (1B,DH) | Min | 30 | |
| Seth Beer | 1B (DH) | Ari | 25 | September 17, 2021:10 Day IL-Dislocated left shoulder |
| Bobby Bradley | 1B (DH) | Cle | 25 | |
| Triston Casas | 1B | Bos | 21 | |
| Carlos Santana | 1B (DH) | KC | 35 | |
| Ty France | 2B (1B,3B,DH) | Sea | 27 | |
| Brandon Lowe | 2B (OF,DH) | TB | 27 | |
| Adalberto Mondesà | SS (3B,DH) | KC | 26 | |
| Alec Bohm | 3B (1B) | Phi | 25 | |
| Matt Chapman | 3B (SS) | Oak | 28 | |
| Nolan Jones | 3B | Cle | 23 | |
| Riley Greene | OF | Det | 20 | |
| Josh Lowe | OF | TB | 23 | |
| Austin Martin | OF | Min | 22 | |
| Andrew McCutchen | OF | Phi | 34 | |
| Brandon Nimmo | OF | NYN | 28 | |
| Tyler O'Neill | OF | StL | 26 | |
| Franmil Reyes | OF (DH) | Cle | 26 | |
| Luis Robert | OF | ChA | 24 | |
| Julio Rodriguez | OF | Sea | 20 | |
| J.D. Martinez | DH (OF) | Bos | 34 | |
| Alexander Cobb | SP | LAA | 33 | |
| Pat Corbin | SP | Was | 32 | |
| Josh Fleming | SP (RP) | TB | 26 | |
| Zac Gallen | SP | Ari | 26 | |
| Hunter Greene | SP | Cin | 22 | |
| Tanner Houck | SP (RP) | Bos | 25 | |
| Kwang-Hyun Kim | SP (RP) | StL | 33 | |
| Daniel Lynch | SP | KC | 24 | |
| Michael Pineda | SP | Min | 32 | |
| Chris Sale | SP | Bos | 32 | |
| Logan Webb | SP | SF | 24 | |
| Liam Hendriks | RP | ChA | 32 | |
| Kenley Jansen | RP | LAD | 33 |