| Round | Overall | Player |
|---|---|---|
| 1 | 12th | OF Ronald Acuna Jr. Atl |
| 2 | 13th | 1B Matt Olson Atl |
| 3 | 36th | SP Brandon Woodruff Mil |
| 4 | 37th | SP Sandy Alcántra Mia |
| 5 | 60th | OF Tyler O'Neill StL |
| 6 | 61st | SP Freddy Peralta Mil |
| 7 | 84th | 3B Anthony Rendon LAA |
| 8 | 85th | 1B Spencer Torkelson Det |
| 9 | 108th | C Yasmani Grandal ChA |
| 10 | 109th | 3B Yoan Moncada ChA |
| 11 | 132nd | SP Trevor Rogers Mia |
| 12 | 133rd | SS Oneil Cruz Pit |
| 13 | 156th | SS Willy Adames Mil |
| 14 | 157th | SP Logan Gilbert Sea |
| 15 | 180th | 2B Gavin Lux LAD |
| 16 | 181st | SP Triston McKenzie Cle |
| 17 | 204th | 2B Keston Hiura Mil |
| 18 | 205th | RP Matt Barnes Bos |
| 19 | 228th | C Adley Rutschman Bal |
| 20 | 229th | OF Andrew Vaughn ChA |
| 21 | 252nd | SP Cal Quantrill Cle |
| 22 | 253rd | 1B Bobby Bradley Cle |
| 23 | 276th | RP Andrew Kittredge TB |
| 24 | 277th | 1B Brandon Belt SF |
| 25 | 300th | OF Aaron Hicks NYA |
| 26 | 301st | SP Tylor Megill NYN |
| 27 | 324th | C Joey Bart SF |
| 28 | 325th | RP David Bednar Pit |
| 29 | 348th | OF Jake Fraley Cin |