| Round | Overall | Player |
|---|---|---|
| 1 | 10th | 3B Rafael Devers Bos |
| 2 | 15th | SS Trea Turner Phi |
| 3 | 34th | OF George Springer Tor |
| 4 | 39th | OF Nick Castellanos Cin |
| 5 | 58th | SP Lucas Giolito ChA |
| 6 | 63rd | OF Tyler O'Neill StL |
| 7 | 82nd | OF Kyle Schwarber Phi |
| 8 | 87th | SP Robbie Ray Sea |
| 9 | 106th | 2B Jonathan India Cin |
| 10 | 111th | SP Framber Valdez Hou |
| 11 | 130th | 3B Ryan Mountcastle Bal |
| 12 | 135th | SP Yu Darvish SD |
| 13 | 154th | SS Willy Adames Mil |
| 14 | 159th | SP Ranger Suarez Phi |
| 15 | 178th | SP Tyler Mahle Min |
| 16 | 183rd | 2B D.J. LeMahieu NYA |
| 17 | 202nd | 1B Trey Mancini Hou |
| 18 | 207th | 1B Nate Lowe Tex |
| 19 | 226th | SP Cal Quantrill Cle |
| 20 | 231st | SP Jonathan Gray Tex |
| 21 | 250th | 2B Mike Moustakas Cin |
| 22 | 255th | SP Josiah Gray Was |
| 23 | 274th | SP Yusei Kikuchi Tor |
| 24 | 279th | OF Andrew McCutchen Mil |
| 25 | 298th | SP Kyle Freeland Col |
| 26 | 303rd | C Omar Narváez Mil |
| 27 | 322nd | SP Jack Leiter Tex |
| 28 | 327th | C Elias Diaz Col |
| 29 | 346th | OF Gavin Sheets ChA |