*=Defensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 20.00 | Week 05, 2014 | Buf | @Det@Det | 5 Tackles, 3.0 Sacks, 1 FF |
| 2. | 19.00 | Week 10, 2014 | Buf | KCKC | 4 Tackles, 3 Assists, 3.0 Sacks |
| 3. | 16.00 | Week 12, 2016 | Buf | JacJac | 5 Tackles, 3 Assists, 2.0 Sacks |
| 4. | 15.00 | Week 04, 2013 | Buf | BalBal | 5 Tackles, 2 Assists, 2.0 Sacks |
| 5. | 14.00 | Week 08, 2011 | Buf | WasWas | 2 Tackles, 2 Assists, 2.5 Sacks |
| 6. | 13.00 | Week 13, 2013 | Buf | AtlAtl | 4 Tackles, 4 Assists, 1.0 Sack, 1 PD |
| 7. | 12.00 | Week 08, 2018 | Jac | PhiPhi | 3 Tackles, 2 Assists, 1.0 Sack, 1 FF |
| 7. | 12.00 | Week 07, 2014 | Buf | MinMin | 3 Tackles, 1 Assist, 2.0 Sacks |
| 7. | 12.00 | Week 16, 2012 | Buf | @Mia@Mia | 4 Tackles, 2.0 Sacks |
| 10. | 11.00 | Week 10, 2013 | Buf | @Pit@Pit | 3 Tackles, 1 Assist, 1.0 Sack, 1 FF |
| 11. | 9.00 | Week 12, 2012 | Buf | @Ind@Ind | 5 Tackles, 1.0 Sack |
| 11. | 9.00 | Week 10, 2012 | Buf | @NE@NE | 4 Tackles, 1 Assist, 0.5 Sack, 2 PD |
| 11. | 9.00 | Week 14, 2011 | Buf | @SD@SD | 3 Tackles, 2 Assists, 1.0 Sack |
| 14. | 8.00 | Week 17, 2017 | Jac | @Ten@Ten | 4 Tackles, 1.0 Sack |
| 14. | 8.00 | Week 08, 2016 | Buf | NENE | 4 Tackles, 1.0 Sack |
| 14. | 8.00 | Week 03, 2015 | Buf | @Mia@Mia | 4 Tackles, 1.0 Sack |
| 14. | 8.00 | Week 04, 2014 | Buf | @Hou@Hou | 4 Tackles, 1.0 Sack |
| 14. | 8.00 | Week 06, 2013 | Buf | CinCin | 4 Tackles, 1.0 Sack |
| 14. | 8.00 | Week 09, 2011 | Buf | NYJNYJ | 4 Tackles, 1 Assist, 1 Fum Rcvy |
| 14. | 8.00 | Week 04, 2011 | Buf | @Cin@Cin | 2 Tackles, 2 Assists, 1.0 Sack |
| 21. | 7.00 | Week 16, 2016 | Buf | MiaMia | 4 Tackles, 3 Assists |
| 21. | 7.00 | Week 14, 2016 | Buf | PitPit | 5 Tackles, 2 Assists |
| 21. | 7.00 | Week 11, 2016 | Buf | @Cin@Cin | 2 Tackles, 2 Assists, 0.5 Sack, 1 PD |
| 21. | 7.00 | Week 10, 2015 | Buf | @NYJ@NYJ | 2 Tackles, 1 Assist, 1.0 Sack |
| 21. | 7.00 | Week 15, 2013 | Buf | @Jac@Jac | 3 Tackles, 1.0 Sack |
| 21. | 7.00 | Week 14, 2013 | Buf | @TB@TB | 2 Tackles, 1 Assist, 1.0 Sack |
| 21. | 7.00 | Week 01, 2013 | Buf | NENE | 4 Tackles, 2 Assists, 1 PD |
| 21. | 7.00 | Week 15, 2011 | Buf | MiaMia | 3 Tackles, 1.0 Sack |
| 29. | 6.00 | Week 03, 2018 | Jac | TenTen | 4 Tackles, 2 Assists |
| 29. | 6.00 | Week 05, 2017 | Buf | @Cin@Cin | 1 Tackle, 1 Assist, 1.0 Sack |
| 29. | 6.00 | Week 12, 2015 | Buf | @KC@KC | 6 Tackles |
| 29. | 6.00 | Week 07, 2013 | Buf | @Mia@Mia | 4 Tackles, 2 Assists |
| 29. | 6.00 | Week 02, 2013 | Buf | CarCar | 4 Assists, 0.5 Sack |
| 29. | 6.00 | Week 04, 2012 | Buf | NENE | 3 Assists, 0.5 Sack, 1 PD |
| 29. | 6.00 | Week 02, 2012 | Buf | KCKC | 2 Tackles, 1.0 Sack |
| 36. | 5.00 | Week 03, 2019 | Jac | TenTen | 1 Tackle, 2 Assists, 0.5 Sack |
| 36. | 5.00 | Week 01, 2018 | Jac | @NYG@NYG | 3 Tackles, 2 Assists |
| 36. | 5.00 | Week 07, 2017 | Buf | TBTB | 3 Tackles, 2 Assists |
| 36. | 5.00 | Week 14, 2015 | Buf | @Phi@Phi | 3 Tackles, 2 Assists |
| 36. | 5.00 | Week 05, 2015 | Buf | @Ten@Ten | 2 Tackles, 3 Assists |
| 36. | 5.00 | Week 03, 2014 | Buf | SDSD | 3 Tackles, 2 Assists |
| 36. | 5.00 | Week 09, 2013 | Buf | KCKC | 4 Tackles, 1 Assist |
| 36. | 5.00 | Week 05, 2013 | Buf | @Cle@Cle | 1 Tackle, 4 Assists |
| 36. | 5.00 | Week 11, 2012 | Buf | MiaMia | 2 Tackles, 2 Assists, 1 PD |
| 36. | 5.00 | Week 05, 2012 | Buf | @SF@SF | 2 Tackles, 1 Fum Rcvy |
| 46. | 4.00 | Week 05, 2019 | Jac | @Car@Car | 2 Tackles, 2 Assists |
| 46. | 4.00 | Week 10, 2017 | Jac | LACLAC | 3 Tackles, 1 Assist |
| 46. | 4.00 | Week 17, 2016 | Buf | @NYJ@NYJ | 2 Tackles, 2 Assists |
| 46. | 4.00 | Week 13, 2016 | Buf | @Oak@Oak | 2 Tackles, 2 Assists |
| 46. | 4.00 | Week 13, 2015 | Buf | HouHou | 3 Tackles, 1 Assist |