*=Defensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 21.00 | Week 08, 2004 | SF | @Chi@Chi | 10 Tackles, 2.0 Sacks, 1 Fum Rcvy |
| 2. | 18.00 | Week 10, 2000 | SF | @NO@NO | 6 Tackles, 4 Assists, 2.0 Sacks |
| 3. | 17.00 | Week 02, 2007 | SF | @StL@StL | 6 Tackles, 2.0 Sacks, 1 FF |
| 3. | 17.00 | Week 04, 2005 | SF | @Ari@Ari | 5 Tackles, 1 Assist, 2.0 Sacks, 1 FF |
| 5. | 16.00 | Week 01, 2005 | SF | StLStL | 4 Tackles, 3.0 Sacks |
| 5. | 16.00 | Week 15, 2000 | SF | NONO | 4 Tackles, 2 Assists, 2.5 Sacks |
| 7. | 15.00 | Week 11, 2007 | SF | StLStL | 3 Tackles, 1 Assist, 2.5 Sacks, 1 PD |
| 7. | 15.00 | Week 14, 1999 | SF | AtlAtl | 2 Tackles, 1 Assist, 2.5 Sacks, 1 Safety |
| 9. | 14.00 | Week 08, 2005 | SF | TBTB | 3 Tackles, 2.0 Sacks, 1 FF |
| 10. | 12.00 | Week 10, 1999 | SF | @NO@NO | 4 Tackles, 2.0 Sacks |
| 10. | 12.00 | Week 12, 1998 | SF | NONO | 2 Tackles, 2 Assists, 2.0 Sacks |
| 10. | 12.00 | Week 08, 1998 | SF | @StL@StL | 8 Tackles, 1.0 Sack |
| 10. | 12.00 | Week 06, 1998 | SF | @NO@NO | 4 Tackles, 2 Assists, 1.5 Sacks |
| 10. | 12.00 | Week 02, 1998 | SF | @Was@Was | 4 Tackles, 2.0 Sacks |
| 15. | 11.00 | Week 03, 2005 | SF | DalDal | 5 Tackles, 1 Assist, 1.0 Sack, 1 PD |
| 15. | 11.00 | Week 11, 2000 | SF | KCKC | 3 Tackles, 2.0 Sacks |
| 15. | 11.00 | Week 16, 1999 | SF | WasWas | 2 Tackles, 1 Assist, 2.0 Sacks |
| 18. | 10.00 | Week 12, 2006 | SF | @StL@StL | 3 Tackles, 1 Assist, 1.5 Sacks |
| 18. | 10.00 | Week 16, 2003 | SF | @Phi@Phi | 2 Tackles, 2 Assists, 1.5 Sacks |
| 18. | 10.00 | Week 09, 2003 | SF | StLStL | 3 Tackles, 1.0 Sack, 1 FF |
| 18. | 10.00 | Week 01, 2001 | SF | AtlAtl | 2 Tackles, 2.0 Sacks |
| 18. | 10.00 | Week 12, 2000 | SF | AtlAtl | 2 Tackles, 2.0 Sacks |
| 18. | 10.00 | Week 13, 1999 | SF | @Cin@Cin | 2 Tackles, 2.0 Sacks |
| 18. | 10.00 | Week 11, 1998 | SF | @Atl@Atl | 4 Tackles, 2 Assists, 1.0 Sack |
| 18. | 10.00 | Week 08, 1997 | SF | AtlAtl | 5 Tackles, 1 Assist, 1.0 Sack |
| 26. | 9.00 | Week 01, 2007 | SF | AriAri | 5 Tackles, 1.0 Sack |
| 26. | 9.00 | Week 02, 2006 | SF | StLStL | 5 Tackles, 1.0 Sack |
| 26. | 9.00 | Week 13, 2004 | SF | @StL@StL | 4 Tackles, 1.0 Sack, 1 PD |
| 26. | 9.00 | Week 11, 1999 | SF | StLStL | 4 Tackles, 1 Assist, 1.0 Sack |
| 26. | 9.00 | Week 05, 1998 | SF | @Buf@Buf | 5 Tackles, 1.0 Sack |
| 26. | 9.00 | Week 04, 1998 | SF | AtlAtl | 3 Tackles, 2 Assists, 1.0 Sack |
| 26. | 9.00 | Week 12, 1997 | SF | @Car@Car | 4 Tackles, 1 Assist, 1.0 Sack |
| 33. | 8.00 | Week 01, 2006 | SF | @Ari@Ari | 3 Tackles, 1 Assist, 1.0 Sack |
| 33. | 8.00 | Week 14, 2003 | SF | AriAri | 4 Tackles, 1 Assist, 0.5 Sack, 1 PD |
| 33. | 8.00 | Week 14, 2001 | SF | MiaMia | 5 Tackles, 1 Assist, 0.5 Sack |
| 33. | 8.00 | Week 04, 1997 | SF | @Atl@Atl | 3 Tackles, 1 Assist, 1.0 Sack |
| 37. | 7.00 | Week 02, 2004 | SF | @NO@NO | 3 Tackles, 1 Assist, 1 FF |
| 37. | 7.00 | Week 08, 2003 | SF | @Ari@Ari | 3 Tackles, 1.0 Sack |
| 37. | 7.00 | Week 07, 2000 | SF | @GB@GB | 3 Tackles, 1.0 Sack |
| 37. | 7.00 | Week 07, 1999 | SF | @Min@Min | 3 Tackles, 1.0 Sack |
| 37. | 7.00 | Week 07, 1997 | SF | @StL@StL | 1 Tackle, 2 Assists, 1.0 Sack |
| 42. | 6.00 | Week 09, 2006 | SF | MinMin | 1 Assist, 0.5 Sack, 1 FF |
| 42. | 6.00 | Week 05, 2006 | SF | OakOak | 1 Tackle, 1 Assist, 1.0 Sack |
| 42. | 6.00 | Week 15, 2004 | SF | WasWas | 5 Tackles, 1 Assist |
| 42. | 6.00 | Week 12, 2002 | SF | PhiPhi | 2 Tackles, 2 Assists, 0.5 Sack |
| 42. | 6.00 | Week 08, 2002 | SF | AriAri | 2 Tackles, 1.0 Sack |
| 42. | 6.00 | Week 16, 2001 | SF | @Dal@Dal | 2 Tackles, 1.0 Sack |
| 48. | 5.00 | Week 14, 2006 | SF | GBGB | 4 Tackles, 1 PD |
| 48. | 5.00 | Week 11, 2006 | SF | SeaSea | 3 Tackles, 2 Assists |
| 48. | 5.00 | Week 10, 2004 | SF | CarCar | 2 Tackles, 1 Assist, 0.5 Sack |