*=Offensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 49.00 | Week 14, 2003 | SF | AriAri | 252 Pass, 32 Rush, 6 TD |
| 2. | 43.00 | Week 05, 2001 * | SF | @Atl@Atl | 332 Pass, 70 Rush, 4 TD, 1 Fumb |
| 3. | 40.00 | Week 14, 2002 * | SF | @Dal@Dal | 276 Pass, 50 Rush, 4 TD |
| 4. | 38.00 | Week 06, 2000 * | SF | OakOak | 336 Pass, 16 Rush, 4 TD |
| 5. | 37.00 | Week 07, 2000 | SF | @GB@GB | 336 Pass, 6 Rush, 4 TD |
| 6. | 36.00 | Week 15, 2000 | SF | NONO | 305 Pass, 42 Rush, 4 TD, 2 Int |
| 7. | 35.00 | Week 15, 2003 | SF | @Cin@Cin | 344 Pass, 51 Rush, 3 TD, 1 Fumb |
| 7. | 35.00 | Week 08, 2002 * | SF | AriAri | 252 Pass, 14 Rush, 4 TD |
| 7. | 35.00 | Week 04, 2000 | SF | @Dal@Dal | 178 Pass, 43 Rush, 4 TD |
| 7. | 35.00 | Week 17, 1999 | SF | @Atl@Atl | 373 Pass, 26 Rush, 3 TD, 1 2-Pt, 1 Fumb |
| 11. | 34.00 | Week 09, 2001 | SF | NONO | 252 Pass, -6 Rush, 4 TD |
| 11. | 34.00 | Week 13, 1999 | SF | @Cin@Cin | 437 Pass, 12 Rush, 3 TD, 1 Int |
| 13. | 33.00 | Week 17, 2001 | SF | @NO@NO | 263 Pass, 3 Rush, 4 TD, 1 Fumb |
| 14. | 31.00 | Week 13, 2006 | Phi | CarCar | 312 Pass, 12 Rush, 3 TD |
| 14. | 31.00 | Week 06, 2004 | Cle | CinCin | 310 Pass, 1 Rush, 4 TD, 2 Int, 1 Fumb |
| 16. | 29.00 | Week 16, 2000 | SF | ChiChi | 402 Pass, 16 Rush, 2 TD |
| 17. | 28.00 | Week 01, 2003 | SF | ChiChi | 229 Pass, 36 Rush, 3 TD, 1 Int |
| 17. | 28.00 | Week 10, 2001 | SF | @Car@Car | 305 Pass, 1 Rush, 3 TD, 2 Int, 1 2-Pt |
| 17. | 28.00 | Week 01, 2000 | SF | @Atl@Atl | 253 Pass, 22 Rush, 3 TD, 1 Int |
| 20. | 27.00 | Week 09, 2002 | SF | @Oak@Oak | 282 Pass, 46 Rush, 2 TD |
| 20. | 27.00 | Week 16, 2001 | SF | @Dal@Dal | 229 Pass, 6 Rush, 3 TD |
| 20. | 27.00 | Week 14, 2000 | SF | @SD@SD | 323 Pass, 19 Rush, 2 TD, 1 2-Pt |
| 20. | 27.00 | Week 04, 1999 | SF | TenTen | 243 Pass, 8 Rush, 3 TD |
| 24. | 26.00 | Week 05, 2003 | SF | DetDet | 192 Pass, 35 Rush, 3 TD, 1 Int |
| 24. | 26.00 | Week 06, 2002 | SF | @Sea@Sea | 202 Pass, 48 Rush, 2 TD, 1 2-Pt |
| 24. | 26.00 | Week 04, 2001 | SF | CarCar | 212 Pass, 20 Rush, 3 TD, 1 Int |
| 24. | 26.00 | Week 09, 2000 | SF | StLStL | 243 Pass, 51 Rush, 2 TD |
| 24. | 26.00 | Week 03, 2000 | SF | @StL@StL | 290 Pass, 12 Rush, 3 TD, 2 Int |
| 29. | 25.00 | Week 11, 2002 | SF | @SD@SD | 337 Pass, 26 Rush, 2 TD, 1 Int |
| 30. | 24.00 | Week 14, 2008 | TB | @Car@Car | 321 Pass, 6 Rush, 2 TD |
| 30. | 24.00 | Week 16, 2003 | SF | @Phi@Phi | 225 Pass, 20 Rush, 2 TD, 1 2-Pt, 1 Fumb |
| 30. | 24.00 | Week 12, 2002 | SF | PhiPhi | 284 Pass, 13 Rush, 2 TD |
| 30. | 24.00 | Week 08, 2001 | SF | DetDet | 296 Pass, 7 Rush, 3 TD, 2 Int, 1 Fumb |
| 30. | 24.00 | Week 11, 2000 | SF | KCKC | 244 Pass, 37 Rush, 2 TD |
| 35. | 23.00 | Week 07, 2007 | TB | @Det@Det | 316 Pass, 10 Rush, 2 TD, 2 Fumb |
| 35. | 23.00 | Week 08, 2000 | SF | @Car@Car | 307 Pass, 12 Rush, 2 TD, 1 Int |
| 37. | 22.00 | Week 15, 1999 | SF | @Car@Car | 303 Pass, 6 Rush, 2 TD, 1 Int |
| 38. | 21.00 | Week 16, 2008 | TB | SDSD | 232 Pass, 45 Rush, 2 TD, 2 Int |
| 38. | 21.00 | Week 02, 2007 | TB | NONO | 243 Pass, 6 Rush, 2 TD |
| 38. | 21.00 | Week 07, 2004 | PhiPhi | 236 Pass, 21 Rush, 2 TD, 1 Int | |
| 38. | 21.00 | Week 05, 2002 | SF | StLStL | 214 Pass, 12 Rush, 2 TD |
| 42. | 20.00 | Week 01, 2004 | Cle | BalBal | 180 Pass, 13 Rush, 2 TD |
| 42. | 20.00 | Week 17, 2003 | SF | SeaSea | 248 Pass, 15 Rush, 2 TD, 1 Int |
| 42. | 20.00 | Week 07, 2003 | SF | TBTB | 253 Pass, 17 Rush, 2 TD, 1 Int, 1 Fumb |
| 42. | 20.00 | Week 02, 2003 | SF | @StL@StL | 222 Pass, 14 Rush, 6 Receiving, 2 TD, 1 Int |
| 42. | 20.00 | Week 12, 2001 | SF | BufBuf | 189 Pass, 18 Rush, 2 TD |
| 42. | 20.00 | Week 07, 2001 | SF | @Chi@Chi | 269 Pass, 22 Rush, 2 TD, 2 Int |
| 42. | 20.00 | Week 01, 2001 | SF | AtlAtl | 335 Pass, 38 Rush, 1 TD, 1 Int |
| 49. | 19.00 | Week 09, 2008 | TB | @KC@KC | 339 Pass, 1 TD, 1 Int, 1 2-Pt |
| 50. | 18.00 | Week 07, 2008 | TB | SeaSea | 310 Pass, 8 Rush, 1 TD |