*=Offensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 42.00 | Week 10, 2002 * | StL | SDSD | 453 Pass, -1 Rush, 4 TD |
| 2. | 41.00 | Week 16, 2006 | StL | WasWas | 388 Pass, 27 Rush, 4 TD |
| 3. | 32.00 | Week 17, 2004 | StL | NYJNYJ | 450 Pass, 6 Rush, 3 TD, 2 Int |
| 4. | 31.00 | Week 04, 2006 | StL | DetDet | 328 Pass, - 1 Rush, 3 TD |
| 4. | 31.00 | Week 05, 2004 | StL | @Sea@Sea | 325 Pass, 9 Rush, 4 TD, 3 Int |
| 6. | 30.00 | Week 14, 2006 | StL | ChiChi | 356 Pass, 3 TD, 1 Int |
| 6. | 30.00 | Week 06, 2006 | StL | SeaSea | 360 Pass, 3 TD, 1 Int |
| 6. | 30.00 | Week 06, 2002 | StL | OakOak | 186 Pass, -1 Rush, 4 TD, 1 Fumb |
| 9. | 28.00 | Week 03, 2004 | StL | NONO | 358 Pass, 19 Rush, 2 TD, 1 2-Pt, 1 Fumb |
| 9. | 28.00 | Week 06, 2003 | StL | AtlAtl | 352 Pass, 4 Rush, 3 TD, 2 Int |
| 11. | 27.00 | Week 12, 2004 | StL | @GB@GB | 448 Pass, 5 Rush, 2 TD, 1 Int |
| 12. | 26.00 | Week 04, 2003 | StL | AriAri | 272 Pass, -1 Rush, 3 TD, 1 Int |
| 13. | 25.00 | Week 08, 2006 | StL | @SD@SD | 327 Pass, 2 TD |
| 13. | 25.00 | Week 03, 2005 | StL | TenTen | 292 Pass, 3 Rush, 3 TD, 1 Int, 2 Fumb |
| 13. | 25.00 | Week 07, 2003 | StL | GBGB | 247 Pass, 26 Rush, 3 TD, 2 Int |
| 16. | 24.00 | Week 10, 2007 | StL | @NO@NO | 302 Pass, - 1 Rush, 2 TD |
| 16. | 24.00 | Week 04, 2005 | StL | @NYG@NYG | 442 Pass, 9 Rush, 1 Receiving, 2 TD, 3 Int |
| 16. | 24.00 | Week 01, 2005 | StL | @SF@SF | 362 Pass, 8 Rush, 2 TD, 1 Int |
| 19. | 23.00 | Week 05, 2005 | StL | SeaSea | 336 Pass, 2 TD, 1 Int |
| 20. | 22.00 | Week 16, 2007 | StL | PitPit | 208 Pass, 3 TD, 2 Int |
| 20. | 22.00 | Week 07, 2004 | @Mia@Mia | 295 Pass, 15 Rush, 2 TD, 1 Int | |
| 20. | 22.00 | Week 11, 2002 | StL | ChiChi | 347 Pass, -1 Rush, 3 Receiving, 2 TD, 1 Int, 1 Fumb |
| 23. | 21.00 | Week 10, 2009 | StL | NONO | 298 Pass, 7 Rush, 2 TD, 1 Int |
| 23. | 21.00 | Week 05, 2006 | StL | @GB@GB | 220 Pass, 10 Rush, 2 TD |
| 23. | 21.00 | Week 09, 2004 | StL | NENE | 285 Pass, 14 Rush, 2 TD, 1 Int, 1 Fumb |
| 23. | 21.00 | Week 08, 2003 | StL | @Pit@Pit | 375 Pass, 8 Rush, 1 TD |
| 27. | 20.00 | Week 09, 2006 | StL | KCKC | 354 Pass, 11 Rush, 1 TD, 1 Fumb |
| 27. | 20.00 | Week 11, 2005 | StL | AriAri | 224 Pass, 2 TD |
| 27. | 20.00 | Week 15, 2002 | StL | AriAri | 319 Pass, -1 Rush, 2 TD, 2 Int |
| 30. | 19.00 | Week 02, 2007 | StL | SFSF | 368 Pass, 1 TD, 1 Fumb |
| 30. | 19.00 | Week 06, 2004 | StL | TBTB | 264 Pass, - 1 Rush, 2 TD, 1 Int, 1 Fumb |
| 30. | 19.00 | Week 16, 2003 | StL | CinCin | 229 Pass, -2 Rush, 2 TD, 1 Int |
| 30. | 19.00 | Week 15, 2003 | StL | SeaSea | 236 Pass, -1 Rush, 2 TD, 1 Int |
| 30. | 19.00 | Week 13, 2003 | StL | MinMin | 222 Pass, 13 Rush, 2 TD, 1 Int |
| 30. | 19.00 | Week 02, 2003 | StL | SFSF | 236 Pass, 2 TD, 2 Fumb |
| 36. | 18.00 | Week 13, 2006 | StL | AriAri | 314 Pass, 2 TD, 3 Int |
| 37. | 17.00 | Week 09, 2008 | StL | AriAri | 186 Pass, 32 Rush, 2 TD, 2 Int, 1 Fumb |
| 37. | 17.00 | Week 03, 2006 | StL | @Ari@Ari | 309 Pass, - 1 Rush, 1 TD, 1 Fumb |
| 37. | 17.00 | Week 11, 2004 | StL | @Buf@Buf | 287 Pass, 2 TD, 3 Int |
| 37. | 17.00 | Week 11, 2003 | StL | @Chi@Chi | 240 Pass, 2 TD, 2 Int |
| 37. | 17.00 | Week 03, 2003 | StL | @Sea@Sea | 226 Pass, 2 Rush, 2 TD, 2 Int |
| 37. | 17.00 | Week 09, 2002 | StL | @Ari@Ari | 245 Pass, -4 Rush, 2 TD, 2 Int |
| 43. | 16.00 | Week 08, 2008 | StL | @NE@NE | 301 Pass, 1 TD, 1 Int |
| 43. | 16.00 | Week 08, 2007 | StL | CleCle | 310 Pass, 1 TD, 1 Int |
| 43. | 16.00 | Week 10, 2005 | StL | @Sea@Sea | 304 Pass, 9 Rush, 1 TD, 1 Int |
| 43. | 16.00 | Week 10, 2004 | StL | SeaSea | 262 Pass, 1 Rush, 1 TD |
| 43. | 16.00 | Week 09, 2003 | StL | @SF@SF | 378 Pass, 1 TD, 2 Int, 1 Fumb |
| 48. | 15.00 | Week 17, 2008 | StL | @Atl@Atl | 230 Pass, 1 TD |
| 48. | 15.00 | Week 15, 2008 | StL | SeaSea | 207 Pass, 11 Receiving, 1 TD |
| 48. | 15.00 | Week 17, 2006 | StL | @Min@Min | 248 Pass, 1 TD |