*=Defensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 24.00 | Week 14, 2006 * | Buf | @NYJ@NYJ | 6 Tackles, 3 Assists, 3.0 Sacks, 1 FF |
| 2. | 22.00 | Week 16, 2009 | Buf | @Atl@Atl | 4 Tackles, 3.0 Sacks, 2 FF |
| 3. | 21.00 | Week 06, 2004 | Buf | MiaMia | 5 Tackles, 3 Assists, 2.5 Sacks, 1 FF |
| 4. | 20.00 | Week 13, 2003 | Buf | @NYG@NYG | 5 Tackles, 3.0 Sacks, 1 Fum Rcvy |
| 5. | 19.00 | Week 01, 2009 | Buf | @NE@NE | 1 Tackle, 1 Assist, 1.0 Sack, 1 Int, 1 TD, 2 PD |
| 5. | 19.00 | Week 08, 2005 | Buf | @NE@NE | 4 Tackles, 2.0 Sacks, 1 FF, 1 Fum Rcvy, 1 PD |
| 7. | 17.00 | Week 02, 2002 | Buf | @Min@Min | 5 Tackles, 3.0 Sacks |
| 8. | 16.00 | Week 07, 2006 | Buf | NENE | 3 Tackles, 2 Assists, 2.0 Sacks, 1 FF |
| 8. | 16.00 | Week 07, 2004 | @Bal@Bal | 5 Tackles, 2.0 Sacks, 1 FF | |
| 10. | 15.00 | Week 16, 2007 | Buf | NYGNYG | 5 Tackles, 1.0 Sack, 1 FF, 1 Fum Rcvy |
| 10. | 15.00 | Week 08, 2007 | Buf | @NYJ@NYJ | 4 Tackles, 1 Assist, 1.0 Sack, 2 FF |
| 10. | 15.00 | Week 09, 2006 | Buf | GBGB | 4 Tackles, 2.0 Sacks, 1 Fum Rcvy |
| 10. | 15.00 | Week 13, 2005 | Buf | @Mia@Mia | 4 Tackles, 1 Assist, 1.0 Sack, 1 Int1 PD |
| 10. | 15.00 | Week 14, 2001 | Buf | NENE | 5 Tackles, 2 Assists, 2.0 Sacks |
| 15. | 14.00 | Week 16, 2005 | Buf | @Cin@Cin | 3 Tackles, 2 Assists, 2.0 Sacks, 1 PD |
| 15. | 14.00 | Week 10, 2005 | Buf | KCKC | 4 Tackles, 2 Assists, 2.0 Sacks |
| 17. | 13.00 | Week 05, 2004 | Buf | @NYJ@NYJ | 4 Tackles, 1 Assist, 1.0 Sack, 1 FF, 1 PD |
| 17. | 13.00 | Week 03, 2003 | Buf | @Mia@Mia | 5 Tackles, 4 Assists, 1.0 Sack |
| 17. | 13.00 | Week 09, 2001 | Buf | @NE@NE | 2 Tackles, 3 Assists, 2.0 Sacks |
| 20. | 12.00 | Week 13, 2009 | Buf | NYJNYJ | 5 Tackles, 3 Assists, 1.0 Sack |
| 20. | 12.00 | Week 03, 2009 | Buf | NONO | 2 Tackles, 1.0 Sack, 1 FF, 1 Fum Rcvy |
| 20. | 12.00 | Week 13, 2006 | Buf | SDSD | 3 Tackles, 1 Assist, 1.0 Sack, 1 FF, 1 PD |
| 20. | 12.00 | Week 12, 2005 | Buf | CarCar | 4 Tackles, 1 Assist, 1.0 Sack, 1 FF |
| 20. | 12.00 | Week 01, 2005 | Buf | HouHou | 3 Tackles, 1 Assist, 2.0 Sacks |
| 20. | 12.00 | Week 17, 2004 | Buf | PitPit | 6 Tackles, 2 Assists, 1 Fum Rcvy, 1 PD |
| 20. | 12.00 | Week 15, 2004 | Buf | @Cin@Cin | 3 Tackles, 2 Assists, 1.0 Sack, 1 FF |
| 20. | 12.00 | Week 14, 2004 | Buf | CleCle | 2 Tackles, 3 Assists, 1.0 Sack, 1 FF |
| 28. | 11.00 | Week 14, 2007 | Buf | MiaMia | 3 Tackles, 1.0 Sack, 1 FF, 1 PD |
| 28. | 11.00 | Week 15, 2003 | Buf | @Ten@Ten | 3 Tackles, 2.0 Sacks |
| 28. | 11.00 | Week 14, 2003 | Buf | NYJNYJ | 3 Tackles, 1 Assist, 1.0 Sack, 1 FF |
| 31. | 10.00 | Week 14, 2005 | Buf | NENE | 4 Tackles, 2 Assists, 1.0 Sack |
| 31. | 10.00 | Week 07, 2005 | Buf | @Oak@Oak | 6 Tackles, 1.0 Sack |
| 31. | 10.00 | Week 16, 2003 | Buf | MiaMia | 3 Tackles, 3 Assists, 1.0 Sack |
| 31. | 10.00 | Week 15, 2002 | Buf | SDSD | 5 Tackles, 1 Assist, 1.0 Sack |
| 35. | 9.00 | Week 13, 2007 | Buf | @Was@Was | 5 Tackles, 1.0 Sack |
| 35. | 9.00 | Week 12, 2006 | Buf | JacJac | 5 Tackles, 2 Assists, 0.5 Sack |
| 35. | 9.00 | Week 10, 2004 | Buf | @NE@NE | 4 Tackles, 5 Assists |
| 35. | 9.00 | Week 10, 2003 | Buf | @Dal@Dal | 3 Tackles, 1 Assist, 1.0 Sack, 1 PD |
| 35. | 9.00 | Week 05, 2002 | Buf | OakOak | 4 Tackles, 1 Assist, 1.0 Sack |
| 40. | 8.00 | Week 14, 2009 | Buf | @KC@KC | 2 Tackles, 1 Assist, 1.0 Sack, 1 PD |
| 40. | 8.00 | Week 07, 2009 | Buf | @Car@Car | 2 Tackles, 1 Assist, 1.0 Sack, 1 PD |
| 40. | 8.00 | Week 06, 2009 | Buf | @NYJ@NYJ | 5 Tackles, 3 Assists |
| 40. | 8.00 | Week 04, 2009 | Buf | @Mia@Mia | 3 Tackles, 1 Assist, 1.0 Sack |
| 40. | 8.00 | Week 01, 2008 | Buf | SeaSea | 4 Tackles, 1.0 Sack |
| 40. | 8.00 | Week 15, 2007 | Buf | @Cle@Cle | 4 Tackles, 1.0 Sack |
| 40. | 8.00 | Week 03, 2007 | Buf | @NE@NE | 2 Tackles, 3 Assists, 0.5 Sack, 1 PD |
| 40. | 8.00 | Week 16, 2006 | Buf | TenTen | 2 Tackles, 2 Assists, 1.0 Sack |
| 40. | 8.00 | Week 06, 2006 | Buf | @Det@Det | 4 Tackles, 1.0 Sack |
| 40. | 8.00 | Week 01, 2006 | Buf | @NE@NE | 1 Tackle, 1 Assist, 1.0 Sack, 2 PD |
| 40. | 8.00 | Week 13, 2004 | Buf | @Mia@Mia | 2 Tackles, 1 Assist, 0.5 Sack, 1 Fum Rcvy |