*=Defensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 35.00 | Week 04, 2010 * | SD | AriAri | 5 Tackles, 1 Assist, 4.0 Sacks, 1 Int, 1 TD, 2 PD |
| 2. | 20.00 | Week 16, 2012 | SD | @NYJ@NYJ | 2 Tackles, 2 Assists, 2.5 Sacks, 1 FF, 1 Fum Rcvy |
| 2. | 20.00 | Week 06, 2007 | SD | OakOak | 7 Tackles, 2 Assists, 2.0 Sacks, 1 FF |
| 4. | 19.00 | Week 13, 2007 | SD | @KC@KC | 6 Tackles, 3 Assists, 1.5 Sacks, 1 FF, 1 PD |
| 5. | 18.00 | Week 11, 2013 | Den | KCKC | 7 Tackles, 3 Assists, 1.5 Sacks, 2 PD |
| 5. | 18.00 | Week 09, 2009 | SD | @NYG@NYG | 6 Tackles, 2 Assists, 1.0 Sack, 2 FF |
| 5. | 18.00 | Week 14, 2008 | SD | OakOak | 3 Tackles, 2 Assists, 2.5 Sacks, 1 FF |
| 8. | 17.00 | Week 01, 2013 | Den | BalBal | 3 Tackles, 1 Assist, 2.5 Sacks, 1 FF |
| 8. | 17.00 | Week 10, 2006 | SD | @Cin@Cin | 2 Tackles, 5 Assists, 1.0 Sack, 1 FF, 1 Fum Rcvy |
| 8. | 17.00 | Week 06, 2006 | SD | @SF@SF | 4 Tackles, 1 Assist, 2.0 Sacks, 1 FF, 1 PD |
| 11. | 16.00 | Week 12, 2006 | SD | OakOak | 6 Tackles, 3 Assists, 1.5 Sacks, 1 PD |
| 12. | 14.00 | Week 04, 2012 | SD | @KC@KC | 4 Tackles, 1.0 Sack, 1 FF, 1 Fum Rcvy |
| 12. | 14.00 | Week 15, 2011 | SD | BalBal | 4 Tackles, 2 Assists, 0.5 Sack, 1 Int, 1 PD |
| 12. | 14.00 | Week 07, 2011 | SD | @NYJ@NYJ | 4 Tackles, 2 Assists, 2.0 Sacks |
| 12. | 14.00 | Week 08, 2009 | SD | OakOak | 2 Tackles, 1 Assist, 2.0 Sacks, 1 FF |
| 12. | 14.00 | Week 07, 2009 | SD | @KC@KC | 6 Tackles, 2.0 Sacks |
| 12. | 14.00 | Week 04, 2006 | SD | @Bal@Bal | 7 Tackles, 1.0 Sack, 1 FF |
| 12. | 14.00 | Week 09, 2005 | SD | @NYJ@NYJ | 6 Tackles, 2.0 Sacks |
| 19. | 13.00 | Week 03, 2007 | SD | @GB@GB | 5 Tackles, 1 Assist, 1.5 Sacks, 1 PD |
| 20. | 12.00 | Week 13, 2009 | SD | @Cle@Cle | 2 Tackles, 2 Assists, 1.0 Sack, 1 FF, 1 PD |
| 20. | 12.00 | Week 01, 2008 | SD | CarCar | 8 Tackles, 1 Assist, 1 Fum Rcvy |
| 20. | 12.00 | Week 15, 2007 | SD | DetDet | 1 Int, 1 TD, 1 PD |
| 23. | 11.00 | Week 05, 2013 | Den | @Dal@Dal | 3 Tackles, 2.0 Sacks |
| 23. | 11.00 | Week 11, 2012 | SD | @Den@Den | 4 Tackles, 1 Assist, 1.0 Sack, 1 Safety |
| 23. | 11.00 | Week 13, 2010 | SD | OakOak | 7 Tackles, 1 Assist, 1 Fum Rcvy |
| 23. | 11.00 | Week 11, 2010 | SD | DenDen | 3 Tackles, 2.0 Sacks |
| 23. | 11.00 | Week 04, 2007 | SD | KCKC | 3 Tackles, 1 Assist, 1.0 Sack, 1 FF |
| 23. | 11.00 | Week 11, 2006 | SD | @Den@Den | 3 Tackles, 1 Assist, 1.0 Sack, 1 FF |
| 23. | 11.00 | Week 01, 2006 | SD | @Oak@Oak | 3 Tackles, 1.5 Sacks, 2 PD |
| 23. | 11.00 | Week 11, 2005 | SD | BufBuf | 4 Tackles, 1.0 Sack, 1 FF |
| 31. | 10.00 | Week 01, 2012 | SD | @Oak@Oak | 2 Tackles, 2.0 Sacks |
| 31. | 10.00 | Week 11, 2009 | SD | @Den@Den | 2 Tackles, 1 Assist, 1.0 Sack, 1 FF |
| 31. | 10.00 | Week 04, 2008 | SD | @Oak@Oak | 2 Tackles, 2 Assists, 1.5 Sacks |
| 31. | 10.00 | Week 16, 2007 | SD | DenDen | 4 Tackles, 2 Assists, 1.0 Sack |
| 31. | 10.00 | Week 11, 2007 | SD | @Jac@Jac | 10 Tackles |
| 36. | 9.00 | Week 08, 2012 | SD | @Cle@Cle | 2 Tackles, 4 Assists, 0.5 Sack, 1 PD |
| 36. | 9.00 | Week 02, 2011 | SD | @NE@NE | 3 Tackles, 1 Assist, 1.0 Sack, 1 PD |
| 36. | 9.00 | Week 01, 2011 | SD | MinMin | 2 Tackles, 1 Assist, 1 Int, 1 PD |
| 36. | 9.00 | Week 12, 2010 | SD | @Ind@Ind | 4 Tackles, 1 Assist, 1.0 Sack |
| 36. | 9.00 | Week 07, 2010 | SD | NENE | 5 Tackles, 1.0 Sack |
| 36. | 9.00 | Week 01, 2010 | SD | @KC@KC | 5 Tackles, 1.0 Sack |
| 36. | 9.00 | Week 04, 2009 | SD | @Pit@Pit | 5 Tackles, 1 Assist, 1 FF |
| 36. | 9.00 | Week 07, 2008 | SD | @Buf@Buf | 4 Tackles, 4 Assists, 1 PD |
| 36. | 9.00 | Week 03, 2008 | SD | NYJNYJ | 4 Tackles, 1 Assist, 1.0 Sack |
| 36. | 9.00 | Week 10, 2007 | SD | IndInd | 2 Tackles, 1 Assist, 1 Int, 1 PD |
| 36. | 9.00 | Week 13, 2006 | SD | @Buf@Buf | 4 Tackles, 1 Assist, 1.0 Sack |
| 36. | 9.00 | Week 05, 2006 | SD | PitPit | 5 Tackles, 1.0 Sack |
| 36. | 9.00 | Week 17, 2005 | SD | DenDen | 2 Tackles, 1.0 Sack, 1 FF |
| 49. | 8.00 | Week 04, 2013 | Den | PhiPhi | 4 Tackles, 1.0 Sack |
| 49. | 8.00 | Week 05, 2012 | SD | @NO@NO | 3 Tackles, 1 Assist, 1.0 Sack |