*=Defensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 23.00 | Week 14, 2006 | SD | DenDen | 4 Tackles, 1 Assist, 2.0 Sacks, 2 FF, 1 Fum Rcvy, 1 PD |
| 2. | 21.00 | Week 13, 2007 | SD | @KC@KC | 6 Tackles, 3.0 Sacks, 1 Fum Rcvy |
| 2. | 21.00 | Week 13, 2006 | SD | @Buf@Buf | 6 Tackles, 2.0 Sacks, 2 FF, 1 PD |
| 4. | 19.00 | Week 16, 2006 | SD | @Sea@Sea | 4 Tackles, 1 Assist, 3.0 Sacks, 2 PD |
| 5. | 18.00 | Week 01, 2006 | SD | @Oak@Oak | 6 Tackles, 3.0 Sacks |
| 6. | 17.00 | Week 06, 2007 | SD | OakOak | 4 Tackles, 2 Assists, 2.5 Sacks, 1 PD |
| 6. | 17.00 | Week 08, 2006 | SD | StLStL | 5 Tackles, 3.0 Sacks |
| 8. | 16.00 | Week 02, 2007 | SD | @NE@NE | 4 Tackles, 1 Assist, 2.0 Sacks, 1 FF |
| 8. | 16.00 | Week 08, 2005 | SD | KCKC | 4 Tackles, 1 Assist, 2.0 Sacks, 1 FF |
| 10. | 15.00 | Week 08, 2009 | SD | OakOak | 7 Tackles, 2.0 Sacks |
| 10. | 15.00 | Week 15, 2005 | SD | 00 | 4 Tackles, 3 Assists, 2.0 Sacks |
| 12. | 14.00 | Week 09, 2009 | SD | @NYG@NYG | 2 Tackles, 1 Assist, 2.0 Sacks, 1 Fum Rcvy |
| 12. | 14.00 | Week 12, 2007 | SD | BalBal | 5 Tackles, 2 Assists, 1.0 Sack, 1 FF |
| 12. | 14.00 | Week 04, 2007 | SD | KCKC | 8 Tackles, 2 Assists, 1.0 Sack |
| 15. | 13.00 | Week 14, 2007 | SD | @Ten@Ten | 4 Tackles, 1 Assist, 2.0 Sacks |
| 15. | 13.00 | Week 17, 2006 | SD | AriAri | 5 Tackles, 3 Assists, 1.0 Sack, 1 PD |
| 15. | 13.00 | Week 09, 2005 | SD | @NYJ@NYJ | 7 Tackles, 2 Assists, 1.0 Sack |
| 18. | 12.00 | Week 11, 2005 | SD | BufBuf | 4 Tackles, 2.0 Sacks |
| 19. | 11.00 | Week 06, 2006 | SD | @SF@SF | 6 Tackles, 1 Assist, 1.0 Sack |
| 20. | 10.00 | Week 05, 2005 | SD | PitPit | 1 Tackle, 1 Assist, 1.0 Sack, 1 FF, 1 PD |
| 21. | 9.00 | Week 08, 2007 | SD | HouHou | 6 Tackles, 1 Assist, 2 PD |
| 21. | 9.00 | Week 07, 2006 | SD | @KC@KC | 7 Tackles, 1 Assist, 1 PD |
| 21. | 9.00 | Week 07, 2005 | SD | @Phi@Phi | 5 Tackles, 1.0 Sack |
| 24. | 8.00 | Week 02, 2006 | SD | TenTen | 1 Assist, 1 Int2 PD |
| 24. | 8.00 | Week 17, 2005 | SD | DenDen | 1 Tackle, 2 Assists, 1.0 Sack, 1 PD |
| 26. | 7.00 | Week 17, 2012 | Buf | NYJNYJ | 5 Tackles, 2 Assists |
| 26. | 7.00 | Week 04, 2011 | Buf | @Cin@Cin | 2 Tackles, 1 Assist, 1.0 Sack |
| 26. | 7.00 | Week 17, 2007 | SD | @Oak@Oak | 2 Tackles, 1 Assist, 1.0 Sack |
| 29. | 6.00 | Week 11, 2012 | Buf | MiaMia | 2 Tackles, 1.0 Sack |
| 29. | 6.00 | Week 15, 2006 | SD | KCKC | 2 Tackles, 4 Assists |
| 29. | 6.00 | Week 04, 2006 | SD | @Bal@Bal | 2 Tackles, 1.0 Sack |
| 29. | 6.00 | Week 13, 2005 | SD | OakOak | 4 Tackles, 2 Assists |
| 33. | 5.00 | Week 05, 2011 | Buf | PhiPhi | 1 Tackle, 1.0 Sack |
| 33. | 5.00 | Week 07, 2009 | SD | @KC@KC | 5 Tackles |
| 33. | 5.00 | Week 06, 2009 | SD | DenDen | 3 Tackles, 2 Assists |
| 33. | 5.00 | Week 01, 2009 | SD | @Oak@Oak | 3 Tackles, 2 Assists |
| 33. | 5.00 | Week 16, 2007 | SD | DenDen | 1 Tackle, 1 Assist, 1 Fum Rcvy |
| 33. | 5.00 | Week 09, 2007 | SD | @Min@Min | 4 Tackles, 1 Assist |
| 33. | 5.00 | Week 05, 2006 | SD | PitPit | 2 Tackles, 1 Assist, 0.5 Sack |
| 33. | 5.00 | Week 16, 2005 | SD | @KC@KC | 5 Tackles |
| 41. | 4.00 | Week 13, 2012 | Buf | JacJac | 2 Assists, 0.5 Sack |
| 41. | 4.00 | Week 02, 2011 | Buf | OakOak | 3 Tackles, 1 Assist |
| 43. | 3.00 | Week 16, 2012 | Buf | @Mia@Mia | 2 Tackles, 1 PD |
| 43. | 3.00 | Week 02, 2010 | SD | JacJac | 3 Tackles |
| 43. | 3.00 | Week 16, 2009 | SD | @Ten@Ten | 3 Tackles |
| 43. | 3.00 | Week 10, 2007 | SD | IndInd | 3 Tackles |
| 43. | 3.00 | Week 05, 2007 | SD | @Den@Den | 3 Tackles |
| 43. | 3.00 | Week 01, 2007 | SD | ChiChi | 3 Tackles |
| 43. | 3.00 | Week 14, 2005 | SD | MiaMia | 2 Tackles, 1 Assist |
| 43. | 3.00 | Week 06, 2005 | SD | @Oak@Oak | 1 Tackle, 1 Assist, 1 PD |