*=Defensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 19.00 | Week 13, 2009 | Buf | NYJNYJ | 4 Tackles, 4 Assists, 2.0 Sacks, 1 FF |
| 2. | 18.00 | Week 12, 2010 | Buf | PitPit | 8 Tackles, 2 Assists, 2.0 Sacks |
| 3. | 17.00 | Week 08, 2010 | Buf | @KC@KC | 6 Tackles, 3 Assists, 2.0 Sacks |
| 4. | 15.00 | Week 08, 2013 | Buf | @NO@NO | 6 Tackles, 3 Assists, 1.5 Sacks |
| 5. | 14.00 | Week 06, 2018 | Buf | @Hou@Hou | 1 Tackle, 2 Assists, 2.0 Sacks, 1 FF |
| 5. | 14.00 | Week 11, 2013 | Buf | NYJNYJ | 3 Tackles, 2.0 Sacks, 1 FF |
| 5. | 14.00 | Week 05, 2009 | Buf | CleCle | 7 Tackles, 3 Assists, 1.0 Sack |
| 8. | 13.00 | Week 12, 2018 | Buf | JacJac | 4 Tackles, 3 Assists, 1.5 Sacks |
| 8. | 13.00 | Week 16, 2013 | Buf | MiaMia | 4 Tackles, 1 Assist, 2.0 Sacks |
| 10. | 12.00 | Week 05, 2013 | Buf | @Cle@Cle | 2 Tackles, 6 Assists, 1.0 Sack |
| 11. | 11.00 | Week 02, 2012 | Buf | KCKC | 2 Tackles, 1 Assist, 2.0 Sacks |
| 11. | 11.00 | Week 17, 2009 | Buf | IndInd | 5 Tackles, 2 Assists, 1.0 Sack |
| 13. | 10.00 | Week 15, 2016 | Buf | CleCle | 3 Tackles, 1 Assist, 1.5 Sacks |
| 13. | 10.00 | Week 01, 2013 | Buf | NENE | 3 Tackles, 3 Assists, 1.0 Sack |
| 13. | 10.00 | Week 17, 2008 | Buf | NENE | 6 Tackles, 1.0 Sack |
| 16. | 9.00 | Week 13, 2016 | Buf | @Oak@Oak | 7 Tackles, 2 Assists |
| 16. | 9.00 | Week 12, 2016 | Buf | JacJac | 4 Tackles, 5 Assists |
| 16. | 9.00 | Week 10, 2013 | Buf | @Pit@Pit | 4 Tackles, 1 Assist, 1.0 Sack |
| 16. | 9.00 | Week 03, 2010 | Buf | @NE@NE | 3 Tackles, 1 Assist, 1.0 Sack, 1 PD |
| 16. | 9.00 | Week 02, 2008 | Buf | @Jac@Jac | 4 Tackles, 1 Assist, 1.0 Sack |
| 16. | 9.00 | Week 01, 2008 | Buf | SeaSea | 1 Tackle, 2 Assists, 1.5 Sacks |
| 22. | 8.00 | Week 16, 2017 | Buf | @NE@NE | 2 Tackles, 2 Assists, 1.0 Sack |
| 22. | 8.00 | Week 03, 2017 | Buf | DenDen | 4 Tackles, 1.0 Sack |
| 22. | 8.00 | Week 09, 2016 | Buf | @Sea@Sea | 3 Tackles, 1 Assist, 1.0 Sack |
| 22. | 8.00 | Week 03, 2016 | Buf | AriAri | 1 Tackle, 3 Assists, 1.0 Sack |
| 22. | 8.00 | Week 05, 2015 | Buf | @Ten@Ten | 3 Tackles, 1 Assist, 1.0 Sack |
| 22. | 8.00 | Week 13, 2014 | Buf | CleCle | 2 Tackles, 1 Assist, 1.0 Sack, 1 PD |
| 22. | 8.00 | Week 08, 2014 | Buf | @NYJ@NYJ | 1 Tackle, 1 Assist, 1.5 Sacks |
| 22. | 8.00 | Week 02, 2014 | Buf | MiaMia | 3 Tackles, 1 Assist, 1.0 Sack |
| 22. | 8.00 | Week 15, 2013 | Buf | @Jac@Jac | 4 Tackles, 1.0 Sack |
| 22. | 8.00 | Week 06, 2013 | Buf | CinCin | 2 Tackles, 4 Assists, 0.5 Sack |
| 22. | 8.00 | Week 04, 2012 | Buf | NENE | 3 Tackles, 2 Assists, 0.5 Sack, 1 PD |
| 22. | 8.00 | Week 12, 2009 | Buf | MiaMia | 5 Tackles, 3 Assists |
| 22. | 8.00 | Week 13, 2008 | Buf | SFSF | 3 Tackles, 2 Assists, 1 FF |
| 22. | 8.00 | Week 14, 2007 | Buf | MiaMia | 5 Tackles, 1 Assist, 0.5 Sack |
| 22. | 8.00 | Week 08, 2007 | Buf | @NYJ@NYJ | 2 Tackles, 2 Assists, 1.0 Sack |
| 37. | 7.00 | Week 10, 2017 | Buf | NONO | 2 Tackles, 2 Assists, 1 Fum Rcvy |
| 37. | 7.00 | Week 01, 2014 | Buf | @CHI@CHI | 1 Assist, 1 Int, 1 PD |
| 37. | 7.00 | Week 02, 2013 | Buf | CarCar | 5 Tackles, 1 Assist, 1 PD |
| 37. | 7.00 | Week 07, 2012 | Buf | TenTen | 2 Tackles, 3 Assists, 0.5 Sack |
| 37. | 7.00 | Week 03, 2012 | Buf | @Cle@Cle | 2 Tackles, 1 Assist, 1.0 Sack |
| 37. | 7.00 | Week 01, 2010 | Buf | MiaMia | 3 Tackles, 4 Assists |
| 37. | 7.00 | Week 03, 2009 | Buf | NONO | 4 Tackles, 3 Assists |
| 37. | 7.00 | Week 17, 2006 | Buf | @Bal@Bal | 5 Tackles, 2 Assists |
| 45. | 6.00 | Week 01, 2018 | Buf | BalBal | 3 Tackles, 1 Assist, 0.5 Sack |
| 45. | 6.00 | Week 13, 2017 | Buf | NENE | 2 Tackles, 1.0 Sack |
| 45. | 6.00 | Week 02, 2017 | Buf | @Car@Car | 6 Assists |
| 45. | 6.00 | Week 08, 2016 | Buf | NENE | 2 Tackles, 1.0 Sack |
| 45. | 6.00 | Week 16, 2014 | Buf | @Oak@Oak | 3 Tackles, 1 Assist, 0.5 Sack |
| 45. | 6.00 | Week 09, 2010 | Buf | ChiChi | 4 Tackles, 2 Assists |