*=Defensive Player of the Week
| Rank | Score | Week | Proteam | Opponent | Breakdown |
| 1. | 20.00 | Week 12, 2008 | Buf | @KC@KC | 2 Tackles, 2 Int, 1 TD, 2 PD |
| 2. | 18.00 | Week 16, 2013 | Buf | MiaMia | 4 Tackles, 2 Assists, 1 Int, 1 Fum Rcvy, 4 PD |
| 3. | 16.00 | Week 07, 2014 | Buf | MinMin | 4 Tackles, 2 Int, 2 PD |
| 3. | 16.00 | Week 01, 2014 | Buf | @CHI@CHI | 13 Tackles, 1 FF |
| 3. | 16.00 | Week 13, 2013 | Buf | AtlAtl | 8 Tackles, 2 Assists, 1 Fum Rcvy, 3 PD |
| 6. | 14.00 | Week 14, 2016 | Phi | WasWas | 5 Tackles, 1 Int, 4 PD |
| 7. | 13.00 | Week 13, 2010 | Buf | @Min@Min | 6 Tackles, 1 Assist, 1 Int, 1 PD |
| 8. | 12.00 | Week 17, 2015 | Buf | NYJNYJ | 5 Tackles, 1 Int, 2 PD |
| 8. | 12.00 | Week 14, 2015 | Buf | @Phi@Phi | 4 Tackles, 1 Assist, 1 Int, 2 PD |
| 8. | 12.00 | Week 15, 2013 | Buf | @Jac@Jac | 8 Tackles, 1 FF, 1 PD |
| 8. | 12.00 | Week 03, 2011 | Buf | NENE | 3 Tackles, 3 Assists, 1 Int, 1 PD |
| 12. | 10.00 | Week 01, 2013 | Buf | NENE | 5 Tackles, 1 Assist, 4 PD |
| 13. | 9.00 | Week 16, 2016 | Phi | NYGNYG | 5 Tackles, 1 Assist, 3 PD |
| 13. | 9.00 | Week 13, 2016 | Phi | @Cin@Cin | 7 Tackles, 2 Assists |
| 13. | 9.00 | Week 04, 2014 | Buf | @Hou@Hou | 3 Tackles, 1 Int, 1 PD |
| 13. | 9.00 | Week 02, 2014 | Buf | MiaMia | 3 Tackles, 1 Int, 1 PD |
| 13. | 9.00 | Week 08, 2013 | Buf | @NO@NO | 4 Tackles, 2 Assists, 1 Fum Rcvy |
| 13. | 9.00 | Week 06, 2013 | Buf | CinCin | 7 Tackles, 1 Assist, 1 PD |
| 19. | 8.00 | Week 10, 2016 | Phi | AtlAtl | 1 Int, 3 PD |
| 19. | 8.00 | Week 08, 2016 | Phi | @Dal@Dal | 3 Tackles, 3 Assists, 2 PD |
| 19. | 8.00 | Week 02, 2013 | Buf | CarCar | 4 Tackles, 1 Assist, 3 PD |
| 19. | 8.00 | Week 16, 2011 | Buf | DenDen | 2 Tackles, 1 TD |
| 19. | 8.00 | Week 01, 2011 | Buf | @KC@KC | 4 Tackles, 1 Fum Rcvy, 1 PD |
| 19. | 8.00 | Week 14, 2010 | Buf | CleCle | 1 Tackle, 1 Int, 2 PD |
| 19. | 8.00 | Week 05, 2010 | Buf | JacJac | 6 Tackles, 2 Assists |
| 19. | 8.00 | Week 04, 2010 | Buf | NYJNYJ | 4 Tackles, 2 Assists, 2 PD |
| 19. | 8.00 | Week 11, 2008 | Buf | CleCle | 1 Tackle, 1 TD, 1 PD |
| 19. | 8.00 | Week 04, 2008 | Buf | @StL@StL | 2 Tackles, 1 FF, 1 Fum Rcvy |
| 29. | 7.00 | Week 09, 2015 | Buf | MiaMia | 6 Tackles, 1 PD |
| 29. | 7.00 | Week 10, 2014 | Buf | KCKC | 6 Tackles, 1 PD |
| 29. | 7.00 | Week 11, 2012 | Buf | MiaMia | 1 Tackle, 1 TD |
| 29. | 7.00 | Week 02, 2010 | Buf | @GB@GB | 4 Tackles, 1 FF |
| 33. | 6.00 | Week 15, 2015 | Buf | @Was@Was | 1 Tackle, 4 Assists, 1 PD |
| 33. | 6.00 | Week 08, 2014 | Buf | @NYJ@NYJ | 3 Tackles, 1 Assist, 2 PD |
| 33. | 6.00 | Week 05, 2014 | Buf | @Det@Det | 5 Tackles, 1 PD |
| 33. | 6.00 | Week 17, 2013 | Buf | @NE@NE | 3 Tackles, 3 Assists |
| 33. | 6.00 | Week 10, 2013 | Buf | @Pit@Pit | 3 Tackles, 1 Fum Rcvy |
| 33. | 6.00 | Week 03, 2012 | Buf | @Cle@Cle | 1 Int, 1 PD |
| 33. | 6.00 | Week 02, 2012 | Buf | KCKC | 1 TD |
| 33. | 6.00 | Week 04, 2011 | Buf | @Cin@Cin | 3 Tackles, 2 Assists, 1 PD |
| 33. | 6.00 | Week 02, 2011 | Buf | OakOak | 6 Tackles |
| 33. | 6.00 | Week 15, 2010 | Buf | @Mia@Mia | 6 Tackles |
| 33. | 6.00 | Week 08, 2010 | Buf | @KC@KC | 5 Tackles, 1 Assist |
| 33. | 6.00 | Week 01, 2009 | Buf | @NE@NE | 5 Tackles, 1 Assist |
| 33. | 6.00 | Week 16, 2008 | Buf | @Den@Den | 6 Tackles |
| 33. | 6.00 | Week 15, 2008 | Buf | @NYJ@NYJ | 3 Tackles, 2 Assists, 1 PD |
| 47. | 5.00 | Week 12, 2016 | Phi | GBGB | 5 Tackles |
| 47. | 5.00 | Week 16, 2015 | Buf | DalDal | 2 Tackles, 3 PD |
| 47. | 5.00 | Week 11, 2015 | Buf | @NE@NE | 1 Tackle, 1 Assist, 1 Fum Rcvy |
| 47. | 5.00 | Week 10, 2012 | Buf | @NE@NE | 4 Tackles, 1 PD |