| Position | Starters | Proteam | TW | PPG | Total | Breakdown |
|---|---|---|---|---|---|---|
| QB | Lamar Jackson | Bal | DNP | 22.92 | 274.98 | Did Not Play |
| RB | Nick Chubb | Cle | 25.9 | 16.17 | 194.00 | 126 Rush, 58 Receiving, 3 Rec, 1 TD |
| RB | Jeff Wilson | SF | 13.2 | 6.86 | 48.00 | 45 Rush, 12 Receiving, 3 Rec, 1 TD |
| WR | Justin Jefferson | Min | 15.6 | 16.60 | 249.00 | 116 Receiving, 8 Rec |
| WR | Tyler Johnson | TB | 0.0 | 2.82 | 42.30 | Played, No Stats |
| WR | Josh Palmer | LAC | 12.8 | 4.05 | 60.80 | 43 Receiving, 5 Rec, 1 TD |
| TE | Cole Kmet | Chi | 6.9 | 5.36 | 80.40 | 49 Receiving, 4 Rec |
| HB (RB) | Chase Edmonds | Ari | 22.7 | 10.19 | 112.10 | 56 Rush, 71 Receiving, 8 Rec, 1 TD |
| PK | Evan McPherson | Cin | 11.0 | 9.40 | 141.00 | 2 FG(<40), 5 XP |
| DL | Brian Burns | Car | 3.0 | 6.13 | 92.00 | 3 Assists |
| DL | Maxx Crosby | LV | 7.0 | 5.00 | 75.00 | 3 Tackles, 1.0 Sack |
| DL | Jeffery Simmons | Ten | 2.0 | 5.87 | 88.00 | 2 Tackles |
| LB | Cole Holcomb | Was | DNP | 11.00 | 154.00 | Did Not Play |
| LB | Roquan Smith | Chi | 9.0 | 11.47 | 172.00 | 7 Tackles, 2 Assists |
| LB | T.J. Watt | Pit | 1.0 | 11.46 | 149.00 | 1 Tackle |
| CB | Adoree' Jackson | Ten | DNP | 6.18 | 68.00 | Did Not Play |
| S | Jordan Fuller | LAR | 5.0 | 7.00 | 105.00 | 1 Tackle, 4 Assists |
| Position | 1st Backups | Proteam | TW | PPG | Total | Breakdown |
| QB | Ben Roethlisberger | Pit | 9.36 | 17.49 | 244.92 | 159 Pass, 1 TD, 1 Int, 1 Fumb |
| RB | Duke Johnson | Mia | 0(3.9) | 2.21 | 30.90 | 39 Rush |
| WR | Kenny Golladay | NYG | 0(3.7) | 5.57 | 66.90 | 22 Receiving, 3 Rec |
| HB (RB) | Chuba Hubbard | Car | 0(0.9) | 6.61 | 99.20 | 9 Rush |
| PK | Brandon McManus | Den | 0(10.0) | 7.47 | 112.00 | 1 FG(40-49), 1 FG(50-59), 1 XP |
| DL | A'Shawn Robinson | LAR | 0(2.0) | 3.93 | 59.00 | 2 Tackles |
| LB | C.J. Mosley | NYJ | 17.0 | 11.29 | 158.00 | 6 Tackles, 4 Assists, 1.0 Sack, 1 FF |
| CB | Darius Slay | Phi | 2.0 | 6.47 | 97.00 | 1 Tackle, 1 Assist |
| S | Malcolm Jenkins | NO | DNP | 6.57 | 92.00 | Did Not Play |
| Position | 2nd Backups | Proteam | TW | PPG | Total | Breakdown |
| QB | Jimmy Garoppolo | SF | 0(15.18) | 18.27 | 255.76 | 322 Pass, 3 Rush, 1 TD, 2 Int |
| RB | Myles Gaskin | Mia | 0(2.1) | 9.69 | 145.30 | 10 Rush, 6 Receiving, 1 Rec |
| WR | Bryan Edwards | LV | DNP | 5.99 | 83.80 | Did Not Play |
| Offense = 117.46 Defense = 46 Total = 163.46 | ||||||
| Position | Bench | Proteam | TW | PPG | Total | Breakdown |
| RB | Kareem Hunt | Cle | DNP | 12.38 | 99.00 | Did Not Play |
| RB | Trey Sermon | SF | DNP | 2.98 | 26.80 | Did Not Play |
| WR | Gabriel Davis | Buf | DNP | 6.96 | 97.50 | Did Not Play |
| TE | Travis Kelce | KC | DNP | 13.96 | 195.50 | Did Not Play |
| Position | Injured Reserve | Proteam | TW | PPG | Total | Breakdown |
| WR | DeAndre Hopkins | Ari | DNP | 12.62 | 126.20 | Did Not Play |