| Pos. | Starters | Proteam | TW | PPG | Total | Breakdown |
| QB | Josh Allen | Buf | 21.16 | 26.66 | 426.58 | 169 Pass, 44 Rush, 2 TD, 1 Int |
| RB | David Montgomery | Det | 12.50 | 14.63 | 190.20 | 65 Rush, 1 TD |
| RB | Rachaad White | TB | 7.60 | 14.16 | 226.60 | 42 Rush, 24 Receiving, 4 Rec, 1 Fumb |
| WR | Brandon Aiyuk | SF | 20.90 | 13.91 | 208.70 | 114 Receiving, 7 Rec, 1 TD |
| WR | Calvin Ridley | Jac | 5.90 | 10.77 | 172.30 | 39 Receiving, 4 Rec |
| WR | Amon-Ra St. Brown | Det | 19.10 | 16.57 | 248.50 | 11 Rush, 90 Receiving, 6 Rec, 1 TD |
| TE | Jake Ferguson | Dal | 5.30 | 8.23 | 131.70 | 33 Receiving, 4 Rec |
| HB | Nico Collins | Hou | 12.20 | 13.46 | 188.40 | 7 Rush, 80 Receiving, 7 Rec |
| PK | Ka'imi Fairbairn | Hou | 16.00 | 8.92 | 107.00 | 3 FG(<40), 1 FG(50-59), 2 XP |
| DL | Josh Allen | Jac | 18.00 | 8.75 | 140.00 | 5 Tackles, 1 Assist, 3.0 Sacks |
| DL | Montez Sweat | Chi | 1.00 | 7.25 | 116.00 | 1 Assist |
| DL | T.J. Watt | Pit | 2.00 | 10.50 | 168.00 | 1 Tackle, 1 Assist |
| LB | Foyesade Oluokun | Jac | 7.00 | 12.88 | 206.00 | 3 Tackles, 3 Assists, 1 PD |
| LB | Robert Spillane | LV | 6.00 | 10.94 | 175.00 | 5 Tackles, 1 Assist |
| LB | Quincy Williams | NYJ | 10.00 | 10.06 | 161.00 | 5 Tackles, 2 Assists, 1 FF |
| CB | Camryn Bynum | Min | 10.00 | 10.00 | 160.00 | 5 Tackles, 5 Assists |
| S | Kevin Byard | Phi | 11.00 | 8.33 | 125.00 | 8 Tackles, 3 Assists |
| Pos. | 1st Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Tyrod Taylor | NYG | 0(20.76) | 7.06 | 77.66 | 319 Pass, 40 Rush, 1 TD, 1 Int |
| RB | Jerome Ford | Cle | 0(25.10) | 11.50 | 184.00 | 64 Rush, 57 Receiving, 2 Rec, 2 TD |
| WR | Jayden Reed | GB | 0(23.90) | 11.47 | 172.00 | 89 Receiving, 6 Rec, 2 TD |
| WR | DeVante Parker | NE | 0(2.00) | 4.57 | 54.80 | 15 Receiving, 1 Rec |
| PK | Brandon McManus | Jac | 0(14.00) | 8.56 | 137.00 | 4 FG(<40), 2 XP |
| DL | Alex Highsmith | Pit | 0 | 6.69 | 107.00 | Played, No Stats |
| LB | Nate Landman | Atl | 0(6.00) | 8.20 | 123.00 | 5 Tackles, 1 Assist |
| CB | L'Jarius Sneed | KC | 0(4.00) | 6.69 | 107.00 | 2 Tackles, 1 Assist, 1 PD |
| S | Kamren Curl | Was | 0(9.00) | 8.19 | 131.00 | 6 Tackles, 3 Assists |
| Pos. | 2nd Backup | Proteam | TW | PPG | Total | Breakdown |
| RB | Tank Bigsby | Jac | 0(3.20) | 1.42 | 22.70 | 32 Rush |
| WR | Rashod Bateman | Bal | 0(7.40) | 4.03 | 60.50 | 54 Receiving, 4 Rec |
| RB | D'Ernest Johnson | Jac | 0 | 1.87 | 29.90 | Played, No Stats |
| DL | Javon Hargrave | SF | 0(1.00) | 4.87 | 73.00 | 1 Assist |
| Offense = 120.66 Defense = 65 Total = 185.66 | ||||||
| Pos. | Bench | Proteam | TW | PPG | Total | Breakdown |
| RB | Miles Sanders | Car | 3.20 | 4.95 | 74.30 | 10 Rush, 12 Receiving, 2 Rec |
| RB | Isaiah Spiller | LAC | 1.90 | 1.78 | 16.00 | -1 Rush, 10 Receiving, 2 Rec |
| WR | Treylon Burks | Ten | 2.10 | 3.19 | 31.90 | 11 Receiving, 2 Rec |
| Pos. | Injured List | Proteam | TW | PPG | Total | Breakdown |
| LB | Jordan Hicks | Min | 4.00 | 10.75 | 129.00 | 11 Receiving, 2 Rec |