| Pos. | Starters | Proteam | TW | PPG | Total | Breakdown |
| QB | Jared Goff | Det | 28.40 | 21.02 | 336.36 | 255 Pass, 2 Rush, 3 TD |
| RB | Christian McCaffrey | SF | 28.30 | 18.78 | 300.46 | 121 Rush, 72 Receiving, 6 Rec, 1 TD |
| RB | Joe Mixon | Cin | DNP | 14.94 | 194.20 | Did Not Play |
| WR | Davante Adams | LV | 30.80 | 17.23 | 275.70 | 153 Receiving, 7 Rec, 2 TD |
| WR | Drake London | Atl | 7.20 | 8.16 | 130.60 | 47 Receiving, 5 Rec |
| WR | Jaylen Waddle | Mia | 6.70 | 13.43 | 214.90 | 52 Receiving, 3 Rec |
| TE | Logan Thomas | Was | 8.60 | 4.25 | 55.20 | 56 Receiving, 6 Rec |
| HB | Tyler Allgeier | Atl | 16.00 | 9.19 | 137.90 | 83 Rush, 12 Receiving, 1 Rec, 1 TD |
| PK | Younghoe Koo | Atl | 8.00 | 8.44 | 135.00 | 2 FG(<40), 2 XP |
| DL | B.J. Hill | Cin | DNP | 5.93 | 89.00 | Did Not Play |
| DL | Zach Sieler | Mia | 10.00 | 5.75 | 92.00 | 3 Tackles, 3 Assists, 1.0 Sack |
| DL | Grover Stewart | Ind | 2.00 | 5.56 | 89.00 | 1 Tackle, 1 Assist |
| LB | C.J. Mosley | NYJ | 9.00 | 10.63 | 170.00 | 8 Tackles, 1 Assist |
| LB | Foyesade Oluokun | Jac | 10.00 | 11.94 | 191.00 | 4 Tackles, 5 Assists, 1 PD |
| LB | Devin White | TB | 10.00 | 10.06 | 161.00 | 4 Tackles, 3 Assists, 1 Fum Rcvy |
| CB | Carlton Davis | TB | DNP | 6.77 | 88.00 | Did Not Play |
| S | Jaquan Brisker | Chi | 8.00 | 8.64 | 121.00 | 6 Tackles, 2 Assists |
| Pos. | 1st Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Kirk Cousins | Min | 0(10.90) | 21.10 | 337.58 | 205 Pass, 37 Rush, 1 TD, 3 Int, 1 Fumb |
| RB | Samaje Perine | Cin | DNP | 8.03 | 120.40 | Did Not Play |
| WR | Brandon Aiyuk | SF | 0(22.20) | 11.37 | 181.90 | 16 Rush, 101 Receiving, 9 Rec, 1 TD |
| TE | Jordan Akins | Hou | 0(4.80) | 4.55 | 72.80 | 38 Receiving, 2 Rec |
| WR | Allen Lazard | GB | 0(8.40) | 9.48 | 132.70 | 59 Receiving, 5 Rec |
| DL | Lawrence Guy | NE | 3.00 | 4.15 | 54.00 | 3 Tackles |
| LB | Patrick Queen | Bal | 0(6.00) | 9.56 | 153.00 | 4 Tackles, 2 Assists |
| CB | Desmond King | Hou | 14.00 | 6.63 | 106.00 | 6 Tackles, 2 Assists, 1 Int, 1 PD |
| S | Jordan Poyer | Buf | DNP | 7.45 | 82.00 | Did Not Play |
| Pos. | 2nd Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Russell Wilson | Den | 0(26.58) | 16.44 | 230.14 | 222 Pass, 27 Rush, 3 TD, 1 Int, 1 Fumb |
| CB | Kenny Moore | Ind | DNP | 6.00 | 72.00 | Did Not Play |
| Offense = 134.00 Defense = 66 Total = 200.00 | ||||||
| Pos. | Bench | Proteam | TW | PPG | Total | Breakdown |
| WR | Tyler Lockett | Sea | 2.50 | 12.26 | 183.90 | 15 Receiving, 2 Rec |
| WR | Calvin Ridley | Jac | DNP | 0.00 | 0.00 | Did Not Play |
| DL | Aaron Donald | LAR | DNP | 7.00 | 77.00 | Did Not Play |
| DL | Jeffery Simmons | Ten | DNP | 6.43 | 90.00 | Did Not Play |
| LB | Devin Lloyd | Jac | 5.00 | 8.75 | 140.00 | 1 Tackle, 4 Assists |
| Pos. | Injured List | Proteam | TW | PPG | Total | Breakdown |
| TE | Zach Ertz | Ari | DNP | 9.21 | 92.10 | Did Not Play |