| Pos. | Starters | Proteam | TW | PPG | Total | Breakdown |
| QB | Baker Mayfield | TB | 6.18 | 19.59 | 333.06 | 137 Pass, 7 Rush |
| RB | Travis Etienne | Jac | 11.20 | 14.79 | 251.40 | 57 Rush, 30 Receiving, 5 Rec |
| RB | D'Andre Swift | Phi | DNP | 11.30 | 180.80 | Did Not Play |
| WR | DeAndre Hopkins | Ten | 14.10 | 10.95 | 186.10 | 46 Receiving, 7 Rec, 1 TD |
| WR | CeeDee Lamb | Dal | 29.00 | 19.86 | 337.70 | 7 Rush, 98 Receiving, 13 Rec, 2 TD |
| WR | K.J. Osborn | Min | 1.90 | 6.00 | 96.00 | 9 Receiving, 2 Rec |
| TE | George Kittle | SF | 0.00 | 10.04 | 170.70 | Played, No Stats |
| HB | Alec Pierce | Ind | 0.00 | 4.67 | 79.40 | Played, No Stats |
| PK | Jason Myers | Sea | 7.00 | 9.24 | 157.00 | 2 FG(<40), 1 XP |
| DL | DeForest Buckner | Ind | 10.00 | 7.88 | 134.00 | 1 Tackle, 5 Assists, 1.0 Sack |
| DL | Aaron Donald | LAR | DNP | 5.44 | 87.00 | Did Not Play |
| DL | Andrew Van Ginkel | Mia | 1.00 | 6.76 | 115.00 | 1 Tackle |
| LB | Dre Greenlaw | SF | 0.00 | 8.19 | 131.00 | Played, No Stats |
| LB | Frankie Luvu | Car | 9.00 | 9.53 | 162.00 | 3 Tackles, 3 Assists, 1 FF |
| LB | Alex Singleton | Den | 13.00 | 11.47 | 195.00 | 5 Tackles, 8 Assists |
| CB | Kenny Moore | Ind | 2.00 | 8.25 | 132.00 | 2 Tackles |
| S | Jessie Bates | Atl | 4.00 | 11.06 | 188.00 | 4 Tackles |
| Pos. | 1st Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Lamar Jackson | Bal | 0 | 22.66 | 385.22 | Played, No Stats |
| RB | Rico Dowdle | Dal | 11.50 | 5.19 | 83.00 | 46 Rush, 54 Receiving, 3 Rec |
| WR | Josh Reynolds | Det | 0(6.90) | 6.46 | 109.80 | 44 Receiving, 5 Rec |
| TE | Tyler Higbee | LAR | DNP | 5.67 | 85.00 | Did Not Play |
| WR | Jonathan Mingo | Car | DNP | 4.22 | 63.30 | Did Not Play |
| PK | Evan McPherson | Cin | 0(8.00) | 8.24 | 140.00 | 1 FG(40-49), 4 XP |
| DL | Ed Oliver | Buf | 1.00 | 6.06 | 97.00 | 1 Tackle |
| LB | Pete Werner | NO | 0(4.00) | 6.75 | 108.00 | 2 Tackles, 2 Assists |
| CB | Charvarius Ward | SF | 0(4.00) | 7.59 | 129.00 | 4 Tackles |
| S | Kamren Curl | Was | DNP | 8.19 | 131.00 | Did Not Play |
| Pos. | 2nd Backup | Proteam | TW | PPG | Total | Breakdown |
| WR | Robert Woods | Hou | DNP | 4.95 | 69.30 | Did Not Play |
| WR | Marvin Mims | Den | 0(2.20) | 4.23 | 67.70 | 1 Rush, 16 Receiving, 1 Rec |
| Offense = 80.88 Defense = 39 Total = 119.88 | ||||||
| Pos. | Bench | Proteam | TW | PPG | Total | Breakdown |
| WR | Keenan Allen | LAC | DNP | 17.51 | 227.66 | Did Not Play |
| WR | Marquise Brown | Ari | DNP | 7.80 | 109.20 | Did Not Play |
| WR | DeVante Parker | NE | 1.10 | 4.30 | 55.90 | 6 Receiving, 1 Rec |
| DL | Vita Vea | TB | 1.00 | 4.53 | 68.00 | 1 Tackle |
| Pos. | Injured List | Proteam | TW | PPG | Total | Breakdown |
| WR | Mike Williams | LAC | DNP | 13.57 | 40.70 | Did Not Play |