| Pos. | Starters | Proteam | TW | PPG | Total | Breakdown |
| QB | Baker Mayfield | TB | 6.18 | 19.59 | 333.06 | 137 Pass, 7 Rush |
| RB | Najee Harris | Pit | 21.80 | 10.71 | 182.00 | 112 Rush, 21 Receiving, 5 Rec, 1 TD |
| RB | Jonathan Taylor | Ind | 26.60 | 14.69 | 146.90 | 188 Rush, 8 Receiving, 2 Rec, 1 TD |
| WR | CeeDee Lamb | Dal | 29.00 | 19.86 | 337.70 | 7 Rush, 98 Receiving, 13 Rec, 2 TD |
| WR | D.K. Metcalf | Sea | 1.50 | 12.02 | 192.40 | 10 Receiving, 1 Rec |
| WR | Amon-Ra St. Brown | Det | 23.90 | 17.02 | 272.40 | 144 Receiving, 7 Rec, 1 TD |
| TE | Cole Kmet | Chi | 5.60 | 8.51 | 144.60 | 41 Receiving, 3 Rec |
| HB | Aaron Jones | GB | 16.60 | 10.99 | 120.90 | 111 Rush, 30 Receiving, 5 Rec |
| PK | Greg Joseph | Min | 9.00 | 6.88 | 117.00 | 1 FG(<40), 1 FG(40-49), 2 XP |
| DL | Josh Allen | Jac | 9.00 | 8.76 | 149.00 | 2 Tackles, 3 Assists, 1.0 Sack |
| DL | Kwity Paye | Ind | 2.00 | 6.13 | 98.00 | 1 Tackle, 1 Assist |
| DL | Quinnen Williams | NYJ | 11.00 | 5.82 | 99.00 | 2 Tackles, 1 Assist, 2.0 Sacks |
| LB | Cody Barton | Was | 8.00 | 9.85 | 128.00 | 4 Tackles, 4 Assists |
| LB | Divine Deablo | LV | 10.00 | 7.67 | 115.00 | 6 Tackles, 4 Assists |
| LB | Quincy Williams | NYJ | 8.00 | 9.94 | 169.00 | 4 Tackles, 4 Assists |
| CB | Mike Hilton | Cin | 4.00 | 6.65 | 113.00 | 3 Tackles, 1 PD |
| S | Antoine Winfield | TB | 12.00 | 11.76 | 200.00 | 4 Tackles, 1 Assist, 1.0 Sack, 1 FF |
| Pos. | 1st Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Derek Carr | NO | 0(35.16) | 17.30 | 294.12 | 264 Pass, 6 Rush, 4 TD |
| WR | Justin Watson | KC | 0 | 4.50 | 76.50 | Played, No Stats |
| TE | George Kittle | SF | 0 | 10.04 | 170.70 | Played, No Stats |
| RB | Ronnie Rivers | LAR | 0(5.20) | 1.96 | 17.60 | 52 Rush |
| LB | Devin White | TB | 0(3.00) | 7.86 | 110.00 | 3 Tackles |
| S | Xavier McKinney | NYG | 0(19.00) | 8.94 | 152.00 | 2 Tackles, 4 Assists, 2 Int, 3 PD |
| Pos. | 2nd Backup | Proteam | TW | PPG | Total | Breakdown |
| WR | DeVante Parker | NE | 0(1.10) | 4.30 | 55.90 | 6 Receiving, 1 Rec |
| RB | Tyjae Spears | Ten | 0(20.10) | 7.52 | 127.80 | 25 Rush, 41 Receiving, 3 Rec, 2 TD |
| LB | Jahlani Tavai | NE | 0(6.00) | 7.76 | 132.00 | 6 Tackles |
| Offense = 140.18 Defense = 64 Total = 204.18 | ||||||
| Pos. | Bench | Proteam | TW | PPG | Total | Breakdown |
| RB | Chase Brown | Cin | 5.80 | 3.88 | 46.50 | 43 Rush, 10 Receiving, 1 Rec |
| RB | Zach Charbonnet | Sea | 7.00 | 5.60 | 89.60 | 32 Rush, 28 Receiving, 2 Rec |
| RB | D'Onta Foreman | Chi | DNP | 9.52 | 85.70 | Did Not Play |
| RB | Isiah Pacheco | KC | 0.00 | 12.86 | 192.90 | Played, No Stats |
| RB | Kyren Williams | LAR | DNP | 20.08 | 241.00 | Did Not Play |
| WR | Marquise Brown | Ari | DNP | 7.80 | 109.20 | Did Not Play |
| DL | Jonathan Greenard | Hou | DNP | 0.00 | 0.00 | Did Not Play |
| Pos. | Injured List | Proteam | TW | PPG | Total | Breakdown |
| QB | Joe Burrow | Cin | DNP | 17.82 | 178.16 | Did Not Play |