| Pos. | Starters | Proteam | TW | PPG | Total | Breakdown |
| QB | Justin Fields | Chi | 26.72 | 21.36 | 192.20 | 223 Pass, 58 Rush, 2 TD |
| RB | Raheem Mostert | Mia | 22.50 | 17.49 | 227.40 | 96 Rush, 4 Receiving, 1 Rec, 2 TD |
| RB | Saquon Barkley | NYG | 22.60 | 15.21 | 152.10 | 86 Rush, 15 Receiving, 3 Rec, 2 TD, 1 Fumb |
| WR | Jaylen Waddle | Mia | 10.90 | 11.06 | 132.70 | 79 Receiving, 6 Rec |
| WR | Michael Pittman | Ind | 13.50 | 13.07 | 169.90 | 95 Receiving, 8 Rec |
| WR | Chris Olave | NO | 10.80 | 11.68 | 151.80 | 28 Receiving, 4 Rec, 1 TD |
| TE | Jonnu Smith | Atl | 4.70 | 5.96 | 77.50 | 27 Receiving, 4 Rec |
| HB | Kareem Hunt | Cle | 9.50 | 8.16 | 89.80 | 27 Rush, 3 Receiving, 1 Rec, 1 TD |
| PK | Chase McLaughlin | TB | 11.00 | 7.62 | 99.00 | 1 FG(<40), 1 FG(50-59), 3 XP |
| DL | Justin Madubuike | Bal | 11.00 | 7.00 | 91.00 | 5 Tackles, 2 Assists, 1.0 Sack |
| DL | Harrison Phillips | Min | 8.00 | 6.31 | 82.00 | 3 Tackles, 1 Assist, 1.0 Sack |
| DL | Denico Autry | Ten | 2.00 | 6.38 | 83.00 | 2 Tackles |
| LB | Alex Singleton | Den | 19.00 | 11.77 | 153.00 | 10 Tackles, 4 Assists, 1.0 Sack, 1 PD |
| LB | Jerome Baker | Mia | 0.00 | 7.15 | 93.00 | Played, No Stats |
| LB | Zaire Franklin | Ind | 14.00 | 13.33 | 160.00 | 6 Tackles, 8 Assists |
| CB | Darious Williams | Jac | 10.00 | 7.00 | 91.00 | 2 Tackles, 1 Int, 3 PD |
| S | Reed Blankenship | Phi | 3.00 | 9.64 | 106.00 | 3 Tackles |
| Pos. | 1st Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Bryce Young | Car | 0(8.48) | 11.90 | 142.78 | 137 Pass, 40 Rush, 1 Fumb |
| RB | Dameon Pierce | Hou | 0(1.20) | 6.52 | 65.20 | 9 Rush, -2 Receiving, 1 Rec |
| WR | Rondale Moore | Ari | DNP | 5.24 | 68.10 | Team had a Bye |
| TE | Gerald Everett | LAC | 0(6.40) | 5.88 | 64.70 | 39 Receiving, 5 Rec |
| WR | Donovan Peoples-Jones | Det | 0(2.20) | 1.59 | 15.90 | 17 Receiving, 1 Rec |
| PK | Ka'imi Fairbairn | Hou | DNP | 8.00 | 72.00 | Did Not Play |
| DL | Vita Vea | TB | DNP | 5.27 | 58.00 | Did Not Play |
| LB | Denzel Perryman | Hou | 0(6.00) | 7.13 | 57.00 | 1 Tackle, 3 Assists, 2 PD |
| CB | Deommodore Lenoir | SF | 0(5.00) | 6.38 | 83.00 | 2 Tackles, 1 Assist, 2 PD |
| S | Jabrill Peppers | NE | 0(9.00) | 7.38 | 96.00 | 1 Tackle, 2 Assists, 1 Int, 1 PD |
| Pos. | 2nd Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Deshaun Watson | Cle | DNP | 17.13 | 102.80 | Did Not Play |
| WR | Khalil Shakir | Buf | 0(1.70) | 5.17 | 67.20 | 12 Receiving, 1 Rec |
| WR | Josh Reynolds | Det | 0(11.90) | 7.22 | 93.90 | 44 Receiving, 3 Rec, 1 TD |
| DL | Chris Jones | KC | 0 | 4.75 | 57.00 | Played, No Stats |
| Offense = 132.22 Defense = 67 Total = 199.22 | ||||||
| Pos. | Bench | Proteam | TW | PPG | Total | Breakdown |
| DL | Matt Judon | NE | DNP | 7.50 | 30.00 | Did Not Play |
| DL | Zaven Collins | Ari | DNP | 4.31 | 56.00 | Team had a Bye |