| Pos. | Starters | Proteam | TW | PPG | Total | Breakdown |
| QB | Justin Herbert | LAC | 1.84 | 21.13 | 274.72 | 96 Pass, 1 Int |
| RB | Kenneth Walker | Sea | 7.40 | 12.41 | 136.50 | 21 Rush, 33 Receiving, 4 Rec |
| RB | Joe Mixon | Cin | 20.00 | 13.73 | 178.50 | 79 Rush, 46 Receiving, 3 Rec, 1 TD |
| WR | Brandin Cooks | Dal | 4.70 | 8.93 | 107.20 | 37 Receiving, 2 Rec |
| WR | Deebo Samuel | SF | 30.50 | 15.14 | 166.50 | 1 Rush, 149 Receiving, 7 Rec, 2 TD |
| WR | Tee Higgins | Cin | 8.20 | 7.96 | 71.60 | 72 Receiving, 2 Rec |
| TE | David Njoku | Cle | 24.10 | 8.65 | 112.50 | 91 Receiving, 6 Rec, 2 TD |
| HB | Gus Edwards | Bal | 1.50 | 10.81 | 140.50 | 15 Rush |
| PK | Blake Grupe | NO | 3.00 | 8.77 | 114.00 | 4 XP, 1 Miss(<40) |
| DL | Trey Hendrickson | Cin | 11.00 | 7.46 | 97.00 | 2 Tackles, 2.0 Sacks, 1 PD |
| DL | Zach Allen | Den | 5.00 | 5.62 | 73.00 | 1 Tackle, 1.0 Sack |
| DL | Shaquil Barrett | TB | 4.00 | 6.23 | 81.00 | 2 Tackles, 2 Assists |
| LB | Germaine Pratt | Cin | 12.00 | 9.62 | 125.00 | 4 Tackles, 6 Assists, 0.5 Sack |
| LB | Micah McFadden | NYG | 7.00 | 8.33 | 100.00 | 2 Tackles, 3 Assists, 0.5 Sack |
| LB | Bobby Okereke | NYG | 6.00 | 11.46 | 149.00 | 5 Tackles, 1 Assist |
| CB | Rasul Douglas | Buf | 4.00 | 7.25 | 87.00 | 3 Assists, 1 PD |
| S | Julian Love | Sea | 16.00 | 8.62 | 112.00 | 5 Tackles, 2 Assists, 1 Int, 1 FF, 1 PD |
| Pos. | 1st Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Matthew Stafford | LAR | 0(29.66) | 19.11 | 229.28 | 294 Pass, -1 Rush, 3 TD |
| RB | Dalvin Cook | NYJ | 0(1.30) | 2.55 | 33.20 | 13 Rush, -5 Receiving, 1 Rec |
| WR | Jonathan Mingo | Car | 0(3.20) | 4.64 | 55.70 | 22 Receiving, 2 Rec |
| TE | Michael Mayer | LV | 0(1.90) | 3.54 | 46.00 | 14 Receiving, 1 Rec |
| WR | Chris Godwin | TB | 0(7.80) | 8.63 | 112.20 | 53 Receiving, 5 Rec |
| PK | Riley Patterson | Det | 0 | 6.23 | 81.00 | 1 XP, 1 Miss(<40) |
| DL | Jeffery Simmons | Ten | DNP | 6.33 | 76.00 | Did Not Play |
| LB | Lavonte David | TB | 0(7.00) | 10.45 | 115.00 | 4 Tackles, 2 Assists, 1 PD |
| CB | Roger McCreary | Ten | 0(8.00) | 6.91 | 76.00 | 5 Tackles, 2 Assists, 1 PD |
| S | Harrison Smith | Min | 0(2.00) | 7.46 | 97.00 | 1 Tackle, 1 Assist |
| Pos. | 2nd Backup | Proteam | TW | PPG | Total | Breakdown |
| WR | Tank Dell | Hou | DNP | 12.86 | 141.50 | Did Not Play |
| Offense = 101.24 Defense = 65 Total = 166.24 | ||||||
| Pos. | Bench | Proteam | TW | PPG | Total | Breakdown |
| RB | James Conner | Ari | DNP | 10.86 | 97.70 | Team had a Bye |
| RB | Chase Edmonds | TB | 6.80 | 1.99 | 17.90 | 40 Rush, 18 Receiving, 2 Rec |
| WR | Terry McLaurin | Was | DNP | 9.03 | 117.40 | Team had a Bye |
| WR | Michael Wilson | Ari | DNP | 7.72 | 69.50 | Team had a Bye |
| LB | Pete Werner | NO | 5.00 | 7.00 | 84.00 | 2 Tackles, 1 Fum Rcvy |
| Pos. | Injured List | Proteam | TW | PPG | Total | Breakdown |
| TE | Dawson Knox | Buf | 5.10 | 3.85 | 30.80 | 2 Tackles, 1 Fum Rcvy |