| Pos. | Starters | Proteam | TW | PPG | Total | Breakdown |
| QB | Jared Goff | Det | 12.84 | 20.58 | 329.30 | 271 Pass, 1 TD, 2 Int |
| RB | Rachaad White | TB | 7.60 | 14.16 | 226.60 | 42 Rush, 24 Receiving, 4 Rec, 1 Fumb |
| RB | Zamir White | LV | 13.10 | 3.65 | 54.80 | 71 Rush, 35 Receiving, 5 Rec |
| WR | Brandon Aiyuk | SF | 20.90 | 13.91 | 208.70 | 114 Receiving, 7 Rec, 1 TD |
| WR | Tyreek Hill | Mia | 10.60 | 20.01 | 300.20 | 76 Receiving, 6 Rec |
| WR | D.J. Moore | Chi | 26.40 | 14.44 | 231.10 | 159 Receiving, 9 Rec, 1 TD |
| TE | Jake Ferguson | Dal | 5.30 | 8.23 | 131.70 | 33 Receiving, 4 Rec |
| HB | Jahmyr Gibbs | Det | 4.80 | 14.86 | 208.10 | 43 Rush, 1 Rec |
| PK | Jason Myers | Sea | 13.00 | 9.38 | 150.00 | 1 FG(<40), 2 FG(40-49), 2 XP |
| DL | Bradley Chubb | Mia | 6.00 | 8.81 | 141.00 | 3 Tackles, 3 Assists |
| DL | Carl Granderson | NO | 1.00 | 7.25 | 116.00 | 1 Assist |
| DL | Montez Sweat | Chi | 1.00 | 7.25 | 116.00 | 1 Assist |
| LB | Bobby Okereke | NYG | 16.00 | 11.19 | 179.00 | 2 Tackles, 8 Assists, 1.5 Sacks |
| LB | Patrick Queen | Bal | 7.00 | 9.63 | 154.00 | 3 Tackles, 3 Assists, 1 PD |
| LB | Fred Warner | SF | 6.00 | 11.75 | 188.00 | 2 Tackles, 4 Assists |
| CB | Nate Hobbs | LV | 8.00 | 8.58 | 103.00 | 4 Tackles, 4 Assists |
| S | Antoine Winfield | TB | 7.00 | 11.75 | 188.00 | 5 Tackles, 2 Assists |
| Pos. | 1st Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Tyrod Taylor | NYG | 0(20.76) | 7.06 | 77.66 | 319 Pass, 40 Rush, 1 TD, 1 Int |
| RB | Brian Robinson | Was | 0(9.60) | 12.14 | 170.00 | 44 Rush, 32 Receiving, 4 Rec |
| WR | Drake London | Atl | 0(7.60) | 8.92 | 133.78 | 56 Receiving, 4 Rec |
| TE | Noah Gray | KC | 0(3.20) | 3.54 | 56.60 | 17 Receiving, 3 Rec |
| WR | Michael Pittman | Ind | 0(7.10) | 12.45 | 186.80 | 46 Receiving, 5 Rec |
| PK | Wil Lutz | Den | 0(11.00) | 7.75 | 124.00 | 2 FG(<40), 1 FG(40-49), 1 XP |
| DL | Zach Sieler | Mia | 0(12.00) | 7.44 | 119.00 | 3 Tackles, 2 Assists, 1.0 Sack, 1 FF |
| LB | Frankie Luvu | Car | 0(5.00) | 9.56 | 153.00 | 1 Tackle, 4 Assists |
| CB | Rudy Ford | GB | 0(1.00) | 6.92 | 90.00 | 1 Tackle |
| S | Kyle Hamilton | Bal | DNP | 0.00 | 0.00 | Did Not Play |
| Pos. | 2nd Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Desmond Ridder | Atl | 0(-1.32) | 12.47 | 187.00 | 17 Pass, 1 Int |
| RB | Josh Jacobs | LV | DNP | 12.58 | 163.60 | Did Not Play |
| WR | Brandin Cooks | Dal | 0(14.50) | 8.87 | 133.00 | 60 Receiving, 5 Rec, 1 TD |
| DL | Sam Hubbard | Cin | 0(8.00) | 6.00 | 84.00 | 3 Tackles, 2 Assists, 1 Fum Rcvy |
| LB | Samson Ebukam | Ind | 0(3.00) | 6.31 | 101.00 | 1 Tackle, 2 Assists |
| Offense = 114.54 Defense = 52 Total = 166.54 | ||||||
| Pos. | Bench | Proteam | TW | PPG | Total | Breakdown |
| TE | Tucker Kraft | GB | 7.80 | 3.65 | 58.40 | 48 Receiving, 6 Rec |
| Pos. | Injured List | Proteam | TW | PPG | Total | Breakdown |
| WR | Mike Williams | LAC | DNP | 13.57 | 40.70 | Did Not Play |