| Pos. | Starters | Proteam | TW | PPG | Total | Breakdown |
| QB | Sam Howell | Was | 10.28 | 20.37 | 285.18 | 102 Pass, 22 Rush, 1 TD, 1 Int |
| RB | Breece Hall | NYJ | 2.30 | 11.74 | 164.30 | 12 Rush, 6 Receiving, 1 Rec |
| RB | Rachaad White | TB | 20.90 | 14.45 | 202.30 | 89 Rush, 50 Receiving, 2 Rec, 1 TD |
| WR | Tyler Lockett | Sea | 3.60 | 0.00 | 0.00 | |
| WR | George Pickens | Pit | 6.20 | 9.06 | 126.90 | 47 Receiving, 3 Rec |
| WR | Courtland Sutton | Den | 9.60 | 11.64 | 163.00 | 71 Receiving, 5 Rec |
| TE | T.J. Hockenson | Min | 9.30 | 11.76 | 164.70 | 63 Receiving, 6 Rec |
| HB | Alvin Kamara | NO | 13.50 | 16.69 | 183.60 | 66 Rush, 44 Receiving, 5 Rec |
| PK | Jake Moody | SF | 10.00 | 8.14 | 114.00 | 1 FG(40-49), 6 XP |
| DL | Shaquil Barrett | TB | 7.00 | 6.29 | 88.00 | 2 Assists, 0.5 Sack, 1 FF |
| DL | Maxx Crosby | LV | 4.00 | 10.14 | 142.00 | 2 Tackles, 2 Assists |
| DL | Micah Parsons | Dal | 2.00 | 7.43 | 104.00 | 2 Assists |
| LB | De'Vondre Campbell | GB | 5.00 | 7.10 | 71.00 | 5 Tackles |
| LB | Eric Kendricks | LAC | 17.00 | 9.33 | 112.00 | 9 Tackles, 3 Assists, 1.0 Sack, 1 PD |
| LB | Bobby Wagner | Sea | 11.00 | 0.00 | 0.00 | |
| CB | Jerry Jacobs | Det | 0.00 | 6.00 | 78.00 | Played, No Stats |
| S | Josh Metellus | Min | 9.00 | 9.00 | 126.00 | 5 Tackles, 1.0 Sack |
| Pos. | 1st Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Kyler Murray | Ari | 0(15.34) | 18.50 | 92.50 | 211 Pass, 49 Rush, 1 TD, 2 Int |
| RB | Kenneth Gainwell | Phi | 0(2.10) | 0.00 | 0.00 | |
| WR | Tyler Boyd | Cin | 0(6.30) | 7.01 | 98.10 | 53 Receiving, 2 Rec |
| TE | Cole Kmet | Chi | 0(10.80) | 9.02 | 126.30 | 23 Receiving, 5 Rec, 1 TD |
| DL | Jordan Davis | Phi | 0(2.00) | 0.00 | 0.00 | |
| LB | Jack Campbell | Det | 0(5.00) | 5.71 | 80.00 | 1 Tackle, 4 Assists |
| CB | Brandon Stephens | Bal | 0(4.00) | 5.93 | 83.00 | 3 Tackles, 1 Assist |
| S | Jordan Poyer | Buf | 0(7.00) | 7.00 | 91.00 | 4 Tackles, 2 Assists, 1 PD |
| Pos. | 2nd Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Joe Burrow | Cin | DNP | 17.82 | 178.16 | Did Not Play |
| RB | Isiah Pacheco | KC | DNP | 13.11 | 157.30 | Did Not Play |
| LB | Drue Tranquill | KC | 0(6.00) | 7.54 | 98.00 | 1 Tackle, 1 Assist, 1.0 Sack |
| S | Jevon Holland | Mia | DNP | 9.10 | 91.00 | Did Not Play |
| Offense = 85.68 Defense = 55 Total = 140.68 | ||||||
| Pos. | Bench | Proteam | TW | PPG | Total | Breakdown |
| RB | Joshua Kelley | LAC | 2.30 | 4.19 | 58.60 | 22 Rush, 6 Receiving, 1 Rec, 1 Fumb |
| DL | Jaelan Phillips | Mia | DNP | 9.50 | 76.00 | Did Not Play |
| LB | Jamin Davis | Was | DNP | 8.92 | 116.00 | Did Not Play |
| LB | Tyrel Dodson | Buf | 10.00 | 5.50 | 77.00 | 4 Tackles, 4 Assists, 0.5 Sack |