| Pos. | Starters | Proteam | TW | PPG | Total | Breakdown |
| QB | Trevor Lawrence | Jac | 18.66 | 19.93 | 279.00 | 264 Pass, 41 Rush, 1 TD, 2 Fumb |
| RB | Austin Ekeler | LAC | 5.80 | 12.81 | 140.90 | 9 Rush, 29 Receiving, 4 Rec |
| RB | Javonte Williams | Den | 3.00 | 9.38 | 122.00 | 27 Rush, -7 Receiving, 2 Rec |
| WR | D.K. Metcalf | Sea | 10.30 | 0.00 | 0.00 | |
| WR | Puka Nacua | LAR | 7.80 | 13.51 | 189.20 | 3 Rush, 50 Receiving, 5 Rec |
| WR | Deebo Samuel | SF | 19.90 | 15.53 | 186.40 | 11 Rush, 48 Receiving, 4 Rec, 2 TD |
| TE | George Kittle | SF | 6.40 | 10.73 | 150.20 | 54 Receiving, 2 Rec |
| HB | Justin Jefferson | Min | 11.90 | 15.39 | 107.70 | 84 Receiving, 7 Rec |
| PK | Jake Moody | SF | 10.00 | 8.14 | 114.00 | 1 FG(40-49), 6 XP |
| DL | Josh Allen | Jac | 4.00 | 8.64 | 121.00 | 2 Tackles, 2 Assists |
| DL | Michael Hoecht | LAR | 4.00 | 6.29 | 88.00 | 3 Tackles, 1 PD |
| DL | Quinnen Williams | NYJ | 5.00 | 5.93 | 83.00 | 2 Tackles, 1 Assist, 0.5 Sack |
| LB | Tremaine Edmunds | Chi | 21.00 | 11.08 | 133.00 | 5 Tackles, 4 Assists, 1 Int, 1 TD, 1 PD |
| LB | Micah McFadden | NYG | 6.00 | 8.15 | 106.00 | 5 Tackles, 1 Assist |
| LB | Jahlani Tavai | NE | 9.00 | 7.79 | 109.00 | 2 Tackles, 1 Assist, 1 Int, 1 PD |
| CB | Roger McCreary | Ten | 8.00 | 7.00 | 84.00 | 7 Tackles, 1 PD |
| S | Antoine Winfield | TB | 13.00 | 12.00 | 168.00 | 8 Tackles, 2 Assists, 1 FF |
| Pos. | 1st Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Tommy DeVito | NYG | 0(10.68) | 11.92 | 107.28 | 177 Pass, 36 Rush |
| WR | Jameson Williams | Det | 0(6.70) | 5.30 | 53.00 | 47 Receiving, 4 Rec |
| TE | Dalton Kincaid | Buf | 0 | 7.00 | 91.00 | Played, No Stats |
| RB | Zamir White | LV | 0(16.00) | 2.09 | 27.20 | 69 Rush, 16 Receiving, 3 Rec, 1 TD |
| S | Kyle Hamilton | Bal | 0(8.00) | 8.36 | 117.00 | 6 Tackles, 1 Assist, 1 PD |
| Pos. | 2nd Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Aidan O'Connell | LV | 0(33.92) | 12.95 | 103.62 | 248 Pass, 4 TD |
| Offense = 93.76 Defense = 70 Total = 163.76 | ||||||
| Pos. | Bench | Proteam | TW | PPG | Total | Breakdown |
| RB | Chase Brown | Cin | 6.60 | 3.72 | 33.50 | 23 Rush, 28 Receiving, 3 Rec |
| RB | Rico Dowdle | Dal | 2.20 | 5.08 | 71.10 | 4 Rush, 8 Receiving, 2 Rec |
| RB | Jerome Ford | Cle | 5.10 | 10.72 | 150.10 | 20 Rush, 11 Receiving, 4 Rec |
| RB | Kareem Hunt | Cle | 2.50 | 7.69 | 92.30 | 8 Rush, 12 Receiving, 1 Rec |
| RB | Joshua Kelley | LAC | 2.30 | 4.19 | 58.60 | 22 Rush, 6 Receiving, 1 Rec, 1 Fumb |
| RB | Jonathan Taylor | Ind | DNP | 13.30 | 93.10 | Did Not Play |
| RB | Jeff Wilson | Mia | 1.10 | 3.13 | 21.90 | 5 Rush, 1 Receiving, 1 Rec |
| WR | Elijah Moore | Cle | 2.70 | 6.22 | 87.10 | 17 Receiving, 2 Rec |
| WR | Parker Washington | Jac | 3.20 | 1.98 | 11.90 | 12 Receiving, 4 Rec |
| DL | A.J. Epenesa | Buf | DNP | 5.77 | 75.00 | Did Not Play |
| Pos. | Injured List | Proteam | TW | PPG | Total | Breakdown |
| LB | Jordan Hicks | Min | DNP | 11.50 | 115.00 | Did Not Play |