| Position | Starters | Proteam | TW | PPG | Total | Breakdown |
|---|---|---|---|---|---|---|
| QB | Davis Mills | Hou | 33.24 | 0.00 | 0 | |
| RB | Saquon Barkley | NYG | 6.4 | 0.00 | 0 | |
| RB | Jonathan Taylor | Ind | 11.0 | 0.00 | 0 | |
| WR | D.K. Metcalf | Sea | 8.3 | 0.00 | 0 | |
| WR | Deebo Samuel | SF | 28.96 | 0.00 | 0 | |
| WR | Mike Williams | LAC | 22.4 | 0.00 | 0 | |
| TE | George Kittle | SF | 3.5 | 0.00 | 0 | |
| HB (RB) | Austin Ekeler | LAC | 26.4 | 0.00 | 0 | |
| PK | Robbie Gould | SF | 10.0 | 0.00 | 0 | |
| DL | Dorance Armstrong | Dal | 6.0 | 5.23 | 68.00 | 3 Assists, 0.5 Sack, 1 PD |
| DL | Myles Garrett | Cle | 5.0 | 7.71 | 131.00 | 1 Tackle, 1.0 Sack |
| DL | Cameron Jordan | NO | 8.0 | 7.50 | 120.00 | 1 Tackle, 1 Assist, 1.0 Sack, 2 PD |
| LB | Anthony Barr | Min | 19.0 | 9.82 | 108.00 | 6 Tackles, 5 Assists, 2.0 Sacks |
| LB | Jordyn Brooks | Sea | 20.0 | 0.00 | 0 | |
| LB | Shaq Thompson | Car | 6.0 | 0.00 | 0 | |
| CB | Kendall Fuller | Was | 4.0 | 0.00 | 0 | |
| S | Xavier Woods | Car | 7.0 | 0.00 | 0 | |
| Position | 1st Backups | Proteam | TW | PPG | Total | Breakdown |
| QB | Taylor Heinicke | Was | 0(5.1) | 0.00 | 0 | |
| RB | Devonta Freeman | Bal | 0(3.7) | 0.00 | 0 | |
| WR | Odell Beckham | LAR | 0(2.8) | 0.00 | 0 | |
| TE | Brevin Jordan | Hou | DNP | 5.72 | 45.80 | Did Not Play |
| HB (RB) | Jaret Patterson | Was | 0(4.5) | 0.00 | 0 | |
| DL | Larry Ogunjobi | Cle | DNP | 4.81 | 77.00 | Did Not Play |
| LB | Patrick Queen | Bal | 0(3.0) | 0.00 | 0 | |
| CB | James Bradberry | NYG | DNP | 5.69 | 91.00 | Did Not Play |
| S | Jalen Thompson | Ari | 0(13.0) | 0.00 | 0 | |
| Position | 2nd Backups | Proteam | TW | PPG | Total | Breakdown |
| WR | Van Jefferson | LAR | 0(4.1) | 0.00 | 0 | |
| HB (WR) | Rashod Bateman | Bal | 0(3.2) | 0.00 | 0 | |
| LB | Cory Littleton | Car | 0(1.0) | 0.00 | 0 | |
| Offense = 150.2 Defense = 75 Total = 225.2 | ||||||
| Position | Bench | Proteam | TW | PPG | Total | Breakdown |
| QB | Joe Burrow | Cin | DNP | 24.01 | 384.24 | Did Not Play |
| QB | Deshaun Watson | Hou | DNP | 0.00 | 0 | Did Not Play |
| RB | Boston Scott | Phi | 0(0.0) | 5.48 | 93.10 | Played, No Stats |
| WR | Josh Palmer | LAC | 0(12.5) | 0.00 | 0 | |