| Pos. | Starters | Proteam | TW | PPG | Total | Breakdown |
| QB | Tyrod Taylor | NYG | 20.76 | 7.06 | 77.66 | 319 Pass, 40 Rush, 1 TD, 1 Int |
| RB | Jerome Ford | Cle | 25.10 | 11.50 | 184.00 | 64 Rush, 57 Receiving, 2 Rec, 2 TD |
| RB | Kenneth Walker | Sea | 15.00 | 12.59 | 176.30 | 53 Rush, 22 Receiving, 3 Rec, 1 TD |
| WR | Nico Collins | Hou | 12.20 | 13.46 | 188.40 | 7 Rush, 80 Receiving, 7 Rec |
| WR | DeAndre Hopkins | Ten | 10.70 | 10.75 | 172.00 | 72 Receiving, 7 Rec |
| WR | Terry McLaurin | Was | 14.10 | 10.07 | 161.10 | 61 Receiving, 4 Rec, 1 TD |
| TE | Jake Ferguson | Dal | 5.30 | 8.23 | 131.70 | 33 Receiving, 4 Rec |
| HB | Isiah Pacheco | KC | 26.00 | 13.78 | 192.90 | 130 Rush, 35 Receiving, 7 Rec, 1 TD |
| PK | Brandon Aubrey | Dal | 11.00 | 10.56 | 169.00 | 1 FG(40-49), 1 FG(50-59), 2 XP |
| DL | Nick Bosa | SF | 4.00 | 6.50 | 104.00 | 2 Tackles, 1 Assist, 1 PD |
| DL | Danielle Hunter | Min | 3.00 | 9.56 | 153.00 | 1 Tackle, 2 Assists |
| DL | Montez Sweat | Chi | 1.00 | 7.25 | 116.00 | 1 Assist |
| LB | Cody Barton | Was | 12.00 | 10.00 | 120.00 | 9 Tackles, 3 Assists |
| LB | Nate Landman | Atl | 6.00 | 8.20 | 123.00 | 5 Tackles, 1 Assist |
| LB | Robert Spillane | LV | 6.00 | 10.94 | 175.00 | 5 Tackles, 1 Assist |
| CB | Jason Pinnock | NYG | 2.00 | 7.56 | 121.00 | 2 Assists |
| S | P.J. Locke | Den | 7.00 | 7.00 | 77.00 | 5 Tackles, 1 Assist, 1 PD |
| Pos. | 1st Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Joe Flacco | Cle | 0(28.66) | 18.26 | 127.84 | 309 Pass, 3 Rush, 3 TD, 1 Int |
| RB | Justice Hill | Bal | 0(19.70) | 6.15 | 92.20 | 48 Rush, 64 Receiving, 5 Rec, 1 TD |
| WR | DeVante Parker | NE | 0(2.00) | 4.57 | 54.80 | 15 Receiving, 1 Rec |
| TE | Taysom Hill | NO | 0(10.54) | 8.01 | 120.12 | 11 Pass, 1 Rush, 30 Receiving, 2 Rec, 1 TD |
| WR | Jordan Addison | Min | 0(4.30) | 10.79 | 172.60 | 28 Receiving, 3 Rec |
| LB | Kaden Elliss | Atl | 0(13.00) | 8.63 | 138.00 | 6 Tackles, 3 Assists, 1.0 Sack |
| S | Kamren Curl | Was | 0(9.00) | 8.19 | 131.00 | 6 Tackles, 3 Assists |
| Pos. | 2nd Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Taylor Heinicke | Atl | 0(17.12) | 12.67 | 76.00 | 163 Pass, 46 Rush, 2 TD, 3 Int |
| RB | Isaiah Spiller | LAC | 0(1.90) | 1.78 | 16.00 | -1 Rush, 10 Receiving, 2 Rec |
| RB | D'Ernest Johnson | Jac | 0 | 1.87 | 29.90 | Played, No Stats |
| DL | Jonathan Greenard | Hou | DNP | 0.00 | 0.00 | Did Not Play |
| LB | David Long | Mia | 0(7.00) | 6.88 | 110.00 | 5 Tackles, 2 Assists |
| Offense = 140.16 Defense = 41 Total = 181.16 | ||||||
| Pos. | Bench | Proteam | TW | PPG | Total | Breakdown |
| RB | Rashaad Penny | Phi | 0.00 | 0.90 | 2.70 | Played, No Stats |
| WR | Amari Cooper | Cle | DNP | 0.00 | 0.00 | Did Not Play |
| WR | Jaylen Waddle | Mia | DNP | 0.00 | 0.00 | Did Not Play |
| WR | Mike Williams | LAC | DNP | 13.57 | 40.70 | Did Not Play |
| Pos. | Injured List | Proteam | TW | PPG | Total | Breakdown |
| QB | Justin Herbert | LAC | DNP | 21.13 | 274.72 | Did Not Play |