| Pos. | Starters | Proteam | TW | PPG | Total | Breakdown |
| QB | Brock Purdy | SF | 21.60 | 22.48 | 359.60 | 230 Pass, 4 Rush, 2 TD |
| RB | Saquon Barkley | NYG | 7.30 | 14.00 | 182.00 | 39 Rush, 19 Receiving, 3 Rec |
| RB | Tony Pollard | Dal | 5.40 | 11.28 | 180.50 | 49 Rush, 1 Rec |
| WR | Jordan Addison | Min | 4.30 | 10.79 | 172.60 | 28 Receiving, 3 Rec |
| WR | Tee Higgins | Cin | 2.40 | 9.72 | 116.60 | 19 Receiving, 1 Rec |
| WR | Courtland Sutton | Den | DNP | 0.00 | 0.00 | Did Not Play |
| TE | Dalton Schultz | Hou | 2.90 | 8.24 | 115.30 | 19 Receiving, 2 Rec |
| HB | Amari Cooper | Cle | DNP | 0.00 | 0.00 | Did Not Play |
| PK | Cameron Dicker | LAC | 13.00 | 8.50 | 136.00 | 1 FG(<40), 2 FG(50-59) |
| DL | Jonathon Cooper | Den | 5.00 | 7.88 | 126.00 | 1 Tackle, 1.0 Sack |
| DL | Aidan Hutchinson | Det | 20.00 | 7.00 | 112.00 | 5 Tackles, 3.0 Sacks, 1 FF |
| DL | Kayvon Thibodeaux | NYG | 2.00 | 6.75 | 108.00 | 2 Assists |
| LB | Alex Anzalone | Det | 8.00 | 9.33 | 140.00 | 5 Tackles, 3 Assists |
| LB | Nick Bolton | KC | 14.00 | 8.50 | 68.00 | 9 Tackles, 4 Assists, 1 PD |
| LB | Demario Davis | NO | 7.00 | 9.19 | 147.00 | 1 Tackle, 3 Assists, 1 Fum Rcvy |
| CB | Nate Hobbs | LV | 8.00 | 8.58 | 103.00 | 4 Tackles, 4 Assists |
| S | Jevon Holland | Mia | 7.00 | 8.91 | 98.00 | 3 Tackles, 1 Assist, 1 Fum Rcvy |
| Pos. | 1st Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Baker Mayfield | TB | 0(20.26) | 20.43 | 326.88 | 309 Pass, -1 Rush, 2 TD, 2 Int |
| RB | Dameon Pierce | Hou | 0(2.60) | 6.32 | 82.20 | 16 Rush, 5 Receiving, 1 Rec |
| WR | Garrett Wilson | NYJ | 7.40 | 10.21 | 163.30 | -1 Rush, 50 Receiving, 5 Rec |
| TE | Chig Okonkwo | Ten | 0(4.90) | 5.11 | 81.80 | 34 Receiving, 3 Rec |
| RB | Zamir White | LV | 13.10 | 3.65 | 54.80 | 71 Rush, 35 Receiving, 5 Rec |
| PK | Matt Gay | Ind | 0(12.00) | 9.00 | 144.00 | 2 FG(<40), 1 FG(40-49), 2 XP |
| DL | Jermaine Johnson | NYJ | 0(18.00) | 6.44 | 103.00 | 3 Tackles, 1 Int, 1 TD, 1 Fum Rcvy, 1 PD |
| LB | Christian Rozeboom | LAR | 0(3.00) | 5.19 | 83.00 | 2 Tackles, 1 Assist |
| CB | Charvarius Ward | SF | 0(10.00) | 7.81 | 125.00 | 3 Tackles, 1 Assist, 1 Int, 1 PD |
| S | Talanoa Hufanga | SF | DNP | 7.00 | 70.00 | Did Not Play |
| Pos. | 2nd Backup | Proteam | TW | PPG | Total | Breakdown |
| CB | Brandon Stephens | Bal | DNP | 0.00 | 0.00 | Did Not Play |
| Offense = 77.40 Defense = 71 Total = 148.40 | ||||||
| Pos. | Bench | Proteam | TW | PPG | Total | Breakdown |
| QB | Kyler Murray | Ari | 29.68 | 20.94 | 146.58 | 232 Pass, 24 Rush, 3 TD, 1 Int, 1 2-Pt |
| WR | Rondale Moore | Ari | 4.90 | 4.96 | 79.40 | 8 Rush, 26 Receiving, 3 Rec |
| DL | Za'Darius Smith | Cle | 1.00 | 3.44 | 55.00 | 1 Tackle |
| LB | Jamin Davis | Was | DNP | 8.92 | 116.00 | Did Not Play |
| S | Chauncey Gardner-Johnson | Det | DNP | 7.50 | 15.00 | Did Not Play |
| Pos. | Injured List | Proteam | TW | PPG | Total | Breakdown |
| WR | Mike Williams | LAC | DNP | 13.57 | 40.70 | Did Not Play |