| Pos. | Starters | Proteam | TW | PPG | Total | Breakdown |
| QB | Jared Goff | Det | 8.44 | 19.93 | 259.06 | 161 Pass, 1 TD, 2 Int |
| RB | David Montgomery | Det | 10.00 | 15.46 | 154.60 | 66 Rush, 19 Receiving, 3 Rec |
| RB | Tony Pollard | Dal | 13.10 | 12.58 | 163.60 | 59 Rush, 37 Receiving, 7 Rec |
| WR | Jakobi Meyers | LV | 5.00 | 11.17 | 134.00 | 25 Receiving, 5 Rec |
| WR | Tyler Lockett | Sea | 11.90 | 9.97 | 129.60 | 89 Receiving, 6 Rec |
| WR | Deebo Samuel | SF | 30.50 | 15.14 | 166.50 | 1 Rush, 149 Receiving, 7 Rec, 2 TD |
| TE | David Njoku | Cle | 24.10 | 8.65 | 112.50 | 91 Receiving, 6 Rec, 2 TD |
| HB | Bijan Robinson | Atl | 17.30 | 13.15 | 171.00 | 34 Rush, 54 Receiving, 5 Rec, 1 TD |
| PK | Jake Elliott | Phi | 10.00 | 9.31 | 121.00 | 1 FG(40-49), 1 FG(50-59), 1 XP |
| DL | Vita Vea | TB | DNP | 5.27 | 58.00 | Did Not Play |
| DL | Sam Hubbard | Cin | 3.00 | 6.45 | 71.00 | 2 Tackles, 1 Assist |
| DL | Shaquil Barrett | TB | 4.00 | 6.23 | 81.00 | 2 Tackles, 2 Assists |
| LB | Denzel Perryman | Hou | 6.00 | 7.13 | 57.00 | 1 Tackle, 3 Assists, 2 PD |
| LB | Jahlani Tavai | NE | 14.00 | 7.69 | 100.00 | 8 Tackles, 6 Assists |
| LB | Patrick Queen | Bal | 6.00 | 9.77 | 127.00 | 3 Tackles, 3 Assists |
| CB | Paulson Adebo | NO | 5.00 | 9.00 | 99.00 | 5 Tackles |
| S | Jessie Bates | Atl | 10.00 | 11.54 | 150.00 | 7 Tackles, 2 Assists, 1 PD |
| Pos. | 1st Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Geno Smith | Sea | DNP | 17.01 | 204.10 | Did Not Play |
| RB | Tyler Allgeier | Atl | 0(4.00) | 6.73 | 87.50 | 40 Rush |
| WR | Zay Jones | Jac | 0(5.40) | 6.43 | 45.00 | 29 Receiving, 5 Rec |
| TE | Tyler Conklin | NYJ | 0(7.70) | 5.66 | 73.60 | 57 Receiving, 4 Rec |
| WR | Rondale Moore | Ari | DNP | 5.24 | 68.10 | Team had a Bye |
| PK | Brandon McManus | Jac | 0(3.00) | 9.38 | 122.00 | 3 XP |
| DL | Baron Browning | Den | 5.00 | 5.86 | 41.00 | 4 Tackles, 1 PD |
| LB | Josey Jewell | Den | 0(17.00) | 8.42 | 101.00 | 4 Tackles, 5 Assists, 1.0 Sack, 1 Fum Rcvy, 1 PD |
| CB | Kenny Moore | Ind | 0(4.00) | 9.23 | 120.00 | 3 Tackles, 1 PD |
| S | Jevon Holland | Mia | DNP | 9.10 | 91.00 | Did Not Play |
| Pos. | 2nd Backup | Proteam | TW | PPG | Total | Breakdown |
| RB | Ezekiel Elliott | NE | 0(23.50) | 8.06 | 104.80 | 68 Rush, 72 Receiving, 7 Rec, 1 TD |
| WR | Treylon Burks | Ten | 0(1.10) | 2.67 | 18.70 | 5 Rush, 1 Receiving, 1 Rec |
| WR | Nelson Agholor | Bal | 0(5.70) | 5.16 | 61.90 | 32 Receiving, 5 Rec |
| Offense = 130.34 Defense = 53 Total = 183.34 | ||||||
| Pos. | Bench | Proteam | TW | PPG | Total | Breakdown |
| WR | DJ Chark | Car | 3.60 | 5.91 | 65.00 | 26 Receiving, 2 Rec |
| DL | Will Anderson | Hou | 0.00 | 4.92 | 64.00 | Played, No Stats |
| S | Harrison Smith | Min | 2.00 | 7.46 | 97.00 | 1 Tackle, 1 Assist |