| Pos. | Starters | Proteam | TW | PPG | Total | Breakdown |
| QB | Justin Herbert | LAC | 1.84 | 21.13 | 274.72 | 96 Pass, 1 Int |
| RB | Bijan Robinson | Atl | 17.30 | 13.15 | 171.00 | 34 Rush, 54 Receiving, 5 Rec, 1 TD |
| RB | Ty Chandler | Min | 5.70 | 3.22 | 41.80 | 35 Rush, 7 Receiving, 3 Rec |
| WR | Rashee Rice | KC | 15.70 | 10.04 | 130.50 | 72 Receiving, 7 Rec, 1 TD, 1 Fumb |
| WR | Jerry Jeudy | Den | 2.60 | 6.47 | 77.70 | 16 Receiving, 2 Rec |
| WR | D.K. Metcalf | Sea | 12.20 | 12.82 | 153.90 | 52 Receiving, 2 Rec, 1 TD |
| TE | Tyler Higbee | LAR | DNP | 5.47 | 65.70 | Did Not Play |
| HB | Dalvin Cook | NYJ | 1.30 | 2.55 | 33.20 | 13 Rush, -5 Receiving, 1 Rec |
| PK | Blake Grupe | NO | 3.00 | 8.77 | 114.00 | 4 XP, 1 Miss(<40) |
| DL | Harrison Phillips | Min | 8.00 | 6.31 | 82.00 | 3 Tackles, 1 Assist, 1.0 Sack |
| DL | Baron Browning | Den | 5.00 | 5.86 | 41.00 | 4 Tackles, 1 PD |
| DL | Chris Jones | KC | 0.00 | 4.75 | 57.00 | Played, No Stats |
| LB | Alex Singleton | Den | 19.00 | 11.77 | 153.00 | 10 Tackles, 4 Assists, 1.0 Sack, 1 PD |
| LB | Dre Greenlaw | SF | 4.00 | 8.42 | 101.00 | 2 Tackles, 2 Assists |
| LB | Devin Lloyd | Jac | 14.00 | 10.27 | 113.00 | 4 Tackles, 7 Assists, 1 Fum Rcvy |
| CB | Paulson Adebo | NO | 5.00 | 9.00 | 99.00 | 5 Tackles |
| S | Josh Metellus | Min | 10.00 | 9.00 | 117.00 | 4 Tackles, 3 Assists, 1 FF |
| Pos. | 1st Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Brock Purdy | SF | 0(25.42) | 23.22 | 301.92 | 368 Pass, 7 Rush, 2 TD, 1 Int |
| RB | D'Onta Foreman | Chi | 0(8.20) | 10.79 | 86.30 | 50 Rush, 22 Receiving, 2 Rec |
| WR | Treylon Burks | Ten | 0(1.10) | 2.67 | 18.70 | 5 Rush, 1 Receiving, 1 Rec |
| TE | Trey McBride | Ari | DNP | 7.77 | 101.00 | Team had a Bye |
| WR | Nick Westbrook-Ikhine | Ten | 0(5.80) | 5.17 | 67.20 | 28 Receiving, 2 Rec, 1 2-Pt |
| PK | Jason Myers | Sea | 0(5.00) | 9.23 | 120.00 | 1 FG(40-49), 1 XP |
| DL | Michael Hoecht | LAR | 0(7.00) | 6.46 | 84.00 | 4 Tackles, 3 Assists |
| LB | David Long | Mia | 0(8.00) | 7.23 | 94.00 | 5 Tackles, 3 Assists |
| CB | Devon Witherspoon | Sea | 0(1.00) | 8.92 | 107.00 | 1 PD |
| S | Minkah Fitzpatrick | Pit | 0(5.00) | 7.33 | 66.00 | 2 Tackles, 3 Assists |
| Offense = 59.64 Defense = 65 Total = 124.64 | ||||||
| Pos. | Bench | Proteam | TW | PPG | Total | Breakdown |
| QB | Matthew Stafford | LAR | 29.66 | 19.11 | 229.28 | 294 Pass, -1 Rush, 3 TD |
| RB | Brian Robinson | Was | DNP | 12.34 | 160.40 | Team had a Bye |
| RB | Cam Akers | Min | DNP | 5.89 | 41.20 | Did Not Play |
| TE | Zach Ertz | Ari | DNP | 5.46 | 38.20 | Team had a Bye |
| DL | Cameron Heyward | Pit | 10.00 | 4.71 | 33.00 | 5 Tackles, 1 Assist, 1.0 Sack |
| LB | Drue Tranquill | KC | DNP | 7.67 | 92.00 | Did Not Play |
| Pos. | Injured List | Proteam | TW | PPG | Total | Breakdown |
| LB | Jordan Hicks | Min | DNP | 11.50 | 115.00 | Did Not Play |