| Pos. | Starters | Proteam | TW | PPG | Total | Breakdown |
| QB | Derek Carr | NO | 19.58 | 16.18 | 258.96 | 197 Pass, -3 Rush, 2 TD |
| RB | Derrick Henry | Ten | 4.20 | 13.46 | 215.36 | 42 Rush |
| RB | Joe Mixon | Cin | 16.70 | 13.55 | 216.80 | 65 Rush, 22 Receiving, 4 Rec, 1 TD |
| WR | Noah Brown | Hou | 1.30 | 8.51 | 85.10 | 8 Receiving, 1 Rec |
| WR | Puka Nacua | LAR | 16.20 | 14.62 | 233.90 | 19 Rush, 118 Receiving, 5 Rec |
| WR | Demarcus Robinson | LAR | 11.20 | 5.03 | 75.40 | 92 Receiving, 6 Rec, 1 Fumb |
| TE | Jake Ferguson | Dal | 5.30 | 8.23 | 131.70 | 33 Receiving, 4 Rec |
| HB | George Pickens | Pit | 16.60 | 11.06 | 177.00 | 131 Receiving, 7 Rec |
| PK | Brandon McManus | Jac | 14.00 | 8.56 | 137.00 | 4 FG(<40), 2 XP |
| DL | Danielle Hunter | Min | 3.00 | 9.56 | 153.00 | 1 Tackle, 2 Assists |
| DL | Montez Sweat | Chi | 1.00 | 7.25 | 116.00 | 1 Assist |
| DL | T.J. Watt | Pit | 2.00 | 10.50 | 168.00 | 1 Tackle, 1 Assist |
| LB | Bobby Okereke | NYG | 16.00 | 11.19 | 179.00 | 2 Tackles, 8 Assists, 1.5 Sacks |
| LB | Duke Riley | Mia | 6.00 | 2.75 | 44.00 | 5 Tackles, 1 Assist |
| LB | Robert Spillane | LV | 6.00 | 10.94 | 175.00 | 5 Tackles, 1 Assist |
| CB | Roger McCreary | Ten | 7.00 | 7.00 | 98.00 | 6 Tackles, 1 Assist |
| S | Brandon Jones | Mia | 0.00 | 4.00 | 60.00 | Played, No Stats |
| Pos. | 1st Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Jarrett Stidham | Den | 0(15.56) | 2.22 | 15.56 | 224 Pass, 6 Rush, 1 TD |
| RB | Tyjae Spears | Ten | 0(4.90) | 6.73 | 107.70 | 29 Receiving, 4 Rec |
| TE | Kyle Pitts | Atl | 0(1.00) | 6.69 | 107.10 | 5 Receiving, 1 Rec |
| RB | Samaje Perine | Den | 0(3.60) | 5.86 | 93.70 | 10 Rush, 16 Receiving, 2 Rec |
| DL | Chase Young | SF | 0(1.00) | 3.73 | 56.00 | 1 Tackle |
| LB | Logan Wilson | Cin | 0(5.00) | 10.50 | 168.00 | 2 Tackles, 3 Assists |
| Pos. | 2nd Backup | Proteam | TW | PPG | Total | Breakdown |
| RB | Antonio Gibson | Was | 0(4.60) | 6.69 | 100.30 | 19 Rush, 17 Receiving, 2 Rec |
| WR | Alec Pierce | Ind | 0(12.30) | 4.96 | 79.40 | 58 Receiving, 1 Rec, 1 TD |
| WR | A.T. Perry | NO | 0(1.00) | 3.58 | 35.80 | 5 Receiving, 1 Rec |
| DL | George Karlaftis | KC | 0(11.00) | 5.94 | 95.00 | 4 Tackles, 1 Assist, 1.5 Sacks |
| LB | Kaden Elliss | Atl | 0(13.00) | 8.63 | 138.00 | 6 Tackles, 3 Assists, 1.0 Sack |
| Offense = 105.08 Defense = 41 Total = 146.08 | ||||||
| Pos. | Bench | Proteam | TW | PPG | Total | Breakdown |
| WR | Justyn Ross | KC | 0.00 | 0.56 | 5.60 | Played, No Stats |
| WR | Courtland Sutton | Den | DNP | 0.00 | 0.00 | Did Not Play |
| DL | Dayo Odeyingbo | Ind | 2.00 | 5.25 | 84.00 | 1 Tackle, 1 Assist |
| LB | Lavonte David | TB | 11.00 | 10.71 | 150.00 | 5 Tackles, 6 Assists |
| LB | Byron Young | LAR | 8.00 | 5.88 | 94.00 | 4 Tackles, 1.0 Sack |
| Pos. | Injured List | Proteam | TW | PPG | Total | Breakdown |
| WR | Christian Kirk | Jac | DNP | 10.31 | 123.76 | Did Not Play |