| Pos. | Starters | Proteam | TW | PPG | Total | Breakdown |
| QB | Baker Mayfield | TB | 6.18 | 19.59 | 333.06 | 137 Pass, 7 Rush |
| RB | David Montgomery | Det | 10.00 | 14.30 | 200.20 | 40 Rush, 1 TD |
| RB | D'Andre Swift | Phi | DNP | 11.30 | 180.80 | Did Not Play |
| WR | Brandon Aiyuk | SF | 4.00 | 13.29 | 212.70 | 25 Receiving, 3 Rec |
| WR | Stefon Diggs | Buf | 12.20 | 13.02 | 221.30 | 87 Receiving, 7 Rec |
| WR | Chris Olave | NO | 13.10 | 11.74 | 187.80 | 56 Receiving, 3 Rec, 1 TD |
| TE | Darren Waller | NYG | 7.00 | 7.27 | 87.20 | 45 Receiving, 5 Rec |
| HB | Javonte Williams | Den | 17.00 | 9.79 | 156.70 | 32 Rush, 43 Receiving, 7 Rec, 1 TD |
| PK | Greg Zuerlein | NYJ | 10.00 | 8.81 | 141.00 | 2 FG(<40), 1 FG(40-49) |
| DL | Javon Hargrave | SF | 0.00 | 4.56 | 73.00 | Played, No Stats |
| DL | Kwity Paye | Ind | 2.00 | 6.13 | 98.00 | 1 Tackle, 1 Assist |
| DL | Da'Ron Payne | Was | 3.00 | 5.00 | 85.00 | 1 Tackle, 2 Assists |
| LB | Micah McFadden | NYG | 14.00 | 7.94 | 127.00 | 7 Tackles, 2 Assists, 1 Fum Rcvy, 2 PD |
| LB | Germaine Pratt | Cin | 3.00 | 8.71 | 148.00 | 1 Tackle, 1 Assist, 1 PD |
| LB | Bobby Wagner | Sea | 15.00 | 12.00 | 204.00 | 4 Tackles, 11 Assists |
| CB | Rasul Douglas | Buf | 0.00 | 7.44 | 119.00 | Played, No Stats |
| S | Jessie Bates | Atl | 4.00 | 11.06 | 188.00 | 4 Tackles |
| Pos. | 1st Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | C.J. Beathard | Jac | 0 | 2.35 | 23.46 | Played, No Stats |
| RB | Clyde Edwards-Helaire | KC | 1.50 | 4.11 | 61.60 | 1 Rush, 9 Receiving, 1 Rec |
| WR | Brandin Cooks | Dal | 0(13.20) | 9.14 | 146.20 | 3 Rush, 39 Receiving, 6 Rec, 1 TD |
| TE | Cade Otton | TB | 0(4.00) | 5.53 | 94.00 | 30 Receiving, 2 Rec |
| WR | Michael Gallup | Dal | 0 | 4.16 | 70.80 | Played, No Stats |
| DL | B.J. Hill | Cin | 0(6.00) | 4.94 | 84.00 | 2 Tackles, 2 Assists, 0.5 Sack |
| LB | Jahlani Tavai | NE | 0(6.00) | 7.76 | 132.00 | 6 Tackles |
| CB | Benjamin St-Juste | Was | 0(4.00) | 6.13 | 98.00 | 4 Tackles |
| S | Justin Simmons | Den | 0(3.00) | 7.07 | 106.00 | 3 Tackles |
| Pos. | 2nd Backup | Proteam | TW | PPG | Total | Breakdown |
| RB | Kenneth Gainwell | Phi | 0(6.20) | 5.21 | 83.38 | 62 Rush |
| WR | Robert Woods | Hou | DNP | 4.95 | 69.30 | Did Not Play |
| RB | Jamaal Williams | NO | 0(10.90) | 3.98 | 51.80 | 26 Rush, 8 Receiving, 3 Rec, 1 TD |
| Offense = 80.98 Defense = 41 Total = 121.98 | ||||||
| Pos. | Bench | Proteam | TW | PPG | Total | Breakdown |
| QB | Trevor Lawrence | Jac | 20.20 | 19.47 | 311.54 | 280 Pass, 10 Rush, 2 TD, 2 Int |
| QB | Aaron Rodgers | NYJ | DNP | 0.00 | 0.00 | Did Not Play |
| RB | Jerick McKinnon | KC | DNP | 6.16 | 73.96 | Did Not Play |
| WR | Keenan Allen | LAC | DNP | 17.51 | 227.66 | Did Not Play |
| Pos. | Injured List | Proteam | TW | PPG | Total | Breakdown |
| LB | Jerome Baker | Mia | 9.00 | 7.29 | 102.00 | |