| Pos. | Starters | Proteam | TW | PPG | Total | Breakdown |
| QB | Matthew Stafford | LAR | 22.52 | 19.37 | 251.80 | 258 Pass, 2 Rush, 2 TD |
| RB | Dalvin Cook | NYJ | 1.50 | 2.48 | 34.70 | 4 Rush, 6 Receiving, 1 Rec |
| RB | Raheem Mostert | Mia | 17.30 | 17.48 | 244.70 | 42 Rush, 1 Receiving, 2 Rec, 2 TD |
| WR | Tyreek Hill | Mia | DNP | 21.17 | 275.20 | Did Not Play |
| WR | Jerry Jeudy | Den | 8.90 | 6.66 | 86.60 | 74 Receiving, 3 Rec |
| WR | Drake London | Atl | 3.40 | 9.29 | 120.78 | 24 Receiving, 2 Rec |
| TE | Sam LaPorta | Det | 26.10 | 12.12 | 169.70 | 56 Receiving, 5 Rec, 3 TD |
| HB | Evan Engram | Jac | 4.80 | 9.58 | 134.10 | 28 Receiving, 4 Rec |
| PK | Younghoe Koo | Atl | 1.00 | 7.71 | 108.00 | 1 XP |
| DL | DeForest Buckner | Ind | 6.00 | 8.00 | 112.00 | 3 Tackles, 1 Assist, 0.5 Sack |
| DL | Josh Sweat | Phi | 1.00 | 0.00 | 0.00 | |
| DL | Quinnen Williams | NYJ | 5.00 | 5.93 | 83.00 | 2 Tackles, 1 Assist, 0.5 Sack |
| LB | Alex Anzalone | Det | 13.00 | 9.85 | 128.00 | 7 Tackles, 5 Assists, 1 PD |
| LB | T.J. Edwards | Chi | 10.00 | 12.21 | 171.00 | 1 Tackle, 5 Assists, 0.5 Sack, 2 PD |
| LB | Zaire Franklin | Ind | 6.00 | 12.77 | 166.00 | 2 Tackles, 3 Assists, 1 PD |
| CB | D.J. Reed | NYJ | 8.00 | 6.92 | 83.00 | 3 Tackles, 4 Assists, 1 PD |
| S | Harrison Smith | Min | 6.00 | 7.36 | 103.00 | 5 Tackles, 1 PD |
| Pos. | 1st Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Gardner Minshew | Ind | 0(26.60) | 14.02 | 196.26 | 215 Pass, 3 TD |
| RB | Royce Freeman | LAR | 0(1.60) | 4.86 | 43.70 | 16 Rush |
| WR | Nick Westbrook-Ikhine | Ten | 3.80 | 5.07 | 71.00 | 33 Receiving, 1 Rec |
| TE | Donald Parham | LAC | DNP | 4.24 | 55.10 | Did Not Play |
| WR | Josh Reynolds | Det | 0(5.10) | 7.07 | 99.00 | 41 Receiving, 2 Rec |
| RB | Jamaal Williams | NO | 0(3.10) | 3.00 | 30.00 | 24 Rush, 2 Receiving, 1 Rec |
| PK | Greg Joseph | Min | 0(6.00) | 6.86 | 96.00 | 1 FG(<40), 3 XP |
| DL | Jonathan Allen | Was | 0(4.00) | 4.71 | 66.00 | 1 Tackle, 3 Assists |
| LB | Dre Greenlaw | SF | 0(8.00) | 8.38 | 109.00 | 7 Tackles, 1 Assist |
| CB | L'Jarius Sneed | KC | 0(11.00) | 7.14 | 100.00 | 8 Tackles, 1 Assist, 2 PD |
| S | Budda Baker | Ari | 0(5.00) | 7.00 | 63.00 | 3 Tackles, 2 Assists |
| Pos. | 2nd Backup | Proteam | TW | PPG | Total | Breakdown |
| RB | Craig Reynolds | Det | 0 | 2.08 | 29.10 | Played, No Stats |
| WR | Keenan Allen | LAC | DNP | 17.51 | 227.66 | Did Not Play |
| LB | Christian Rozeboom | LAR | 0(6.00) | 5.36 | 75.00 | 4 Tackles, 1 Assist, 1 PD |
| Offense = 89.32 Defense = 55 Total = 144.32 | ||||||
| Pos. | Bench | Proteam | TW | PPG | Total | Breakdown |
| RB | Deon Jackson | NYG | 0.00 | 0.50 | 3.50 | Played, No Stats |
| WR | Josh Downs | Ind | 3.40 | 7.40 | 103.60 | 19 Receiving, 3 Rec |
| Pos. | Injured List | Proteam | TW | PPG | Total | Breakdown |
| QB | Anthony Richardson | Ind | DNP | 19.92 | 79.68 | Did Not Play |