| Pos. | Starters | Proteam | TW | PPG | Total | Breakdown |
| QB | Trevor Lawrence | Jac | 23.38 | 20.03 | 260.34 | 257 Pass, 11 Rush, 3 TD, 3 Int |
| RB | Miles Sanders | Car | 7.40 | 5.63 | 67.50 | 74 Rush |
| RB | Saquon Barkley | NYG | 22.60 | 15.21 | 152.10 | 86 Rush, 15 Receiving, 3 Rec, 2 TD, 1 Fumb |
| WR | Adam Thielen | Car | 9.90 | 11.68 | 151.80 | 74 Receiving, 5 Rec |
| WR | Tyler Lockett | Sea | 11.90 | 9.97 | 129.60 | 89 Receiving, 6 Rec |
| WR | Stefon Diggs | Buf | 4.40 | 14.75 | 191.80 | 24 Receiving, 4 Rec |
| TE | George Kittle | SF | 15.10 | 11.06 | 143.80 | 76 Receiving, 3 Rec, 1 TD |
| HB | Odell Beckham | Bal | 17.70 | 7.55 | 83.00 | 97 Receiving, 4 Rec, 1 TD |
| PK | Evan McPherson | Cin | 10.00 | 8.85 | 115.00 | 2 FG(<40), 4 XP |
| DL | Kwity Paye | Ind | 2.00 | 6.92 | 83.00 | 1 Tackle, 1 Assist |
| DL | Javon Hargrave | SF | 1.00 | 5.00 | 65.00 | 1 Tackle |
| DL | Christian Wilkins | Mia | 9.00 | 6.69 | 87.00 | 3 Tackles, 2 Assists, 1.0 Sack |
| LB | Josey Jewell | Den | 17.00 | 8.42 | 101.00 | 4 Tackles, 5 Assists, 1.0 Sack, 1 Fum Rcvy, 1 PD |
| LB | Demario Davis | NO | 15.00 | 9.23 | 120.00 | 5 Tackles, 3 Assists, 1.5 Sacks, 1 PD |
| LB | Patrick Queen | Bal | 6.00 | 9.77 | 127.00 | 3 Tackles, 3 Assists |
| CB | Rasul Douglas | Buf | 4.00 | 7.25 | 87.00 | 3 Assists, 1 PD |
| S | Andre Cisco | Jac | 3.00 | 6.67 | 80.00 | 3 Tackles |
| Pos. | 1st Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Zach Wilson | NYJ | 0(24.24) | 12.99 | 142.90 | 301 Pass, 12 Rush, 2 TD, 1 Fumb |
| RB | Jerick McKinnon | KC | 0(11.20) | 5.21 | 57.30 | 19 Rush, 18 Receiving, 3 Rec, 1 TD |
| WR | Robert Woods | Hou | 0(0.30) | 4.90 | 53.90 | -2 Receiving, 1 Rec |
| TE | Gerald Everett | LAC | 0(6.40) | 5.88 | 64.70 | 39 Receiving, 5 Rec |
| RB | Latavius Murray | Buf | 0(3.50) | 5.18 | 67.30 | 9 Rush, 21 Receiving, 1 Rec |
| PK | Younghoe Koo | Atl | 0(5.00) | 8.23 | 107.00 | 1 FG(<40), 2 XP |
| DL | B.J. Hill | Cin | 0(8.00) | 4.31 | 56.00 | 2 Tackles, 1 Int, 1 PD |
| CB | Tavierre Thomas | Hou | 0(1.00) | 6.22 | 56.00 | 1 Tackle |
| S | Josh Metellus | Min | 0(10.00) | 9.00 | 117.00 | 4 Tackles, 3 Assists, 1 FF |
| Pos. | 2nd Backup | Proteam | TW | PPG | Total | Breakdown |
| RB | Elijah Mitchell | SF | DNP | 1.87 | 16.80 | Did Not Play |
| LB | Cole Holcomb | Pit | DNP | 8.25 | 66.00 | Did Not Play |
| Offense = 122.38 Defense = 57 Total = 179.38 | ||||||
| Pos. | Bench | Proteam | TW | PPG | Total | Breakdown |
| RB | Jonathan Taylor | Ind | DNP | 13.30 | 93.10 | Did Not Play |
| RB | Cam Akers | Min | DNP | 5.89 | 41.20 | Did Not Play |
| RB | D'Onta Foreman | Chi | 8.20 | 10.79 | 86.30 | 50 Rush, 22 Receiving, 2 Rec |
| WR | Michael Thomas | NO | DNP | 7.03 | 70.30 | Did Not Play |
| LB | Jamin Davis | Was | DNP | 8.92 | 116.00 | Team had a Bye |