| Pos. | Starters | Proteam | TW | PPG | Total | Breakdown |
| QB | Drew Brees | NO | 5.92 | 25.04 | 350.54 | 203 Pass, - 2 Rush, 1 Int |
| RB | Phillip Lindsay | Den | 6.40 | 14.19 | 198.60 | 24 Rush, 20 Receiving, 4 Rec |
| RB | Mike Davis | Sea | 12.40 | 8.01 | 104.10 | 21 Rush, 63 Receiving, 8 Rec |
| WR | Julian Edelman | NE | 12.50 | 13.66 | 136.62 | 90 Receiving, 7 Rec |
| WR | Davante Adams | GB | 17.90 | 18.25 | 255.50 | 119 Receiving, 8 Rec, 1 2-Pt |
| WR | Amari Cooper | Dal | 6.30 | 13.18 | 171.30 | 11 Rush, 32 Receiving, 4 Rec |
| TE | Eric Ebron | Ind | 1.30 | 12.28 | 171.90 | 8 Receiving, 1 Rec |
| HB | Tyler Lockett | Sea | 6.60 | 12.01 | 168.10 | 11 Rush, 45 Receiving, 2 Rec |
| PK | Harrison Butker | KC | 4.00 | 8.93 | 125.00 | 4 XP |
| DL | Chris Jones | KC | 14.00 | 8.21 | 115.00 | 2 Tackles, 1 Assist, 2.5 Sacks, 1 PD |
| DL | Jurrell Casey | Ten | 5.00 | 6.71 | 94.00 | 2 Assists, 1 Fum Rcvy |
| DL | Chandler Jones | Ari | 2.00 | 7.57 | 106.00 | 1 Tackle, 1 Assist |
| LB | Bobby Wagner | Sea | 7.00 | 11.31 | 147.00 | 6 Tackles, 1 Assist |
| LB | Von Miller | Den | 6.00 | 9.00 | 126.00 | 2 Tackles, 1.0 Sack |
| LB | Tremaine Edmunds | Buf | 8.00 | 9.38 | 122.00 | 5 Tackles, 3 Assists |
| CB | Kyle Fuller | Chi | 4.00 | 7.43 | 104.00 | 2 Tackles, 2 PD |
| S | Antoine Bethea | Ari | 5.00 | 8.93 | 125.00 | 4 Tackles, 1 Assist |
| Pos. | 1st Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Josh Allen | Buf | 0(21.76) | 16.99 | 169.92 | 204 Pass, 16 Rush, 2 TD |
| RB | Zach Zenner | Det | 0(12.00) | 6.47 | 25.90 | 45 Rush, 3 Rec, 1 TD |
| TE | Trey Burton | Chi | 0(11.60) | 7.84 | 109.80 | 36 Receiving, 4 Rec, 1 TD |
| WR | Golden Tate | Phi | 0(6.80) | 10.64 | 138.30 | 43 Receiving, 5 Rec |
| PK | Jake Elliott | Phi | 0(15.00) | 7.50 | 105.00 | 1 FG(<40), 1 FG(40-49), 1 FG(50-59), 3 XP |
| DL | Damon Harrison | Det | 0(6.00) | 6.40 | 96.00 | 5 Tackles, 1 Assist |
| LB | Benardrick McKinney | Hou | 0(11.00) | 7.64 | 107.00 | 3 Tackles, 6 Assists, 2 PD |
| CB | James Bradberry | Car | 0(9.00) | 5.93 | 83.00 | 2 Tackles, 1 Assist, 1 Int, 1 PD |
| S | Clayton Geathers | Ind | 0(8.00) | 7.92 | 95.00 | 6 Tackles, 2 Assists |
| Pos. | 2nd Backup | Proteam | TW | PPG | Total | Breakdown |
| RB | Stevan Ridley | Pit | 0(1.60) | 1.59 | 15.90 | 16 Rush |
| Offense = 73.32 Defense = 51 Total = 124.32 | ||||||
| Pos. | Bench | Proteam | TW | PPG | Total | Breakdown |
| RB | T.J. Yeldon | Jac | 1.60 | 10.47 | 146.60 | 6 Rush, 5 Receiving, 1 Rec |
| RB | Duke Johnson | Cle | 7.30 | 6.86 | 96.00 | 28 Rush, 25 Receiving, 4 Rec |
| RB | Isaiah Crowell | NYJ | 0.00 | 9.30 | 130.20 | Played, No Stats |
| RB | Jalen Richard | Oak | 9.10 | 7.76 | 108.70 | 9 Rush, 67 Receiving, 5 Rec, 1 Fumb |
| RB | James Conner | Pit | DNP | 20.30 | 243.60 | Did Not Play |
| WR | DeVante Parker | Mia | 0.00 | 5.18 | 46.60 | Played, No Stats |