| Position | Starters | Proteam | TW | PPG | Total | Breakdown |
|---|---|---|---|---|---|---|
| QB | Kyler Murray | Ari | 19.1 | 0.00 | 0 | |
| RB | Rex Burkhead | Hou | 8.1 | 0.00 | 0 | |
| RB | Alvin Kamara | NO | 17.2 | 16.25 | 211.20 | 146 Rush, 16 Receiving, 2 Rec |
| WR | Christian Kirk | Jac | 5.3 | 0.00 | 0 | |
| WR | Cooper Kupp | LAR | 23.1 | 0.00 | 0 | |
| WR | Cordarrelle Patterson | Atl | 1.7 | 13.04 | 208.60 | 11 Rush, 1 Receiving, 1 Rec |
| TE | Dawson Knox | Buf | 6.8 | 9.31 | 139.60 | 4 Rush, 49 Receiving, 3 Rec |
| HB (RB) | Samaje Perine | Cin | DNP | 4.65 | 69.70 | Did Not Play |
| PK | Tyler Bass | Buf | 10.0 | 8.35 | 142.00 | 1 FG(<40), 1 FG(40-49), 3 XP |
| DL | Carlos Dunlap | Sea | 12.0 | 0.00 | 0 | |
| DL | Yannick Ngakoue | LV | DNP | 4.75 | 76.00 | Did Not Play |
| DL | Da'Ron Payne | Was | 6.0 | 0.00 | 0 | |
| LB | Cole Holcomb | Was | 11.0 | 0.00 | 0 | |
| LB | Deion Jones | Atl | 6.0 | 9.75 | 156.00 | 4 Tackles, 2 Assists |
| LB | T.J. Watt | Pit | 10.0 | 0.00 | 0 | |
| CB | Logan Ryan | NYG | 11.0 | 0.00 | 0 | |
| S | Harrison Smith | Min | 6.0 | 0.00 | 0 | |
| Position | 1st Backups | Proteam | TW | PPG | Total | Breakdown |
| QB | Colt McCoy | NYG | DNP | 6.04 | 48.30 | Did Not Play |
| RB | Nyheim Hines | Ind | 0(2.9) | 0.00 | 0 | |
| WR | A.J. Green | Ari | 0(4.3) | 0.00 | 0 | |
| TE | Tyler Higbee | LAR | 0(20.5) | 0.00 | 0 | |
| HB (WR) | Chase Claypool | Pit | 15.5 | 0.00 | 0 | |
| PK | Randy Bullock | Ten | 0(4.0) | 0.00 | 0 | |
| DL | Dante Fowler | Atl | 3.0 | 4.64 | 65.00 | 1 Tackle, 2 Assists |
| LB | Robert Quinn | Chi | 0(3.0) | 0.00 | 0 | |
| CB | A.J. Terrell | Atl | 0(7.0) | 7.38 | 118.00 | 4 Tackles, 2 Assists, 1 PD |
| S | Micah Hyde | Buf | 0(1.0) | 7.53 | 128.00 | 1 Tackle |
| Position | 2nd Backups | Proteam | TW | PPG | Total | Breakdown |
| QB | Tyler Huntley | Bal | 0(7.84) | 0.00 | 0 | |
| RB | Darrel Williams | KC | 0(6.2) | 10.15 | 172.50 | 17 Rush, 30 Receiving, 3 Rec |
| WR | Tyreek Hill | Mia | 0(0.7) | 0.00 | 0 | |
| HB (RB) | Justin Jackson | LAC | 0(2.0) | 0.00 | 0 | |
| Offense = 106.8 Defense = 65 Total = 171.8 | ||||||
| Position | Bench | Proteam | TW | PPG | Total | Breakdown |
| HB (RB) | Chase Edmonds | Ari | DNP | 10.23 | 122.80 | Did Not Play |
| HB (RB) | Joe Mixon | Cin | DNP | 16.74 | 267.90 | Did Not Play |