| Pos. | Starters | Proteam | TW | PPG | Total | Breakdown |
| QB | Joe Burrow | Cin | DNP | 27.27 | 409.10 | Did Not Play |
| RB | Austin Ekeler | LAC | 30.10 | 19.64 | 314.20 | 122 Rush, 39 Receiving, 4 Rec, 2 TD |
| RB | Christian McCaffrey | SF | 28.30 | 18.78 | 300.46 | 121 Rush, 72 Receiving, 6 Rec, 1 TD |
| WR | A.J. Brown | Phi | 17.70 | 15.38 | 246.10 | 97 Receiving, 4 Rec, 1 TD |
| WR | Gabriel Davis | Buf | DNP | 10.23 | 143.20 | Did Not Play |
| WR | Mike Williams | LAC | 12.90 | 11.65 | 139.80 | 94 Receiving, 7 Rec |
| TE | George Kittle | SF | 10.30 | 11.04 | 154.60 | 23 Receiving, 4 Rec, 1 TD |
| HB | Brian Robinson | Was | 8.70 | 9.02 | 108.20 | 87 Rush |
| PK | Evan McPherson | Cin | DNP | 7.80 | 117.00 | Did Not Play |
| DL | DeForest Buckner | Ind | 5.00 | 7.19 | 115.00 | 4 Tackles, 1 Assist |
| DL | Sam Hubbard | Cin | DNP | 6.36 | 89.00 | Did Not Play |
| DL | Josh Sweat | Phi | 1.00 | 6.63 | 106.00 | 1 Assist |
| LB | T.J. Edwards | Phi | 11.00 | 10.44 | 167.00 | 9 Tackles, 2 Assists |
| LB | Willie Gay | KC | 7.00 | 9.42 | 113.00 | 5 Tackles, 2 Assists |
| LB | Quincy Williams | NYJ | 10.00 | 7.31 | 117.00 | 4 Tackles, 6 Assists |
| CB | Kyler Gordon | Chi | 7.00 | 7.00 | 98.00 | 6 Tackles, 1 Assist |
| S | Donovan Wilson | Dal | 6.00 | 8.00 | 128.00 | 1 Tackle, 1 Assist, 1.0 Sack |
| Pos. | 1st Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Justin Fields | Chi | 19.20 | 22.13 | 331.98 | 75 Pass, 132 Rush, 1 TD, 1 Int, 1 Fumb |
| RB | Isiah Pacheco | KC | 0(11.90) | 7.38 | 118.10 | 31 Rush, 18 Receiving, 2 Rec, 1 TD |
| WR | D.J. Moore | Car | 20.60 | 10.38 | 166.00 | - 1 Rush, 117 Receiving, 6 Rec, 1 TD |
| TE | Noah Fant | Sea | 0(5.00) | 5.85 | 93.60 | 40 Receiving, 2 Rec |
| RB | D'Onta Foreman | Car | 0(3.50) | 7.61 | 121.70 | 35 Rush |
| DL | Grover Stewart | Ind | 2.00 | 5.56 | 89.00 | 1 Tackle, 1 Assist |
| LB | Jerome Baker | Mia | 0(6.00) | 7.50 | 120.00 | 3 Tackles, 2 Assists, 1 PD |
| CB | Jeff Okudah | Det | 0(1.00) | 6.27 | 94.00 | 1 Assist |
| Pos. | 2nd Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Deshaun Watson | Cle | 0(27.86) | 15.60 | 77.98 | 169 Pass, 31 Rush, 3 TD |
| WR | Jameson Williams | Det | 0(4.00) | 2.90 | 14.50 | 40 Rush |
| WR | Allen Lazard | GB | 0(8.40) | 9.48 | 132.70 | 59 Receiving, 5 Rec |
| LB | Deion Jones | Cle | 0(4.00) | 5.80 | 58.00 | 1 Tackle, 3 Assists |
| Offense = 147.80 Defense = 49 Total = 196.80 | ||||||
| Pos. | Bench | Proteam | TW | PPG | Total | Breakdown |
| QB | Kenny Pickett | Pit | 12.92 | 12.41 | 148.96 | 168 Pass, 2 Rush, 1 TD |
| RB | Kenneth Gainwell | Phi | 2.70 | 4.48 | 71.70 | 17 Receiving, 2 Rec |
| RB | Antonio Gibson | Was | DNP | 9.53 | 142.90 | Did Not Play |
| DL | Jeffery Simmons | Ten | DNP | 6.43 | 90.00 | Did Not Play |
| Pos. | Injured List | Proteam | TW | PPG | Total | Breakdown |
| WR | Darnell Mooney | Chi | DNP | 6.79 | 81.50 | Did Not Play |