| Pos. | Starters | Proteam | TW | PPG | Total | Breakdown |
| QB | Jalen Hurts | Phi | 8.46 | 28.27 | 424.04 | 229 Pass, 13 Rush, 1 Int |
| RB | Kenneth Walker | Sea | 12.90 | 12.61 | 189.10 | 114 Rush, 10 Receiving, 1 Rec |
| RB | Christian McCaffrey | SF | 15.40 | 18.58 | 315.86 | 45 Rush, 34 Receiving, 3 Rec, 1 TD |
| WR | Tyreek Hill | Mia | 3.30 | 16.92 | 287.70 | 23 Receiving, 2 Rec |
| WR | Amari Cooper | Cle | 6.10 | 12.18 | 207.00 | 51 Receiving, 2 Rec |
| WR | Michael Pittman | Ind | 10.50 | 10.50 | 168.00 | 30 Receiving, 3 Rec, 1 TD |
| TE | Daniel Bellinger | NYG | DNP | 5.08 | 61.00 | Did Not Play |
| HB | AJ Dillon | GB | 3.30 | 9.04 | 153.60 | 33 Rush |
| PK | Robbie Gould | SF | 8.00 | 8.18 | 139.00 | 1 FG(<40), 5 XP |
| DL | Chris Jones | KC | 15.00 | 7.00 | 119.00 | 3 Tackles, 2 Assists, 2.5 Sacks |
| DL | Quinnen Williams | NYJ | 4.00 | 7.25 | 116.00 | 1 Tackle, 3 Assists |
| DL | Brian Burns | Car | DNP | 7.44 | 119.00 | Did Not Play |
| LB | Josey Jewell | Den | 8.00 | 12.46 | 162.00 | 5 Tackles, 1 Fum Rcvy |
| LB | Foyesade Oluokun | Jac | 18.00 | 12.29 | 209.00 | 8 Tackles, 5 Assists, 1.0 Sack, 1 PD |
| LB | Nick Bolton | KC | 16.00 | 11.94 | 203.00 | 8 Tackles, 8 Assists |
| CB | Taron Johnson | Buf | 9.00 | 6.75 | 108.00 | 6 Tackles, 2 Assists, 1 PD |
| S | Grant Delpit | Cle | 2.00 | 7.82 | 133.00 | 1 Tackle, 1 Assist |
| Pos. | 1st Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Brock Purdy | SF | 0(25.82) | 14.70 | 132.26 | 178 Pass, 7 Rush, 3 TD |
| RB | Khalil Herbert | Chi | 0(5.40) | 8.72 | 113.40 | 50 Rush, - 1 Receiving, 1 Rec |
| WR | George Pickens | Pit | 0(14.70) | 8.26 | 140.50 | 72 Receiving, 3 Rec, 1 TD |
| TE | Gerald Everett | LAC | 8.30 | 6.91 | 110.50 | 8 Receiving, 3 Rec, 1 TD |
| WR | Richie James | NYG | 0 | 6.29 | 107.00 | Played, No Stats |
| PK | Wil Lutz | NO | 0(1.00) | 6.65 | 113.00 | 1 XP |
| DL | Zach Sieler | Mia | 3.00 | 5.59 | 95.00 | 1 Tackle, 2 Assists |
| LB | Christian Harris | Hou | 0(15.00) | 6.57 | 92.00 | 6 Tackles, 4 Assists, 1.0 Sack, 1 PD |
| CB | Ifeatu Melifonwu | Det | 0(1.00) | 1.80 | 18.00 | 1 Assist |
| S | Kerby Joseph | Det | 0(12.00) | 7.00 | 119.00 | 5 Tackles, 1 Int, 2 PD |
| Pos. | 2nd Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Gardner Minshew | Phi | DNP | 8.76 | 43.82 | Did Not Play |
| WR | Jameson Williams | Det | 0 | 2.42 | 14.50 | Played, No Stats |
| TE | Austin Hooper | Ten | 0(5.80) | 4.52 | 76.90 | 38 Receiving, 4 Rec |
| WR | Chris Moore | Hou | 0(3.00) | 5.69 | 91.10 | - 2 Rush, 22 Receiving, 2 Rec |
| DL | Montez Sweat | Was | 0(2.00) | 4.71 | 80.00 | 1 Tackle, 1 Assist |
| LB | Ernest Jones | LAR | 0(5.00) | 7.35 | 125.00 | 4 Tackles, 1 Assist |