| Pos. | Starters | Proteam | TW | PPG | Total | Breakdown |
| QB | Baker Mayfield | LAR | 5.08 | 12.54 | 137.94 | 132 Pass, 8 Rush, 1 Fumb |
| RB | Dalvin Cook | Min | 5.40 | 13.69 | 219.10 | 27 Rush, 17 Receiving, 2 Rec |
| RB | Austin Ekeler | LAC | 30.10 | 19.64 | 314.20 | 122 Rush, 39 Receiving, 4 Rec, 2 TD |
| WR | Davante Adams | LV | 30.80 | 17.23 | 275.70 | 153 Receiving, 7 Rec, 2 TD |
| WR | Mike Evans | TB | 43.70 | 12.46 | 186.90 | 207 Receiving, 10 Rec, 3 TD |
| WR | CeeDee Lamb | Dal | 15.50 | 14.65 | 234.40 | 100 Receiving, 11 Rec |
| TE | Pat Freiermuth | Pit | 5.10 | 7.78 | 116.70 | 36 Receiving, 3 Rec |
| HB | Jaylen Waddle | Mia | 6.70 | 13.43 | 214.90 | 52 Receiving, 3 Rec |
| PK | Brett Maher | Dal | 10.00 | 10.00 | 160.00 | 1 FG(<40), 1 FG(40-49), 3 XP |
| DL | Javon Hargrave | Phi | 12.00 | 7.00 | 112.00 | 4 Tackles, 4 Assists, 1.0 Sack |
| DL | Sebastian Joseph-Day | LAC | 8.00 | 4.27 | 64.00 | 2 Tackles, 2 Assists, 1.0 Sack |
| DL | Ed Oliver | Buf | DNP | 4.50 | 54.00 | Did Not Play |
| LB | Josey Jewell | Den | 8.00 | 12.83 | 154.00 | 4 Tackles, 3 Assists, 1 PD |
| LB | Chris Kirksey | Hou | 6.00 | 8.88 | 142.00 | 2 Tackles, 4 Assists |
| LB | Germaine Pratt | Cin | DNP | 8.86 | 124.00 | Did Not Play |
| CB | Taron Johnson | Buf | DNP | 6.60 | 99.00 | Did Not Play |
| S | Jalen Pitre | Hou | 19.00 | 11.25 | 180.00 | 11 Tackles, 2 Assists, 1 Int, 1 PD |
| Pos. | 1st Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Kyler Murray | Ari | DNP | 20.96 | 230.52 | Did Not Play |
| RB | Latavius Murray | Den | 0(9.20) | 8.74 | 122.40 | 56 Rush, 16 Receiving, 4 Rec |
| WR | Donovan Peoples-Jones | Cle | 0(7.80) | 8.27 | 132.40 | 13 Receiving, 1 Rec, 1 TD |
| TE | Noah Fant | Sea | 0(5.00) | 5.85 | 93.60 | 40 Receiving, 2 Rec |
| WR | Mike Williams | LAC | 0(12.90) | 11.65 | 139.80 | 94 Receiving, 7 Rec |
| PK | Wil Lutz | NO | 0(10.00) | 7.00 | 112.00 | 1 FG(<40), 1 FG(50-59), 2 XP |
| DL | Chris Wormley | Pit | DNP | 2.77 | 36.00 | Did Not Play |
| LB | Demario Davis | NO | 8.00 | 9.06 | 145.00 | 3 Tackles, 4 Assists, 1 PD |
| Pos. | 2nd Backup | Proteam | TW | PPG | Total | Breakdown |
| RB | Kareem Hunt | Cle | 0(0.40) | 6.56 | 105.00 | - 1 Receiving, 1 Rec |
| WR | Terrace Marshall Jr. | Car | 0(2.50) | 5.05 | 65.70 | 15 Receiving, 2 Rec |
| WR | Mack Hollins | LV | 0(5.50) | 7.70 | 123.16 | 40 Receiving, 3 Rec |
| DL | Jadeveon Clowney | Cle | 5.00 | 3.75 | 45.00 | 3 Tackles, 2 Assists |
| LB | Kyzir White | Phi | 0(7.00) | 6.56 | 105.00 | 4 Tackles, 3 Assists |
| Offense = 152.38 Defense = 66 Total = 218.38 | ||||||
| Pos. | Bench | Proteam | TW | PPG | Total | Breakdown |
| QB | Derek Carr | LV | DNP | 17.81 | 267.08 | Did Not Play |
| RB | Damien Harris | NE | 6.50 | 7.68 | 76.80 | 32 Rush, 18 Receiving, 3 Rec |
| RB | Alexander Mattison | Min | 5.00 | 3.90 | 62.40 | 38 Rush, 7 Receiving, 1 Rec |
| Pos. | Injured List | Proteam | TW | PPG | Total | Breakdown |
| WR | Allen Robinson | LAR | DNP | 6.91 | 69.10 | Did Not Play |