| Pos. | Starters | Proteam | TW | PPG | Total | Breakdown |
| QB | Justin Fields | Chi | 26.72 | 21.36 | 192.20 | 223 Pass, 58 Rush, 2 TD |
| RB | Jerome Ford | Cle | 10.70 | 11.15 | 145.00 | 51 Rush, 31 Receiving, 5 Rec |
| RB | Keaton Mitchell | Bal | 6.70 | 7.94 | 55.60 | 54 Rush, 8 Receiving, 1 Rec |
| WR | Jayden Reed | GB | 16.50 | 10.30 | 133.90 | 38 Rush, 27 Receiving, 8 Rec, 1 TD |
| WR | Gabriel Davis | Buf | 0.00 | 8.91 | 115.80 | Played, No Stats |
| WR | Jaylen Waddle | Mia | 10.90 | 11.06 | 132.70 | 79 Receiving, 6 Rec |
| TE | Dalton Kincaid | Buf | 4.60 | 7.58 | 91.00 | 21 Receiving, 5 Rec |
| HB | George Pickens | Pit | 4.40 | 9.28 | 120.70 | 19 Receiving, 5 Rec |
| PK | Dustin Hopkins | Cle | 9.00 | 10.54 | 137.00 | 1 FG(50-59), 4 XP |
| DL | Ed Oliver | Buf | 6.00 | 5.83 | 70.00 | 1 Tackle, 2 Assists, 0.5 Sack, 1 PD |
| DL | Harrison Phillips | Min | 8.00 | 6.31 | 82.00 | 3 Tackles, 1 Assist, 1.0 Sack |
| DL | Josh Sweat | Phi | 3.00 | 5.23 | 68.00 | 3 Tackles |
| LB | Foyesade Oluokun | Jac | 7.00 | 13.62 | 177.00 | 5 Tackles, 2 Assists |
| LB | Tremaine Edmunds | Chi | 13.00 | 10.18 | 112.00 | 4 Tackles, 3 Assists, 1 Int, 1 PD |
| LB | Devin Lloyd | Jac | 14.00 | 10.27 | 113.00 | 4 Tackles, 7 Assists, 1 Fum Rcvy |
| CB | Brandon Stephens | Bal | 6.00 | 6.08 | 79.00 | 5 Tackles, 1 Assist |
| S | Antoine Winfield | TB | 15.00 | 11.92 | 155.00 | 4 Tackles, 4 Assists, 1.0 Sack, 1 FF |
| Pos. | 1st Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Aidan O'Connell | LV | 0(5.04) | 9.96 | 69.70 | 171 Pass, 2 Rush, 1 Int |
| RB | Salvon Ahmed | Mia | DNP | 4.36 | 34.90 | Did Not Play |
| WR | Terry McLaurin | Was | DNP | 9.03 | 117.40 | Team had a Bye |
| WR | Tank Dell | Hou | DNP | 12.86 | 141.50 | Did Not Play |
| DL | Chris Jones | KC | 0 | 4.75 | 57.00 | Played, No Stats |
| LB | Cody Barton | Was | DNP | 8.78 | 79.00 | Team had a Bye |
| CB | Cam Taylor-Britt | Cin | DNP | 7.73 | 85.00 | Did Not Play |
| S | Reed Blankenship | Phi | 0(3.00) | 9.64 | 106.00 | 3 Tackles |
| Pos. | 2nd Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Mac Jones | NE | DNP | 10.70 | 128.40 | Did Not Play |
| RB | Keaontay Ingram | KC | DNP | 1.50 | 12.00 | Did Not Play |
| WR | Khalil Shakir | Buf | 0(1.70) | 5.17 | 67.20 | 12 Receiving, 1 Rec |
| DL | Charles Omenihu | KC | 0(7.00) | 4.71 | 33.00 | 2 Tackles, 1 Assist, 1.0 Sack |
| LB | Jerome Baker | Mia | 0 | 7.15 | 93.00 | Played, No Stats |
| Offense = 89.52 Defense = 72 Total = 161.52 | ||||||
| Pos. | Bench | Proteam | TW | PPG | Total | Breakdown |
| RB | Cam Akers | Min | DNP | 5.89 | 41.20 | Did Not Play |
| RB | Michael Carter | Ari | DNP | 2.36 | 26.00 | Team had a Bye |
| WR | Jalen Guyton | LAC | 1.30 | 3.06 | 15.30 | 8 Receiving, 1 Rec |
| Pos. | Injured List | Proteam | TW | PPG | Total | Breakdown |
| RB | Nick Chubb | Cle | DNP | 10.55 | 21.10 | Did Not Play |