| Pos. | Starters | Proteam | TW | PPG | Total | Breakdown |
| QB | Derek Carr | NO | 26.32 | 14.89 | 208.42 | 218 Pass, -4 Rush, 3 TD |
| RB | Austin Ekeler | LAC | 5.80 | 12.81 | 140.90 | 9 Rush, 29 Receiving, 4 Rec |
| RB | David Montgomery | Det | 9.20 | 14.89 | 163.80 | 85 Rush, -3 Receiving, 2 Rec |
| WR | Marquise Brown | Ari | 0.00 | 7.80 | 109.20 | Played, No Stats |
| WR | Tyreek Hill | Mia | DNP | 21.17 | 275.20 | Did Not Play |
| WR | Parker Washington | Jac | 3.20 | 1.98 | 11.90 | 12 Receiving, 4 Rec |
| TE | Michael Mayer | LV | 11.90 | 4.14 | 57.90 | 39 Receiving, 4 Rec, 1 TD |
| HB | Saquon Barkley | NYG | 4.70 | 14.25 | 156.80 | 14 Rush, 23 Receiving, 2 Rec |
| PK | Dustin Hopkins | Cle | 8.00 | 10.36 | 145.00 | 2 FG(<40), 2 XP |
| DL | Carl Granderson | NO | 7.00 | 7.36 | 103.00 | 2 Tackles, 1 Assist, 1.0 Sack |
| DL | Sam Hubbard | Cin | 3.00 | 6.17 | 74.00 | 3 Tackles |
| DL | George Karlaftis | KC | 1.00 | 5.93 | 83.00 | 1 Tackle |
| LB | Lavonte David | TB | 12.00 | 10.58 | 127.00 | 7 Tackles, 2 Assists, 0.5 Sack, 1 PD |
| LB | T.J. Edwards | Chi | 10.00 | 12.21 | 171.00 | 1 Tackle, 5 Assists, 0.5 Sack, 2 PD |
| LB | Bobby Okereke | NYG | 3.00 | 10.86 | 152.00 | 2 Tackles, 1 Assist |
| CB | Tyrique Stevenson | Chi | 12.00 | 7.15 | 93.00 | 4 Tackles, 1 Assist, 1 Int, 2 PD |
| S | Jessie Bates | Atl | 10.00 | 11.43 | 160.00 | 6 Tackles, 4 Assists |
| Pos. | 1st Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Desmond Ridder | Atl | 0(9.88) | 14.49 | 188.32 | 152 Pass, -2 Rush, 1 TD, 1 Int |
| RB | Keaton Mitchell | Bal | 0(9.80) | 8.18 | 65.40 | 73 Rush, 15 Receiving, 2 Rec |
| WR | Michael Gallup | Dal | 1.40 | 4.96 | 69.40 | 9 Receiving, 1 Rec |
| RB | James Conner | Ari | 0(16.40) | 11.41 | 114.10 | 86 Rush, 3 Receiving, 3 Rec, 1 TD |
| DL | Aaron Donald | LAR | 0(3.00) | 5.07 | 71.00 | 1 Tackle, 2 Assists |
| LB | Josey Jewell | Den | 0(9.00) | 8.46 | 110.00 | 7 Tackles, 2 Assists |
| Pos. | 2nd Backup | Proteam | TW | PPG | Total | Breakdown |
| WR | Demario Douglas | NE | 0(4.80) | 5.97 | 65.70 | 33 Receiving, 3 Rec |
| Offense = 70.52 Defense = 58 Total = 128.52 | ||||||
| Pos. | Bench | Proteam | TW | PPG | Total | Breakdown |
| QB | Joshua Dobbs | Min | 0.00 | 16.69 | 233.66 | Played, No Stats |
| QB | Justin Herbert | LAC | DNP | 21.13 | 274.72 | Did Not Play |
| RB | Clyde Edwards-Helaire | KC | 18.10 | 4.14 | 53.80 | 37 Rush, 64 Receiving, 4 Rec, 1 TD |
| RB | Kendre Miller | NO | DNP | 3.41 | 23.90 | Did Not Play |
| RB | Latavius Murray | Buf | 7.10 | 5.31 | 74.40 | 11 Rush, 1 TD |
| RB | Chris Rodriguez | Was | 3.50 | 1.58 | 18.90 | 35 Rush |
| WR | Keenan Allen | LAC | DNP | 17.51 | 227.66 | Did Not Play |
| TE | Tyler Higbee | LAR | 5.60 | 5.48 | 71.30 | 36 Receiving, 4 Rec |
| LB | Micah McFadden | NYG | 6.00 | 8.15 | 106.00 | 5 Tackles, 1 Assist |
| Pos. | Injured List | Proteam | TW | PPG | Total | Breakdown |
| WR | Mike Williams | LAC | DNP | 13.57 | 40.70 | Did Not Play |