| Pos. | Starters | Proteam | TW | PPG | Total | Breakdown |
| QB | Justin Herbert | LAC | 20.68 | 19.40 | 310.44 | 212 Pass, 2 Rush, 2 TD |
| RB | Austin Ekeler | LAC | 30.10 | 19.64 | 314.20 | 122 Rush, 39 Receiving, 4 Rec, 2 TD |
| RB | David Montgomery | Chi | 4.60 | 10.71 | 160.60 | 24 Rush, 12 Receiving, 2 Rec |
| WR | Keenan Allen | LAC | 9.30 | 11.76 | 105.80 | 8 Rush, 60 Receiving, 5 Rec |
| WR | Tyreek Hill | Mia | 13.70 | 17.77 | 284.40 | 2 Rush, 55 Receiving, 4 Rec, 1 TD |
| WR | Rashid Shaheed | NO | 10.90 | 7.35 | 80.90 | 79 Receiving, 6 Rec |
| TE | Travis Kelce | KC | 7.80 | 15.97 | 255.50 | 43 Receiving, 7 Rec |
| HB | James Conner | Ari | 12.50 | 13.71 | 178.20 | 79 Rush, 31 Receiving, 3 Rec |
| PK | Ka'imi Fairbairn | Hou | 5.00 | 7.81 | 125.00 | 1 FG(50-59) |
| DL | Jonathan Allen | Was | 0.00 | 6.25 | 100.00 | Played, No Stats |
| DL | Kwity Paye | Ind | 2.00 | 6.36 | 70.00 | 1 Tackle, 1 Assist |
| DL | Greg Rousseau | Buf | DNP | 5.58 | 67.00 | Did Not Play |
| LB | Ja'Whaun Bentley | NE | 9.00 | 8.44 | 135.00 | 5 Tackles, 4 Assists |
| LB | Josey Jewell | Den | 8.00 | 12.83 | 154.00 | 4 Tackles, 3 Assists, 1 PD |
| LB | Chris Kirksey | Hou | 6.00 | 8.88 | 142.00 | 2 Tackles, 4 Assists |
| CB | Jeff Okudah | Det | 1.00 | 6.27 | 94.00 | 1 Assist |
| S | Jaquan Brisker | Chi | 8.00 | 8.64 | 121.00 | 6 Tackles, 2 Assists |
| Pos. | 1st Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Geno Smith | Sea | 0(21.12) | 22.02 | 352.26 | 183 Pass, 18 Rush, 2 TD |
| RB | Raheem Mostert | Mia | 0(19.10) | 9.78 | 146.70 | 29 Rush, 62 Receiving, 8 Rec, 1 TD |
| WR | Isaiah Hodgins | NYG | 0(12.20) | 4.52 | 67.80 | 42 Receiving, 4 Rec, 1 TD |
| TE | Isaiah Likely | Bal | 0(8.70) | 3.93 | 59.00 | 12 Receiving, 3 Rec, 1 TD |
| WR | Julio Jones | TB | 0(2.80) | 5.84 | 58.40 | 13 Rush, 10 Receiving, 1 Rec |
| DL | George Karlaftis | KC | 9.00 | 3.81 | 61.00 | 1 Tackle, 1 Assist, 1.0 Sack, 1 Fum Rcvy |
| LB | Shaq Thompson | Car | 0(12.00) | 8.56 | 137.00 | 5 Tackles, 7 Assists |
| CB | Camryn Bynum | Min | 0(9.00) | 6.13 | 98.00 | 4 Tackles, 5 Assists |
| Offense = 114.58 Defense = 43 Total = 157.58 | ||||||
| Pos. | Bench | Proteam | TW | PPG | Total | Breakdown |
| RB | Marlon Mack | Den | 0.00 | 4.29 | 34.30 | Played, No Stats |
| RB | Latavius Murray | Den | 9.20 | 8.74 | 122.40 | 56 Rush, 16 Receiving, 4 Rec |
| RB | Isaiah Spiller | LAC | DNP | 1.15 | 6.90 | Did Not Play |
| RB | Jeff Wilson | Mia | 9.10 | 9.41 | 141.10 | 45 Rush, 31 Receiving, 3 Rec |
| WR | Romeo Doubs | GB | 3.50 | 6.80 | 81.60 | 20 Receiving, 3 Rec |
| WR | Rondale Moore | Ari | DNP | 8.43 | 67.40 | Did Not Play |
| WR | Amari Rodgers | Hou | 2.60 | 1.73 | 29.40 | 4 Rush, 12 Receiving, 2 Rec |
| LB | Kaden Elliss | NO | 14.00 | 7.00 | 112.00 | 4 Tackles, 1 Assist, 1.5 Sacks, 1 FF |