| Pos. | Starters | Proteam | TW | PPG | Total | Breakdown |
| QB | Teddy Bridgewater | Mia | 11.04 | 9.20 | 46.02 | 161 Pass, 6 Rush, 1 TD, 1 Int |
| RB | Joe Mixon | Cin | DNP | 14.94 | 194.20 | Did Not Play |
| RB | Brian Robinson | Was | 8.70 | 9.02 | 108.20 | 87 Rush |
| WR | Justin Jefferson | Min | 2.00 | 18.68 | 298.86 | 15 Receiving, 1 Rec |
| WR | D.J. Moore | Car | 20.60 | 10.38 | 166.00 | - 1 Rush, 117 Receiving, 6 Rec, 1 TD |
| WR | JuJu Smith-Schuster | KC | 3.10 | 9.59 | 143.80 | 21 Receiving, 2 Rec |
| TE | Travis Kelce | KC | 7.80 | 15.97 | 255.50 | 43 Receiving, 7 Rec |
| HB | Chris Olave | NO | 6.20 | 10.76 | 150.70 | 42 Receiving, 4 Rec |
| PK | Michael Badgley | Det | 12.00 | 8.73 | 96.00 | 1 FG(<40), 1 FG(40-49), 5 XP |
| DL | Maxx Crosby | LV | 2.00 | 9.06 | 145.00 | 2 Tackles |
| DL | Josh Sweat | Phi | 1.00 | 6.63 | 106.00 | 1 Assist |
| DL | Dalvin Tomlinson | Min | 8.00 | 4.83 | 58.00 | 2 Tackles, 2 Assists, 1.0 Sack |
| LB | Zaire Franklin | Ind | 12.00 | 11.19 | 179.00 | 7 Tackles, 3 Assists, 2 PD |
| LB | Drue Tranquill | LAC | 9.00 | 10.75 | 172.00 | 6 Tackles, 3 Assists |
| LB | T.J. Watt | Pit | 8.00 | 8.22 | 74.00 | 3 Tackles, 1 Assist, 1.0 Sack |
| CB | Tyson Campbell | Jac | 12.00 | 6.44 | 103.00 | 2 Tackles, 1 Assist, 1 TD, 1 Fum Rcvy |
| S | L'Jarius Sneed | KC | 8.00 | 9.75 | 156.00 | 2 Tackles, 1 Int, 1 PD |
| Pos. | 1st Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Russell Wilson | Den | 0(26.58) | 16.44 | 230.14 | 222 Pass, 27 Rush, 3 TD, 1 Int, 1 Fumb |
| RB | Samaje Perine | Cin | DNP | 8.03 | 120.40 | Did Not Play |
| WR | Josh Palmer | LAC | 0 | 8.36 | 125.40 | Played, No Stats |
| RB | Chuba Hubbard | Car | 0(8.00) | 5.34 | 74.80 | 12 Rush, 53 Receiving, 3 Rec |
| PK | Jason Sanders | Mia | 0(3.00) | 7.50 | 120.00 | 3 XP |
| DL | Justin Jones | Chi | 0(10.00) | 4.25 | 68.00 | 3 Tackles, 3 Assists, 1.0 Sack |
| LB | Tremaine Edmunds | Buf | DNP | 8.75 | 105.00 | Did Not Play |
| Pos. | 2nd Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Carson Wentz | Was | 0(6.42) | 16.98 | 135.80 | 143 Pass, 7 Rush, 1 TD, 3 Int |
| RB | Deon Jackson | Ind | 1.00 | 3.77 | 56.50 | 10 Rush |
| RB | Raheem Blackshear | Car | 0(0.40) | 2.44 | 39.00 | - 1 Receiving, 1 Rec |
| Offense = 72.44 Defense = 60 Total = 132.44 | ||||||
| Pos. | Bench | Proteam | TW | PPG | Total | Breakdown |
| QB | Taylor Heinicke | Was | DNP | 16.11 | 144.96 | Did Not Play |
| RB | Tony Pollard | Dal | DNP | 15.16 | 227.40 | Did Not Play |
| RB | Jonathan Taylor | Ind | DNP | 12.31 | 135.40 | Did Not Play |
| RB | Jaylen Warren | Pit | 11.30 | 4.90 | 73.50 | 76 Rush, 22 Receiving, 3 Rec |
| RB | Kyren Williams | LAR | 0.60 | 2.89 | 26.00 | 6 Rush |
| TE | Greg Dulcich | Den | 0.00 | 6.33 | 69.60 | Played, No Stats |
| Pos. | Injured List | Proteam | TW | PPG | Total | Breakdown |
| QB | Kyler Murray | Ari | DNP | 20.96 | 230.52 | Did Not Play |