| Pos. | Starters | Proteam | TW | PPG | Total | Breakdown |
| QB | Jalen Hurts | Phi | 25.18 | 25.45 | 407.22 | 167 Pass, 25 Rush, 3 TD, 1 Int |
| RB | Saquon Barkley | NYG | 7.30 | 14.00 | 182.00 | 39 Rush, 19 Receiving, 3 Rec |
| RB | James Cook | Buf | 4.90 | 12.88 | 206.00 | 48 Rush, -4 Receiving, 1 Rec |
| WR | CeeDee Lamb | Dal | 34.70 | 19.29 | 308.70 | 5 Rush, 227 Receiving, 13 Rec, 1 TD, 1 Fumb |
| WR | Puka Nacua | LAR | 16.20 | 14.62 | 233.90 | 19 Rush, 118 Receiving, 5 Rec |
| WR | Jaxon Smith-Njigba | Sea | 7.70 | 7.21 | 115.40 | 12 Receiving, 1 Rec, 1 TD |
| TE | Sam LaPorta | Det | 11.90 | 11.56 | 184.90 | 84 Receiving, 7 Rec |
| HB | Javonte Williams | Den | 7.30 | 9.31 | 139.70 | 41 Rush, 17 Receiving, 3 Rec |
| PK | Tyler Bass | Buf | 9.00 | 8.00 | 128.00 | 2 FG(<40), 3 XP |
| DL | Nick Bosa | SF | 4.00 | 6.50 | 104.00 | 2 Tackles, 1 Assist, 1 PD |
| DL | Micah Parsons | Dal | 6.00 | 7.44 | 119.00 | 5 Tackles, 1 Assist |
| DL | Kayvon Thibodeaux | NYG | 2.00 | 6.75 | 108.00 | 2 Assists |
| LB | Terrel Bernard | Buf | 18.00 | 11.81 | 189.00 | 8 Tackles, 2 Assists, 2.0 Sacks |
| LB | Khaleke Hudson | Was | 11.00 | 4.25 | 68.00 | 4 Tackles, 7 Assists |
| LB | Quay Walker | GB | 10.00 | 9.92 | 129.00 | 2 Tackles, 4 Assists, 1.0 Sack |
| CB | Jason Pinnock | NYG | 2.00 | 7.56 | 121.00 | 2 Assists |
| S | Kamren Curl | Was | 9.00 | 8.19 | 131.00 | 6 Tackles, 3 Assists |
| Pos. | 1st Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Josh Allen | Buf | 0(21.16) | 26.66 | 426.58 | 169 Pass, 44 Rush, 2 TD, 1 Int |
| RB | Kenneth Gainwell | Phi | 0(4.68) | 5.15 | 77.18 | 17 Pass, 5 Rush, 15 Receiving, 4 Rec |
| WR | Romeo Doubs | GB | 0(4.30) | 9.06 | 144.90 | 28 Receiving, 3 Rec |
| TE | Jake Ferguson | Dal | 0(5.30) | 8.23 | 131.70 | 33 Receiving, 4 Rec |
| RB | Chase Brown | Cin | 0(3.80) | 3.70 | 40.70 | 5 Rush, 23 Receiving, 2 Rec |
| LB | E.J. Speed | Ind | 0(12.00) | 7.13 | 107.00 | 8 Tackles, 4 Assists |
| CB | Devon Witherspoon | Sea | 0(3.00) | 8.46 | 110.00 | 3 Tackles |
| S | Dax Hill | Cin | 0(6.00) | 8.13 | 130.00 | 5 Tackles, 1 Assist |
| Pos. | 2nd Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Gardner Minshew | Ind | 0(15.26) | 13.79 | 220.66 | 224 Pass, 3 Rush, 1 TD |
| WR | Jalin Hyatt | NYG | 0(4.00) | 2.99 | 47.80 | 25 Receiving, 3 Rec |
| WR | Kadarius Toney | KC | DNP | 3.04 | 39.50 | Did Not Play |
| LB | Divine Deablo | LV | 0(3.00) | 7.50 | 105.00 | 2 Tackles, 1 Assist |
| Offense = 124.18 Defense = 62 Total = 186.18 | ||||||
| Pos. | Bench | Proteam | TW | PPG | Total | Breakdown |
| RB | Leonard Fournette | Buf | DNP | 0.00 | 0.00 | Did Not Play |
| LB | Kaden Elliss | Atl | 13.00 | 8.63 | 138.00 | 6 Tackles, 3 Assists, 1.0 Sack |
| LB | Isaiah McDuffie | GB | 6.00 | 5.93 | 89.00 | 1 Tackle, 2 Assists, 0.5 Sack, 1 PD |
| S | Ji'Ayir Brown | SF | DNP | 0.00 | 0.00 | Did Not Play |
| Pos. | Injured List | Proteam | TW | PPG | Total | Breakdown |
| TE | Luke Musgrave | GB | DNP | 5.66 | 56.60 | Did Not Play |