| Pos. | Starters | Proteam | TW | PPG | Total | Breakdown |
| QB | Jake Browning | Cin | 24.04 | 15.27 | 167.94 | 156 Pass, 18 Rush, 3 TD, 1 Int |
| RB | James Conner | Ari | 28.40 | 14.46 | 188.00 | 150 Rush, 54 Receiving, 4 Rec, 1 TD |
| RB | Isiah Pacheco | KC | 0.00 | 12.86 | 192.90 | Played, No Stats |
| WR | Ja'Marr Chase | Cin | 3.90 | 13.30 | 212.72 | 19 Receiving, 4 Rec |
| WR | Stefon Diggs | Buf | 12.20 | 13.02 | 221.30 | 87 Receiving, 7 Rec |
| WR | Adam Thielen | Car | 2.20 | 10.56 | 179.50 | 12 Receiving, 2 Rec |
| TE | Jonnu Smith | Atl | 10.40 | 5.89 | 100.20 | 29 Receiving, 3 Rec, 1 TD |
| HB | Kyren Williams | LAR | DNP | 20.08 | 241.00 | Did Not Play |
| PK | Jake Elliott | Phi | 4.00 | 9.12 | 155.00 | 1 FG(<40), 1 XP |
| DL | Aidan Hutchinson | Det | 12.00 | 7.29 | 124.00 | 4 Tackles, 2.0 Sacks |
| DL | Harold Landry | Ten | 0.00 | 6.53 | 111.00 | Played, No Stats |
| DL | Montez Sweat | Chi | 3.00 | 7.00 | 119.00 | 2 Tackles, 1 Assist |
| LB | De'Vondre Campbell | GB | 8.00 | 7.18 | 79.00 | 4 Tackles, 4 Assists |
| LB | Frankie Luvu | Car | 9.00 | 9.53 | 162.00 | 3 Tackles, 3 Assists, 1 FF |
| LB | C.J. Mosley | NYJ | 7.00 | 10.24 | 174.00 | 3 Tackles, 4 Assists |
| CB | Charvarius Ward | SF | 4.00 | 7.59 | 129.00 | 4 Tackles |
| S | Antoine Winfield | TB | 12.00 | 11.76 | 200.00 | 4 Tackles, 1 Assist, 1.0 Sack, 1 FF |
| Pos. | 1st Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Desmond Ridder | Atl | 0(20.64) | 12.98 | 207.64 | 291 Pass, 2 TD, 1 Int, 1 Fumb |
| RB | Emari Demercado | Ari | 0 | 4.49 | 62.80 | Played, No Stats |
| WR | Jameson Williams | Det | DNP | 5.69 | 68.30 | Did Not Play |
| TE | Tyler Higbee | LAR | DNP | 5.67 | 85.00 | Did Not Play |
| WR | Diontae Johnson | Pit | 16.90 | 9.09 | 127.20 | 89 Receiving, 4 Rec, 1 TD |
| DL | Denico Autry | Ten | 0(1.00) | 6.06 | 103.00 | 1 Assist |
| LB | Shaquille Leonard | Phi | 0(5.00) | 6.57 | 92.00 | 3 Tackles, 2 Assists |
| CB | L'Jarius Sneed | KC | DNP | 6.69 | 107.00 | Did Not Play |
| S | Xavier McKinney | NYG | 0(19.00) | 8.94 | 152.00 | 2 Tackles, 4 Assists, 2 Int, 3 PD |
| Pos. | 2nd Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Matthew Stafford | LAR | DNP | 19.41 | 291.10 | Did Not Play |
| WR | Josh Reynolds | Det | 0(6.90) | 6.46 | 109.80 | 44 Receiving, 5 Rec |
| LB | Micah McFadden | NYG | 0(14.00) | 7.94 | 127.00 | 7 Tackles, 2 Assists, 1 Fum Rcvy, 2 PD |
| Offense = 102.04 Defense = 55 Total = 157.04 | ||||||
| Pos. | Bench | Proteam | TW | PPG | Total | Breakdown |
| RB | Christian McCaffrey | SF | DNP | 22.49 | 359.80 | Did Not Play |
| RB | Keaton Mitchell | Bal | DNP | 8.18 | 65.40 | Did Not Play |
| WR | Marquise Brown | Ari | DNP | 7.80 | 109.20 | Did Not Play |
| TE | Mark Andrews | Bal | DNP | 11.29 | 112.90 | Did Not Play |
| Pos. | Injured List | Proteam | TW | PPG | Total | Breakdown |
| QB | Joe Burrow | Cin | DNP | 17.82 | 178.16 | Did Not Play |