| Pos. | Starters | Proteam | TW | PPG | Total | Breakdown |
| QB | Baker Mayfield | TB | 20.26 | 20.43 | 326.88 | 309 Pass, -1 Rush, 2 TD, 2 Int |
| RB | Ty Chandler | Min | 7.90 | 5.04 | 80.60 | 40 Rush, 24 Receiving, 3 Rec |
| RB | Christian McCaffrey | SF | 11.10 | 22.49 | 359.80 | 64 Rush, 27 Receiving, 4 Rec |
| WR | Stefon Diggs | Buf | 5.10 | 13.07 | 209.10 | 5 Rush, 26 Receiving, 4 Rec |
| WR | Tee Higgins | Cin | 2.40 | 9.72 | 116.60 | 19 Receiving, 1 Rec |
| WR | Justin Jefferson | Min | 8.40 | 15.47 | 139.20 | 59 Receiving, 5 Rec |
| TE | Travis Kelce | KC | 3.10 | 11.59 | 173.90 | 16 Receiving, 3 Rec |
| HB | Aaron Jones | GB | 13.50 | 10.43 | 104.30 | 120 Rush, 10 Receiving, 1 Rec |
| PK | Jason Sanders | Mia | 7.00 | 8.94 | 143.00 | 2 FG(<40), 1 XP |
| DL | Maxx Crosby | LV | 9.00 | 9.56 | 153.00 | 3 Tackles, 3 Assists, 1 FF |
| DL | Andrew Van Ginkel | Mia | 3.00 | 7.13 | 114.00 | 1 Tackle, 2 Assists |
| DL | T.J. Watt | Pit | 2.00 | 10.50 | 168.00 | 1 Tackle, 1 Assist |
| LB | Alex Anzalone | Det | 8.00 | 9.33 | 140.00 | 5 Tackles, 3 Assists |
| LB | Alex Singleton | Den | 11.00 | 11.38 | 182.00 | 7 Tackles, 4 Assists |
| LB | Robert Spillane | LV | 6.00 | 10.94 | 175.00 | 5 Tackles, 1 Assist |
| CB | L'Jarius Sneed | KC | 4.00 | 6.69 | 107.00 | 2 Tackles, 1 Assist, 1 PD |
| S | Reed Blankenship | Phi | 11.00 | 9.21 | 129.00 | 7 Tackles, 4 Assists |
| Pos. | 1st Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Mitchell Trubisky | Pit | 0 | 5.24 | 57.68 | Played, No Stats |
| RB | Alexander Mattison | Min | 0(4.00) | 7.79 | 116.80 | 17 Rush, 13 Receiving, 2 Rec |
| WR | Jakobi Meyers | LV | 0(8.60) | 11.00 | 164.98 | 56 Receiving, 6 Rec |
| TE | Gerald Everett | LAC | 0(5.70) | 6.05 | 84.70 | 6 Rush, 31 Receiving, 4 Rec |
| RB | Kareem Hunt | Cle | 0(9.10) | 7.86 | 110.00 | 31 Rush, 1 TD |
| DL | Michael Danna | KC | 0(2.00) | 4.94 | 79.00 | 2 Tackles |
| S | Markquese Bell | Dal | 0(10.00) | 6.31 | 101.00 | 8 Tackles, 2 Assists |
| Pos. | 2nd Backup | Proteam | TW | PPG | Total | Breakdown |
| RB | Jeff Wilson | Mia | 0(4.90) | 3.31 | 29.80 | 21 Rush, 13 Receiving, 3 Rec |
| LB | Sione Takitaki | Cle | 0(17.00) | 5.40 | 81.00 | 11 Tackles, 5 Assists, 1 PD |
| Offense = 78.76 Defense = 54 Total = 132.76 | ||||||
| Pos. | Bench | Proteam | TW | PPG | Total | Breakdown |
| QB | Kenny Pickett | Pit | DNP | 10.18 | 122.20 | Did Not Play |
| QB | Mason Rudolph | Pit | 11.46 | 7.12 | 35.58 | 274 Pass, 5 Rush |
| RB | Trayveon Williams | Cin | 0.20 | 0.73 | 11.00 | 2 Rush |
| WR | DJ Chark | Car | 2.30 | 6.74 | 94.40 | 18 Receiving, 1 Rec |
| WR | Rondale Moore | Ari | 4.90 | 4.96 | 79.40 | 8 Rush, 26 Receiving, 3 Rec |
| WR | Darius Slayton | NYG | 18.60 | 6.96 | 111.30 | 106 Receiving, 4 Rec, 1 TD |
| WR | Marquez Valdes-Scantling | KC | 0.80 | 2.94 | 47.00 | 3 Receiving, 1 Rec |