| Pos. | Starters | Proteam | TW | PPG | Total | Breakdown |
| QB | Matthew Stafford | LAR | 22.52 | 19.37 | 251.80 | 258 Pass, 2 Rush, 2 TD |
| RB | Jahmyr Gibbs | Det | 23.80 | 15.02 | 180.30 | 100 Rush, 8 Receiving, 2 Rec, 2 TD |
| RB | Alvin Kamara | NO | 13.50 | 16.69 | 183.60 | 66 Rush, 44 Receiving, 5 Rec |
| WR | Cooper Kupp | LAR | 21.10 | 11.63 | 116.30 | 111 Receiving, 8 Rec, 1 TD |
| WR | Noah Brown | Hou | 18.20 | 9.81 | 78.50 | 82 Receiving, 8 Rec, 1 TD |
| WR | Courtland Sutton | Den | 9.60 | 11.64 | 163.00 | 71 Receiving, 5 Rec |
| TE | Tucker Kraft | GB | 13.70 | 3.04 | 42.60 | 57 Receiving, 4 Rec, 1 TD |
| HB | James Cook | Buf | 35.10 | 13.94 | 195.10 | 179 Rush, 42 Receiving, 2 Rec, 2 TD |
| PK | Dustin Hopkins | Cle | 8.00 | 10.36 | 145.00 | 2 FG(<40), 2 XP |
| DL | Danielle Hunter | Min | 13.00 | 10.21 | 143.00 | 3 Tackles, 2 Assists, 2.0 Sacks |
| DL | Haason Reddick | Phi | 2.00 | 0.00 | 0.00 | |
| DL | Michael Hoecht | LAR | 4.00 | 6.29 | 88.00 | 3 Tackles, 1 PD |
| LB | Foyesade Oluokun | Jac | 10.00 | 13.36 | 187.00 | 8 Tackles, 2 Assists |
| LB | Bobby Wagner | Sea | 11.00 | 0.00 | 0.00 | |
| LB | Roquan Smith | Bal | 6.00 | 11.21 | 157.00 | 4 Tackles, 2 Assists |
| CB | Trent McDuffie | KC | 1.00 | 7.29 | 102.00 | 1 Tackle |
| S | Ronnie Harrison | Ind | 0.00 | 5.00 | 10.00 | Played, No Stats |
| Pos. | 1st Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Russell Wilson | Den | 0(20.52) | 20.46 | 286.38 | 223 Pass, 6 Rush, 2 TD, 1 Fumb |
| RB | Tyjae Spears | Ten | 0(4.20) | 6.69 | 93.60 | 30 Rush, 7 Receiving, 1 Rec |
| WR | Jayden Reed | GB | 0(14.20) | 10.58 | 148.10 | 52 Receiving, 6 Rec, 1 TD |
| TE | Juwan Johnson | NO | 0(10.80) | 4.20 | 42.00 | 38 Receiving, 2 Rec, 1 TD |
| WR | Dontayvion Wicks | GB | 0(12.70) | 5.40 | 70.26 | 97 Receiving, 6 Rec |
| DL | Rashan Gary | GB | 0(1.00) | 6.07 | 85.00 | 1 Tackle |
| LB | Azeez Al-Shaair | Ten | 0(13.00) | 10.79 | 151.00 | 7 Tackles, 6 Assists |
| Pos. | 2nd Backup | Proteam | TW | PPG | Total | Breakdown |
| RB | Latavius Murray | Buf | 0(7.10) | 5.31 | 74.40 | 11 Rush, 1 TD |
| WR | Tutu Atwell | LAR | DNP | 6.89 | 89.60 | Did Not Play |
| TE | Cade Otton | TB | 0(5.40) | 6.20 | 86.80 | 44 Receiving, 2 Rec |
| DL | Alex Highsmith | Pit | 0(4.00) | 6.86 | 96.00 | 4 Tackles |
| LB | Byron Young | LAR | 0(3.00) | 6.07 | 85.00 | 1 Tackle, 2 Assists |
| Offense = 165.52 Defense = 47 Total = 212.52 | ||||||
| Pos. | Bench | Proteam | TW | PPG | Total | Breakdown |
| RB | Jaleel McLaughlin | Den | 2.80 | 5.25 | 73.50 | 2 Rush, 16 Receiving, 2 Rec |
| WR | Marvin Mims | Den | 1.10 | 4.19 | 58.70 | 11 Rush |
| WR | Josh Palmer | LAC | 19.30 | 9.19 | 73.50 | 113 Receiving, 4 Rec, 1 TD |
| WR | Jerry Jeudy | Den | 8.90 | 6.66 | 86.60 | 74 Receiving, 3 Rec |
| Pos. | Injured List | Proteam | TW | PPG | Total | Breakdown |
| TE | Mark Andrews | Bal | DNP | 11.29 | 112.90 | Did Not Play |