| Pos. | Starters | Proteam | TW | PPG | Total | Breakdown |
| QB | Derek Carr | NO | 14.76 | 14.01 | 182.10 | 119 Pass, 2 TD, 1 Int |
| RB | Samaje Perine | Den | 6.90 | 6.15 | 80.00 | 8 Rush, 36 Receiving, 5 Rec |
| RB | Gus Edwards | Bal | 1.50 | 10.81 | 140.50 | 15 Rush |
| WR | Keenan Allen | LAC | 9.80 | 17.51 | 227.66 | 68 Receiving, 6 Rec |
| WR | Chris Olave | NO | 10.80 | 11.68 | 151.80 | 28 Receiving, 4 Rec, 1 TD |
| WR | Rashee Rice | KC | 15.70 | 10.04 | 130.50 | 72 Receiving, 7 Rec, 1 TD, 1 Fumb |
| TE | George Kittle | SF | 15.10 | 11.06 | 143.80 | 76 Receiving, 3 Rec, 1 TD |
| HB | Jaylen Waddle | Mia | 10.90 | 11.06 | 132.70 | 79 Receiving, 6 Rec |
| PK | Dustin Hopkins | Cle | 9.00 | 10.54 | 137.00 | 1 FG(50-59), 4 XP |
| DL | Khalil Mack | LAC | 3.00 | 10.38 | 135.00 | 1 Tackle, 1 Assist, 1 PD |
| DL | Sheldon Rankins | Hou | 6.00 | 4.82 | 53.00 | 2 Tackles, 1.0 Sack |
| DL | Jonathan Greenard | Hou | 15.00 | 6.69 | 87.00 | 5 Tackles, 1 Assist, 2.0 Sacks, 1 PD |
| LB | Quay Walker | GB | DNP | 10.60 | 106.00 | Did Not Play |
| LB | Micah McFadden | NYG | 7.00 | 8.33 | 100.00 | 2 Tackles, 3 Assists, 0.5 Sack |
| LB | Elandon Roberts | Pit | 11.00 | 7.46 | 97.00 | 2 Tackles, 4 Assists, 1.0 Sack, 1 PD |
| CB | D.J. Reed | NYJ | 7.00 | 6.82 | 75.00 | 4 Tackles, 3 PD |
| S | Amani Hooker | Ten | 6.00 | 7.83 | 94.00 | 4 Tackles, 1 Assist, 1 PD |
| Pos. | 1st Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Desmond Ridder | Atl | 0(27.38) | 14.87 | 178.44 | 347 Pass, 15 Rush, 2 TD, 1 Int, 1 2-Pt |
| RB | D'Onta Foreman | Chi | 0(8.20) | 10.79 | 86.30 | 50 Rush, 22 Receiving, 2 Rec |
| WR | Zay Flowers | Bal | 0(17.00) | 10.07 | 130.90 | 60 Receiving, 6 Rec, 1 TD, 1 2-Pt |
| WR | Noah Brown | Hou | 0 | 8.61 | 60.30 | Played, No Stats |
| DL | Harrison Phillips | Min | 0(8.00) | 6.31 | 82.00 | 3 Tackles, 1 Assist, 1.0 Sack |
| LB | Ivan Pace | Min | 23.00 | 6.77 | 88.00 | 7 Tackles, 6 Assists, 1.0 Sack, 1 Int, 1 PD |
| Offense = 94.46 Defense = 78 Total = 172.46 | ||||||
| Pos. | Bench | Proteam | TW | PPG | Total | Breakdown |
| QB | Kyler Murray | Ari | DNP | 19.29 | 77.16 | Team had a Bye |
| RB | Dalvin Cook | NYJ | 1.30 | 2.55 | 33.20 | 13 Rush, -5 Receiving, 1 Rec |
| RB | Emari Demercado | Ari | DNP | 3.94 | 39.40 | Team had a Bye |
| RB | Chris Rodriguez | Was | DNP | 1.40 | 15.40 | Team had a Bye |
| RB | D'Ernest Johnson | Jac | 3.80 | 2.25 | 29.20 | 12 Rush, 16 Receiving, 2 Rec |
| WR | Romeo Doubs | GB | 5.20 | 9.25 | 120.20 | 32 Receiving, 4 Rec |
| WR | Jordan Addison | Min | 3.70 | 10.88 | 141.50 | 27 Receiving, 2 Rec |
| WR | Marvin Mims | Den | 2.10 | 4.43 | 57.60 | 11 Receiving, 2 Rec |
| WR | Brandin Cooks | Dal | 4.70 | 8.93 | 107.20 | 37 Receiving, 2 Rec |
| WR | Justin Watson | KC | 2.30 | 4.35 | 56.50 | 18 Receiving, 1 Rec |
| Pos. | Injured List | Proteam | TW | PPG | Total | Breakdown |
| WR | Michael Thomas | NO | DNP | 7.03 | 70.30 | Did Not Play |