| Position | Starters | Proteam | TW | PPG | Total | Breakdown |
|---|---|---|---|---|---|---|
| QB | Kyler Murray | Ari | 14.58 | 25.32 | 278.56 | 257 Pass, 3 Rush, 1 TD, 1 Int |
| RB | Clyde Edwards-Helaire | KC | 8.0 | 11.17 | 100.50 | 32 Rush, 18 Receiving, 2 Rec, 1 2-Pt |
| RB | Dontrell Hilliard | Ten | 7.9 | 8.04 | 40.20 | 49 Rush, 10 Receiving, 4 Rec |
| WR | Michael Gallup | Dal | 4.7 | 8.09 | 56.60 | 32 Receiving, 3 Rec |
| WR | Tim Patrick | Den | 11.7 | 8.19 | 114.60 | 42 Receiving, 3 Rec, 1 TD |
| WR | Hunter Renfrow | LV | 4.7 | 11.79 | 165.10 | 32 Receiving, 3 Rec |
| TE | George Kittle | SF | 12.3 | 13.90 | 152.90 | 93 Receiving, 6 Rec |
| HB (TE) | Dalton Schultz | Dal | 16.7 | 9.11 | 127.60 | 67 Receiving, 8 Rec, 1 TD |
| PK | Evan McPherson | Cin | 13.0 | 9.29 | 130.00 | 1 FG(<40), 2 FG(50-59) |
| DL | Jonathan Allen | Was | 11.0 | 6.14 | 86.00 | 5 Tackles, 2 Assists, 1.0 Sack |
| DL | Sam Hubbard | Cin | 1.0 | 6.64 | 93.00 | 1 Assist |
| DL | Linval Joseph | LAC | 3.0 | 4.82 | 53.00 | 1 Tackle, 2 Assists |
| LB | Cole Holcomb | Was | 10.0 | 11.00 | 154.00 | 6 Tackles, 4 Assists |
| LB | Foyesade Oluokun | Atl | 10.0 | 12.14 | 170.00 | 7 Tackles, 3 Assists |
| LB | Micah Parsons | Dal | 2.0 | 9.64 | 135.00 | 1 Assist, 1 PD |
| CB | Byron Murphy | Ari | 5.0 | 6.85 | 89.00 | 2 Tackles, 1 Fum Rcvy |
| S | Kevin Byard | Ten | 4.0 | 9.50 | 133.00 | 3 Tackles, 1 Assist |
| Position | 1st Backups | Proteam | TW | PPG | Total | Breakdown |
| QB | Taylor Heinicke | Was | 0(0.0) | 17.37 | 243.24 | Played, No Stats |
| RB | Mark Ingram | NO | 0(2.8) | 7.26 | 94.40 | 10 Rush, 8 Receiving, 2 Rec |
| WR | Tyler Boyd | Cin | 0(18.1) | 8.77 | 122.74 | 96 Receiving, 5 Rec, 1 TD |
| TE | Hunter Henry | NE | 0(22.7) | 8.69 | 121.60 | 77 Receiving, 6 Rec, 2 TD |
| HB (WR) | Julio Jones | Ten | 0(0.0) | 6.18 | 49.40 | Played, No Stats |
| DL | Maxx Crosby | LV | 0(4.0) | 4.86 | 68.00 | 4 Tackles |
| LB | Isaiah Simmons | Ari | 0(6.0) | 8.07 | 113.00 | 6 Tackles |
| S | Minkah Fitzpatrick | Pit | 0(17.0) | 9.38 | 122.00 | 12 Tackles, 2 Assists, 1 Fum Rcvy |
| Position | 2nd Backups | Proteam | TW | PPG | Total | Breakdown |
| RB | Samaje Perine | Cin | 0(5.3) | 5.09 | 66.20 | 30 Rush, 13 Receiving, 2 Rec |
| Offense = 93.58 Defense = 46 Total = 139.58 | ||||||
| Position | Bench | Proteam | TW | PPG | Total | Breakdown |
| RB | Damien Harris | NE | DNP | 11.86 | 142.30 | Did Not Play |
| RB | Kareem Hunt | Cle | DNP | 12.38 | 99.00 | Did Not Play |
| RB | Joshua Kelley | LAC | 0(1.1) | 1.61 | 12.90 | 21 Rush, 1 Fumb |
| RB | Phillip Lindsay | Mia | DNP | 3.13 | 34.40 | Did Not Play |
| RB | Darrel Williams | KC | 0(1.2) | 9.44 | 132.10 | 12 Rush |
| WR | Calvin Ridley | Atl | DNP | 11.12 | 55.60 | Did Not Play |
| WR | Jaylen Waddle | Mia | DNP | 12.09 | 157.20 | Did Not Play |
| Position | Injured Reserve | Proteam | TW | PPG | Total | Breakdown |
| WR | Michael Thomas | NO | DNP | 0.00 | 0 | Did Not Play |