| Pos. | Starters | Proteam | TW | PPG | Total | Breakdown |
| QB | Jared Goff | Det | 12.84 | 20.58 | 329.30 | 271 Pass, 1 TD, 2 Int |
| RB | Tony Pollard | Dal | 5.40 | 11.28 | 180.50 | 49 Rush, 1 Rec |
| RB | Javonte Williams | Den | 7.30 | 9.31 | 139.70 | 41 Rush, 17 Receiving, 3 Rec |
| WR | Justin Jefferson | Min | 8.40 | 15.47 | 139.20 | 59 Receiving, 5 Rec |
| WR | Puka Nacua | LAR | 16.20 | 14.62 | 233.90 | 19 Rush, 118 Receiving, 5 Rec |
| WR | Amon-Ra St. Brown | Det | 19.10 | 16.57 | 248.50 | 11 Rush, 90 Receiving, 6 Rec, 1 TD |
| TE | Sam LaPorta | Det | 11.90 | 11.56 | 184.90 | 84 Receiving, 7 Rec |
| HB | Amari Cooper | Cle | DNP | 0.00 | 0.00 | Did Not Play |
| PK | Jake Moody | SF | 9.00 | 8.06 | 129.00 | 2 FG(<40), 3 XP |
| DL | Jonathon Cooper | Den | 5.00 | 7.88 | 126.00 | 1 Tackle, 1.0 Sack |
| DL | Maxx Crosby | LV | 9.00 | 9.56 | 153.00 | 3 Tackles, 3 Assists, 1 FF |
| DL | Trey Hendrickson | Cin | 8.00 | 7.56 | 121.00 | 1 Tackle, 1.0 Sack, 1 FF |
| LB | Lavonte David | TB | 11.00 | 10.71 | 150.00 | 5 Tackles, 6 Assists |
| LB | Bobby Okereke | NYG | 16.00 | 11.19 | 179.00 | 2 Tackles, 8 Assists, 1.5 Sacks |
| LB | Fred Warner | SF | 6.00 | 11.75 | 188.00 | 2 Tackles, 4 Assists |
| CB | Ifeatu Melifonwu | Det | 9.00 | 3.93 | 59.00 | 3 Tackles, 1 Int, 1 PD |
| S | Jessie Bates | Atl | 11.00 | 11.50 | 184.00 | 9 Tackles, 2 Assists |
| Pos. | 1st Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Tua Tagovailoa | Mia | 0(18.88) | 20.23 | 323.74 | 237 Pass, 14 Rush, 2 TD, 2 Int |
| RB | Clyde Edwards-Helaire | KC | DNP | 0.00 | 0.00 | Did Not Play |
| WR | Jameson Williams | Det | 0(8.50) | 5.69 | 68.30 | 6 Rush, 69 Receiving, 2 Rec |
| TE | Tyler Conklin | NYJ | 0(7.00) | 5.63 | 90.00 | 45 Receiving, 5 Rec |
| WR | Jaxon Smith-Njigba | Sea | 7.70 | 7.21 | 115.40 | 12 Receiving, 1 Rec, 1 TD |
| PK | Harrison Butker | KC | 0(24.00) | 9.06 | 145.00 | 2 FG(<40), 3 FG(40-49), 1 FG(50-59), 1 XP |
| DL | Malcolm Koonce | LV | 0(3.00) | 4.88 | 78.00 | 1 Tackle, 2 Assists |
| LB | Nick Bolton | KC | 0(14.00) | 8.50 | 68.00 | 9 Tackles, 4 Assists, 1 PD |
| CB | L'Jarius Sneed | KC | 0(4.00) | 6.69 | 107.00 | 2 Tackles, 1 Assist, 1 PD |
| S | Jaquan Brisker | Chi | 0(5.00) | 8.71 | 122.00 | 4 Tackles, 1 Assist |
| Pos. | 2nd Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Brock Purdy | SF | 0(21.60) | 22.48 | 359.60 | 230 Pass, 4 Rush, 2 TD |
| RB | Joshua Kelley | LAC | 0(0.20) | 3.66 | 58.60 | 2 Rush |
| WR | Treylon Burks | Ten | 0(2.10) | 3.19 | 31.90 | 11 Receiving, 2 Rec |
| DL | Sam Hubbard | Cin | 0(8.00) | 6.00 | 84.00 | 3 Tackles, 2 Assists, 1 Fum Rcvy |
| LB | Jeremiah Owusu-Koramoah | Cle | 0(11.00) | 8.38 | 134.00 | 7 Tackles, 4 Assists |
| Offense = 97.84 Defense = 75 Total = 172.84 | ||||||
| Pos. | Bench | Proteam | TW | PPG | Total | Breakdown |
| RB | Zack Moss | Ind | DNP | 11.78 | 153.10 | Did Not Play |
| Pos. | Injured List | Proteam | TW | PPG | Total | Breakdown |
| QB | Hendon Hooker | Det | DNP | 0.00 | 0.00 | Did Not Play |