| Position | Starters | Proteam | TW | PPG | Total | Breakdown |
|---|---|---|---|---|---|---|
| QB | Justin Herbert | LAC | 21.68 | 26.52 | 424.34 | 237 Pass, 2 Rush, 2 TD |
| RB | Najee Harris | Pit | 28.1 | 16.01 | 256.20 | 188 Rush, 18 Receiving, 3 Rec, 1 TD |
| RB | Eli Mitchell | SF | 20.0 | 14.70 | 147.00 | 119 Rush, 11 Receiving, 2 Rec, 1 TD |
| WR | Justin Jefferson | Min | 8.8 | 16.11 | 257.80 | 58 Receiving, 6 Rec |
| WR | Cordarrelle Patterson | Atl | 6.2 | 13.79 | 206.90 | 28 Rush, 24 Receiving, 2 Rec |
| WR | Jaylen Waddle | Mia | 6.2 | 12.24 | 183.60 | 47 Receiving, 3 Rec |
| TE | Dawson Knox | Buf | 0.0 | 9.49 | 132.80 | Played, No Stats |
| HB (WR) | Odell Beckham | LAR | 12.4 | 8.02 | 104.30 | 39 Receiving, 5 Rec, 1 TD |
| PK | Greg Joseph | Min | 6.0 | 9.00 | 144.00 | 1 FG(50-59), 1 XP |
| DL | Marcus Davenport | NO | 5.0 | 7.60 | 76.00 | 2 Assists, 1 Fum Rcvy |
| DL | Dante Fowler | Atl | 3.0 | 4.77 | 62.00 | 2 Tackles, 1 Assist |
| DL | Javon Hargrave | Phi | 5.0 | 6.13 | 98.00 | 2 Tackles, 3 Assists |
| LB | David Long | Ten | 10.0 | 9.56 | 86.00 | 2 Tackles, 2 Assists, 1 Int, 1 PD |
| LB | Denzel Perryman | LV | 10.0 | 11.07 | 155.00 | 5 Tackles, 2 Assists, 1 FF |
| LB | Alex Singleton | Phi | 8.0 | 10.13 | 162.00 | 4 Tackles, 4 Assists |
| CB | Anthony Brown | Dal | 4.0 | 7.00 | 112.00 | 2 Tackles, 2 PD |
| S | Jeremy Chinn | Car | 8.0 | 8.00 | 128.00 | 4 Tackles, 1.0 Sack |
| Position | 1st Backups | Proteam | TW | PPG | Total | Breakdown |
| QB | Mac Jones | NE | 0(28.28) | 16.13 | 258.14 | 227 Pass, 12 Rush, 3 TD |
| HB (TE) | Pat Freiermuth | Pit | 0(4.7) | 7.63 | 114.40 | 22 Receiving, 5 Rec |
| DL | Austin Johnson | NYG | 0(5.0) | 5.38 | 86.00 | 4 Tackles, 1 Assist |
| LB | Tremaine Edmunds | Buf | 0(7.0) | 7.86 | 110.00 | 5 Tackles, 2 Assists |
| S | Jevon Holland | Mia | 0(8.0) | 7.00 | 105.00 | 7 Tackles, 1 PD |
| Position | 2nd Backups | Proteam | TW | PPG | Total | Breakdown |
| LB | Patrick Queen | Bal | 0(1.0) | 6.69 | 107.00 | 1 Tackle |
| Offense = 109.38 Defense = 53 Total = 162.38 | ||||||
| Position | Bench | Proteam | TW | PPG | Total | Breakdown |
| RB | Antonio Gibson | Was | DNP | 12.70 | 190.50 | Did Not Play |
| RB | Darrell Henderson | LAR | DNP | 12.41 | 148.90 | Did Not Play |
| RB | Justin Jackson | LAC | 0(7.6) | 5.71 | 74.20 | 41 Rush, 20 Receiving, 3 Rec |
| RB | Craig Reynolds | Det | 0(1.8) | 1.97 | 31.50 | 4 Rush, 9 Receiving, 1 Rec |
| RB | Jonathan Williams | Was | 0(2.1) | 0.95 | 14.20 | 4 Rush, 7 Receiving, 2 Rec |
| WR | Chris Godwin | TB | 0(0.0) | 13.03 | 195.40 | Played, No Stats |
| WR | Elijah Moore | NYJ | DNP | 10.61 | 116.70 | Did Not Play |
| RB | Derrick Gore | KC | 0(5.0) | 3.27 | 49.10 | 37 Rush, 8 Receiving, 1 Rec |
| LB | Azeez Al-Shaair | SF | DNP | 10.08 | 131.00 | Did Not Play |
| LB | Blake Martinez | NYG | DNP | 7.67 | 23.00 | Did Not Play |
| Position | Injured Reserve | Proteam | TW | PPG | Total | Breakdown |
| WR | Calvin Ridley | Atl | DNP | 11.12 | 55.60 | Did Not Play |