| Round | Overall | Player |
|---|---|---|
| 1 | 3rd | RB Reggie Bush NO |
| 2 | 22nd | RB Julius Jones Dal |
| 3 | 27th | QB Carson Palmer Cin |
| 4 | 46th | TE Tony Gonzalez KC |
| 5 | 51st | WR Andre Johnson Hou |
| 6 | 70th | WR Mark Clayton Bal |
| 7 | 75th | WR Lee Evans Buf |
| 8 | 94th | LB Cato June Ind |
| 9 | 99th | DL Robert Mathis Ind |
| 10 | 118th | WR Nate Burleson Sea |
| 11 | 123rd | WR Troy Williamson Min |
| 12 | 142nd | RB Michael Turner SD |
| 13 | 147th | QB David Carr Car |
| 14 | 166th | S Roy Williams Dal |
| 15 | 171st | RB Jerome Harrison Cle |
| 16 | 190th | WR Roddy White Atl |
| 17 | 195th | LB Demarcus Ware Dal |
| 18 | 214th | PK Josh Brown Sea |
| 19 | 219th | CB Antrel Rolle Ari |
| 20 | 238th | WR Mike Williams Det |
| 21 | 243rd | RB J.J. Arrington Ari |
| 22 | 262nd | TE Leonard Pope Ari |
| 23 | 267th | LB Manny Lawson SF |
| 24 | 286th | DL Robert Bernard Sea |
| 25 | 291st | DL Richard Seymour NE |
| 26 | 310th | LB Gary Brackett Ind |
| 27 | 315th | CB Tye Hill StL |
| 28 | 334th | S Ken Hamlin Dal |